{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T23:12:39Z","timestamp":1775776359937,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Ministry of Health and Welfare Clinical Trial Center, Taiwan","award":["MOHW109-TDU-B-212-114004"],"award-info":[{"award-number":["MOHW109-TDU-B-212-114004"]}]},{"name":"The Ministry of Health and Welfare Clinical Trial Center, Taiwan","award":["MOST 109-2321-B-039-002"],"award-info":[{"award-number":["MOST 109-2321-B-039-002"]}]},{"name":"The Ministry of Health and Welfare Clinical Trial Center, Taiwan","award":["DMR-110-222"],"award-info":[{"award-number":["DMR-110-222"]}]},{"name":"MOST Clinical Trial Consortium for Stroke","award":["MOHW109-TDU-B-212-114004"],"award-info":[{"award-number":["MOHW109-TDU-B-212-114004"]}]},{"name":"MOST Clinical Trial Consortium for Stroke","award":["MOST 109-2321-B-039-002"],"award-info":[{"award-number":["MOST 109-2321-B-039-002"]}]},{"name":"MOST Clinical Trial Consortium for Stroke","award":["DMR-110-222"],"award-info":[{"award-number":["DMR-110-222"]}]},{"name":"China Medical University Hospital","award":["MOHW109-TDU-B-212-114004"],"award-info":[{"award-number":["MOHW109-TDU-B-212-114004"]}]},{"name":"China Medical University Hospital","award":["MOST 109-2321-B-039-002"],"award-info":[{"award-number":["MOST 109-2321-B-039-002"]}]},{"name":"China Medical University Hospital","award":["DMR-110-222"],"award-info":[{"award-number":["DMR-110-222"]}]},{"name":"Tseng-Lien Lin Foundation, Taichung, Taiwan","award":["MOHW109-TDU-B-212-114004"],"award-info":[{"award-number":["MOHW109-TDU-B-212-114004"]}]},{"name":"Tseng-Lien Lin Foundation, Taichung, Taiwan","award":["MOST 109-2321-B-039-002"],"award-info":[{"award-number":["MOST 109-2321-B-039-002"]}]},{"name":"Tseng-Lien Lin Foundation, Taichung, Taiwan","award":["DMR-110-222"],"award-info":[{"award-number":["DMR-110-222"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>We conducted this study to investigate the long-term outcomes of sulfonylurea (SU) use in patients with chronic obstructive pulmonary disease (COPD) and type 2 diabetes (T2D). We used propensity-score matching to identify 6008 pairs of SU users and nonusers from Taiwan\u2019s National Health Insurance Research Database from 1 January 2000 to 31 December 2017. Cox proportional hazard models were used to compare the risks of mortality, cardiovascular events, non-invasive positive pressure ventilation, invasive mechanical ventilation, bacterial pneumonia, lung cancer, and hypoglycemia between SU users and nonusers. In the matched cohorts, the mean follow-up time for SU users and nonusers was 6.57 and 5.48 years, respectively. Compared with nonusers, SU users showed significantly lower risks of mortality [aHR 0.53(0.48\u20130.58)], cardiovascular events [aHR 0.88(0.81\u20130.96)], non-invasive positive pressure ventilation [aHR 0.74(0.6\u20130.92)], invasive mechanical ventilation [aHR 0.57(0.5\u20130.66)], and bacterial pneumonia [aHR 0.78(0.7\u20130.87)]. A longer cumulative duration of SU use was associated with a lower risk of these outcomes. This nationwide cohort study demonstrated that SU use was associated with significantly lower risks of cardiovascular events, ventilation use, bacterial pneumonia, and mortality in patients with COPD and T2D. SU may be a suitable option for diabetes management in these patients.<\/jats:p>","DOI":"10.3390\/ijerph192215013","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T02:27:34Z","timestamp":1668565654000},"page":"15013","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sulfonylurea Use in Patients with Type 2 Diabetes and COPD: A Nationwide Population-Based Cohort Study"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4677-2415","authenticated-orcid":false,"given":"Fu-Shun","family":"Yen","sequence":"first","affiliation":[{"name":"Dr. Yen\u2019s Clinic, No. 15, Shanying Road, Gueishan District, Taoyuan 33354, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1235-0679","authenticated-orcid":false,"given":"James Cheng-Chung","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Rd., South District, Taichung 40201, Taiwan"},{"name":"Department of Medicine, Chung Shan Medical University Hospital, No. 110, Sec. 1, Jianguo N. Rd., South District, Taichung 40201, Taiwan"},{"name":"Graduate Institute of Integrated Medicine, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng-Shun","family":"Yu","sequence":"additional","affiliation":[{"name":"Management Office for Health Data, China Medical University Hospital, 3F, No. 373-2, Jianxing Road, Taichung 40459, Taiwan"},{"name":"College of Medicine, China Medical University, No. 91, Xueshi Road, Taichung 40202, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5632-2733","authenticated-orcid":false,"given":"Chung Y.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4563-4341","authenticated-orcid":false,"given":"Chih-Cheng","family":"Hsu","sequence":"additional","affiliation":[{"name":"Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan"},{"name":"Department of Health Services Administration, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan"},{"name":"Department of Family Medicine, Min-Sheng General Hospital, 168 ChingKuo Road, Taoyuan 33044, Taiwan"},{"name":"National Center for Geriatrics and Welfare Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8209-9627","authenticated-orcid":false,"given":"Chii-Min","family":"Hwu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, Taipei 11221, Taiwan"},{"name":"Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Beitou District, Taipei 11217, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1016\/S0140-6736(22)00470-6","article-title":"Chronic obstructive pulmonary disease","volume":"399","author":"Christenson","year":"2022","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S2213-2600(21)00511-7","article-title":"Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: A systematic review and modelling analysis","volume":"10","author":"Adeloye","year":"2022","journal-title":"Lancet Respir. 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