{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:11:32Z","timestamp":1761491492652,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cLa Caixa\u201d Foundation","award":["ID100010434"],"award-info":[{"award-number":["ID100010434"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Accelerometers can estimate the intensity, frequency, and duration of physical activity in healthy adults. Although thresholds to distinguish varying levels of activity intensity using the Actigraph wGT3X-B have been established for the general population, their accuracy for Huntington\u2019s disease (HD) is unknown. We aimed to define and cross-validate accelerometer cut-points for different walking speeds in adults with mild to moderate HD. A cross-sectional, multicentre, case-control, observational study was conducted with a convenience sample of 13 symptomatic ambulatory HD participants. The accelerometer was placed around the right hip, and a heart monitor was fitted around the chest to monitor heart rate variability. Participants walked on a treadmill at three speeds with light, moderate and vigorous intensities. Correlation and receiver operation curve analyses were performed between the accelerometer magnitude vector with relative oxygen and heart rate. Optimal cut-points for walking speeds of 3.2 km\/h were \u22642852; 5.2 km\/h: &gt;2852 to \u22644117, and in increments until their maximum velocity: &gt;4117. Our results support the application of the disease-specific cut-points for quantifying physical activity in patients with mild to moderate HD and promoting healthy lifestyle interventions.<\/jats:p>","DOI":"10.3390\/ijerph192214834","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T02:29:32Z","timestamp":1668392972000},"page":"14834","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Accelerometer Cut-Points for Physical Activity Assessment in Adults with Mild to Moderate Huntington\u2019s Disease: A Cross-Sectional Multicentre Study"],"prefix":"10.3390","volume":"19","author":[{"given":"Luc\u00eda","family":"Sim\u00f3n-Vicente","sequence":"first","affiliation":[{"name":"Burgos University Hospital, 09006 Burgos, Spain"},{"name":"Faculty of Health Sciences, University of Burgos, 09001 Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica","family":"Rivadeneyra-Posadas","sequence":"additional","affiliation":[{"name":"Burgos University Hospital, 09006 Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6202-0328","authenticated-orcid":false,"given":"Mar\u00eda","family":"Soto-C\u00e9lix","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University Isabel I, 09003 Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3570-7159","authenticated-orcid":false,"given":"Javier","family":"Raya-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University Isabel I, 09003 Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4159-6475","authenticated-orcid":false,"given":"Daniel","family":"Castillo","sequence":"additional","affiliation":[{"name":"Valoraci\u00f3n del Rendimiento Deportivo, Actividad F\u00edsica y Salud y Lesiones Deportivas (REDAFLED), University of Valladolid, 42004 Soria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Calvo","sequence":"additional","affiliation":[{"name":"Burgos University Hospital, 09006 Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4365-3138","authenticated-orcid":false,"given":"Carla","family":"Collazo","sequence":"additional","affiliation":[{"name":"Burgos University Hospital, 09006 Burgos, Spain"},{"name":"Faculty of Health Sciences, University of Burgos, 09001 Burgos, Spain"},{"name":"Faculty of Health Sciences, University Isabel I, 09003 Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0893-7573","authenticated-orcid":false,"given":"Alejandro","family":"Rodr\u00edguez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"VALFIS Research Group, Institute of Biomedicine (IBIOMED), Faculty of Sciences of Physical Activity and Sports, Universidad de Leon, 24004 Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitoria S.","family":"Fahed","sequence":"additional","affiliation":[{"name":"Insight Centre for Data Analytics, University College Dublin, D04 V1W8 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natividad","family":"Mariscal","sequence":"additional","affiliation":[{"name":"Burgos University Hospital, 09006 Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2561-1003","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Garc\u00eda-Bustillo","sequence":"additional","affiliation":[{"name":"Burgos University Hospital, 09006 Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Aguado","sequence":"additional","affiliation":[{"name":"Burgos University Hospital, 09006 Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Cubo","sequence":"additional","affiliation":[{"name":"Burgos University Hospital, 09006 Burgos, Spain"},{"name":"Faculty of Health Sciences, University of Burgos, 09001 Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022, June 06). Global Recommendations on Physical Activity for Health, Available online: http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/44399\/9789241599979_eng.pdf;jsessionid=F720BE062F514924A03B872A30E82525?sequence=1."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7807856","DOI":"10.1155\/2020\/7807856","article-title":"Potential Benefits of Physical Activity in MCI and Dementia","volume":"2020","author":"Nuzum","year":"2020","journal-title":"Behav. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Do, K., Laing, B.T., Landry, T., Bunner, W., Mersaud, N., Matsubara, T., Li, P., Yuan, Y., Lu, Q., and Huang, H. (2018). The effects of exercise on hypothalamic neurodegeneration of Alzheimer\u2019s disease mouse model. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0190205"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4103\/aian.AIAN_169_18","article-title":"Role of Physical Activity in Parkinson\u2019s Disease","volume":"21","author":"Bhalsing","year":"2018","journal-title":"Ann. Indian Acad. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s004150050272","article-title":"Huntington\u2019s disease and other choreas","volume":"245","author":"Quinn","year":"1998","journal-title":"J. Neurol."},{"key":"ref_6","unstructured":"Perandones, C., Radrizzani, M., and Micheli, F. (2011). Enfermedad de Huntington. Movimientos Anormales Cl\u00ednica y Terap\u00e9utica, M\u00e9dica Panamericana."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1001\/archneur.1991.00530200036015","article-title":"Factors Associated with Slow Progression in Huntington\u2019s Disease","volume":"48","author":"Myers","year":"1991","journal-title":"Arch. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e01578","DOI":"10.1002\/brb3.1578","article-title":"The relationship between lifestyle and serum neurofilament light protein in Huntington\u2019s disease","volume":"10","author":"Cruickshank","year":"2020","journal-title":"Brain Behav."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/s41591-020-1012-3","article-title":"Wearable-device-measured physical activity and future health risk","volume":"26","author":"Strain","year":"2020","journal-title":"Nat. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Nero, H., Wall\u00e9n, M.B., Franz\u00e9n, E., St\u00e5hle, A., and Hagstromer, M. (2015). Accelerometer Cut Points for Physical Activity Assessment of Older Adults with Parkinson\u2019s Disease. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0135899"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jsams.2011.04.003","article-title":"Validation and comparison of ActiGraph activity monitors","volume":"14","author":"Sasaki","year":"2011","journal-title":"J. Sci. Med. Sport"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Duncan, M.J., Dobell, A., Noon, M., Clark, C.C.T., Roscoe, C.M.P., Faghy, M.A., Stodden, D., Sacko, R., Eyre, E.L.J., and Dobell, A. (2020). Calibration and Cross-Validation of Accelerometery for Estimating Movement Skills in Children Aged 8\u201312 Years. Sensors, 20.","DOI":"10.3390\/s20102776"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.gaitpost.2018.11.023","article-title":"Calibration of wrist-worn ActiWatch 2 and ActiGraph wGT3X for assessment of physical activity in young adults","volume":"68","author":"Lee","year":"2019","journal-title":"Gait Posture"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1080\/02701367.2000.10608878","article-title":"Assessment of Physical Activity with the Computer Science and Applications, Inc., Accelerometer: Laboratory versus Field Validation","volume":"71","author":"Nichols","year":"2000","journal-title":"Res. Q. Exerc. Sport"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.870110204","article-title":"Unified Huntington\u2019s disease rating scale: Reliability and consistency. Huntington Study Group","volume":"11","author":"Kieburtz","year":"1996","journal-title":"Mov. Disord."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1079\/PHN2005935","article-title":"The SUN cohort study (Seguimiento University of Navarra)","volume":"9","year":"2006","journal-title":"Public Health Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.genhosppsych.2007.11.005","article-title":"Behavioural problems in Huntington\u2019s disease using the Problem Behaviours Assessment","volume":"30","author":"Kingma","year":"2008","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3233\/JHD-190350","article-title":"Cognitive Screening Tests in Huntington Gene Mutation Carriers: Examining the Validity of the Mini-Mental State Examination and the Montreal Cognitive Assessment","volume":"9","author":"Larsen","year":"2020","journal-title":"J. Huntington\u2019s Dis."},{"key":"ref_19","first-page":"1259","article-title":"Defining accelerometer thresholds for activity intensities in adolescent girls","volume":"36","author":"Treuth","year":"2004","journal-title":"Med. Sci. Sport. Exerc."},{"key":"ref_20","unstructured":"World Health Organization (2022, May 01). Global Database on Body Mass Index [Internet]. Available online: http:\/\/www.assessmentpsychology.com\/icbmi.htm#:~:text=Global%20Database%20on%20Body%20Mass%20Index%20-%20World%20Health%20Organization&text=Body%20Mass%20Index%20(BMI)%20is%20(kg%2Fm2)."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","article-title":"The meaning and use of the area under a receiver operating characteristic (ROC) curve","volume":"143","author":"Hanley","year":"1982","journal-title":"Radiology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S501","DOI":"10.1249\/01.mss.0000185660.38335.de","article-title":"Principles of Design and Analyses for the Calibration of Accelerometry-Based Activity Monitors","volume":"37","author":"Welk","year":"2005","journal-title":"Med. Sci. Sport. Exerc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1249\/MSS.0b013e318285f03b","article-title":"Validity of ActiGraph Child-Specific Equations during Various Physical Activities","volume":"45","author":"Crouter","year":"2013","journal-title":"Med. Sci. Sport Exerc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1080\/02640414.2017.1293279","article-title":"Wrist-based cut-points for moderate- and vigorous-intensity physical activity for the Actical accelerometer in adults","volume":"36","author":"Diaz","year":"2018","journal-title":"J. Sport Sci."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Keadle, S.K., Shiroma, E.J., Freedson, P.S., and Lee, I.-M. (2014). Impact of accelerometer data processing decisions on the sample size, wear time and physical activity level of a large cohort study. BMC Public Health, 14.","DOI":"10.1186\/1471-2458-14-1210"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1055\/s-0033-1337945","article-title":"Actigraph GT3X: Validation and Determination of Physical Activity Intensity Cut Points","volume":"34","author":"Cardon","year":"2013","journal-title":"Int. J. Sport. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.gaitpost.2021.10.027","article-title":"Wrist-based accelerometer cut-points for quantifying moderate-to-vigorous intensity physical activity in Parkinson\u2019s disease","volume":"91","author":"Jeng","year":"2022","journal-title":"Gait Posture"},{"key":"ref_28","first-page":"13","article-title":"Actigraph GT3X+ cut points in coronary artery disease patients: A pilot study","volume":"8","author":"Mark","year":"2015","journal-title":"Health Fit. J. Can."},{"key":"ref_29","first-page":"125","article-title":"Objective measurement of sedentary time and physical activity in people with rheumatoid arthritis: Protocol for an accelerometer and activPALTM validation study","volume":"30","author":"Duda","year":"2019","journal-title":"Mediterr. J. Rheumatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.apmr.2009.03.020","article-title":"Calibration of Accelerometer Output for Ambulatory Adults With Multiple Sclerosis","volume":"90","author":"Motl","year":"2009","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1080\/10749357.2016.1183866","article-title":"Validating accelerometry as a measure of physical activity and energy expenditure in chronic stroke","volume":"24","author":"Serra","year":"2017","journal-title":"Top. Stroke Rehabil."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"S531","DOI":"10.1249\/01.mss.0000185657.86065.98","article-title":"Conducting Accelerometer-Based Activity Assessments in Field-Based Research","volume":"37","author":"Trost","year":"2005","journal-title":"Med. Sci. Sport Exerc."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/22\/14834\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:14:25Z","timestamp":1760145265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/22\/14834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,11]]},"references-count":32,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["ijerph192214834"],"URL":"https:\/\/doi.org\/10.3390\/ijerph192214834","relation":{},"ISSN":["1660-4601"],"issn-type":[{"type":"electronic","value":"1660-4601"}],"subject":[],"published":{"date-parts":[[2022,11,11]]}}}