{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T15:30:11Z","timestamp":1773588611863,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>(1) Aim: Ultrasound is the gold standard for assessing fetal growth disorders. The relationship between high sFlt-1\/PlGF scores and LBW (low birth weight) was described. In this study, we attempted to assess whether uric acid could be used as a secondary marker in estimating the pregnancy risk associated with LBW. (2) Material and methods: 665 pregnant women with a suspected or confirmed form of placental insufficiency were enrolled. In each of the patients, sFlt-1 and PlGF and uric acid levels were determined. Patients were divided into two groups according to birth weight below and above the third percentile for the given gestational age with the criteria of the neonatal definition of FGR (fetal growth restriction). (3) Results: A significant negative correlation between neonatal birth weight and the uric acid level across the entire study group was observed. We found a significant negative correlation between neonatal birth weight and the uric acid level with birth weights &lt; 3rd percentile. (4) Conclusions: There is a significant link between the uric acid concentration and LBW in the group with placental insufficiency. Uric acid can improve the prediction of LBW. An algorithm for LBW prognosis that makes use of biophysical (ultrasound) and biochemical (uric acid level, angiogenesis markers) parameters yields better results than using these parameters separately from each other.<\/jats:p>","DOI":"10.3390\/ijerph192215059","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T02:27:34Z","timestamp":1668565654000},"page":"15059","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Birth Weight &lt; 3rd Percentile Prediction Using Additional Biochemical Markers\u2014The Uric Acid Level and Angiogenesis Markers (sFlt-1, PlGF)\u2014An Exploratory Study"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-7774","authenticated-orcid":false,"given":"Magdalena","family":"Bednarek-J\u0119drzejek","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8279-5585","authenticated-orcid":false,"given":"Sylwia","family":"Dzidek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Tousty","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9847-6589","authenticated-orcid":false,"given":"Ewa","family":"Kwiatkowska","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneta","family":"Cymbaluk-P\u0142oska","sequence":"additional","affiliation":[{"name":"Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"G\u00f3ra","sequence":"additional","affiliation":[{"name":"Clinical Department of Gynecology and Obstetrics, John Paul 2nd Municipal Hospital, 35-241 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartosz","family":"Czuba","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical University of Silesia, 40-055 Ruda Slaska, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Torb\u00e9","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1504-3639","authenticated-orcid":false,"given":"Sebastian","family":"Kwiatkowski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2965094","DOI":"10.1155\/2019\/2965094","article-title":"Associated Factors with Low Birth Weight in Dire Dawa City, Eastern Ethiopia: A Cross-Sectional Study","volume":"2019","author":"Sema","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"ref_2","first-page":"1061","article-title":"Fetal growth restriction: Current knowledge","volume":"295","author":"Nardozza","year":"2017","journal-title":"ArchGynecol. Obstet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S855","DOI":"10.1016\/j.ajog.2017.12.004","article-title":"Evidence-based national guidelines for the management of suspected fetal growth restriction: Comparison, consensus, and controversy","volume":"218","author":"McCowan","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Lees, C., Visser, G.H.A., Hecher, K., Gandhi, R., and Marlow, N. (2018). Fetal Growth Restriction and Neonatal Outcomes. Placental-Fetal Growth Restriction, Cambridge University Press.","DOI":"10.1017\/9781316181898"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.patbio.2006.04.009","article-title":"\u00c9tude biochimique du sang f\u0153tal pr\u00e9lev\u00e9 par cordocent\u00e8se au cours de 35 grossesses compliqu\u00e9es de retard de croissance","volume":"55","author":"Bon","year":"2007","journal-title":"Pathol. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000343260","article-title":"Intrauterine growth restriction and the innate immune system in preterm infants of \u226432 weeks gestation","volume":"103","author":"Faust","year":"2013","journal-title":"Neonatology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"212","DOI":"10.2174\/1573396314666180712114531","article-title":"Neonatal and Long-Term Consequences of Fetal Growth Restriction","volume":"14","author":"Colella","year":"2018","journal-title":"Curr. Pediatr. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3109\/14767058.2012.715006","article-title":"Short-term and long-term sequelae in intrauterine growth retardation (IUGR)","volume":"26","author":"Longo","year":"2013","journal-title":"J. Matern. Neonatal. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/uog.20272","article-title":"ISUOG Practice Guidelines: Ultrasound assessment of fetal biometry and growth","volume":"53","author":"Salomon","year":"2019","journal-title":"Ultrasound. Obstet. Gynecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/uog.15884","article-title":"Consensus definition of fetal growth restriction: A Delphi procedure","volume":"48","author":"Gordijn","year":"2016","journal-title":"Ultrasound. Obstet. Gynecol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jpeds.2017.12.059","article-title":"Consensus Based Definition of Growth Restriction in the Newborn","volume":"196","author":"Beune","year":"2018","journal-title":"J. Pediatr."},{"key":"ref_12","unstructured":"National Collaborating Centre for Women\u2019s and Children\u2019s Health (UK) (2010). Hypertension in Pregnancy: The Management of Hypertensive Disorders During Pregnancy, RCOG Press."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1515\/jpm-2019-0019","article-title":"The sFlt-1\/PlGF ratio values within the <38, 38\u201385 and >85 brackets as compared to perinatal outcomes","volume":"47","author":"Kwiatkowski","year":"2019","journal-title":"J. Perinat. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.preghy.2018.08.448","article-title":"sFlt-1\/PlGF and Doppler ultrasound parameters in SGA pregnancies with confirmed neonatal birth weight below 10th percentile","volume":"14","author":"Kwiatkowski","year":"2018","journal-title":"Pregnancy Hypertens"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/ajo.12831","article-title":"Placental growth factor as an indicator of fetal growth restriction in late-onset small-for-gestational age pregnancies","volume":"59","author":"Anderson","year":"2019","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"1Akahori, Y., Masuyama, H., and Hiramatsu, Y. (2012). The Correlation of Maternal Uric Acid Concentration with Small-for-Gestational-Age Fetuses in Normotensive Pregnant Women. Gynecol. Obstet. Investig., 73, 162\u2013167.","DOI":"10.1159\/000332391"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/14767058.2018.1484093","article-title":"Maternal serum uric acid levels in pregnancy and fetal growth","volume":"33","author":"Zhou","year":"2020","journal-title":"J. Matern. Neonatal. Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Fenton, T.R., and Kim, J.H. (2013). A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants. BMC Pediatr., 13.","DOI":"10.1186\/1471-2431-13-59"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1111\/j.1471-0528.1981.tb02224.x","article-title":"\u201cLupus\u201d Anticoagulant And Inhibition of Prostacyclin Formation in Patients with Repeated Abortion, Intrauterine Growth Retardation and Intrauterine Death","volume":"88","author":"Carreras","year":"1981","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/S0022-3476(80)80620-2","article-title":"Decreased birth weight in infants of alcoholic women who abstained during pregnancy","volume":"96","author":"Little","year":"1980","journal-title":"J. Pediatr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0002-9378(15)33248-8","article-title":"Fetal growth retardation in cigarette-smoking mothers is not due to decreased maternal food intake","volume":"137","author":"Haworth","year":"1980","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0002-9378(76)90775-4","article-title":"Assessment of intrauterine growth retardation by diagnostic ultrasound","volume":"125","author":"Whetham","year":"1976","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1515\/jpme.1976.4.2.85","article-title":"Ultrasound and biochemical findings in intrauterine growth retardation","volume":"4","author":"Kunz","year":"1976","journal-title":"J. Perinat. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1471-0528.1982.tb03634.x","article-title":"Measurement of fundal height as a screening test for fetal growth retardation","volume":"89","author":"Rosenberg","year":"1982","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0002-9378(77)90464-1","article-title":"Prediction of intrauterine growth retardation by determination of total intrauterine volume","volume":"127","author":"Gohari","year":"1977","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/0002-9378(72)90565-0","article-title":"Placental insufficiency and the small-for-dates baby","volume":"113","author":"Scott","year":"1972","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1515\/jpme.1975.3.4.248","article-title":"An endocrine model for the diagnosis of intrauterine growth retardation as demonstrated by the determination of total estrogen and pregnandiol 24-h urinary excretion in 222 at risk pregnancies","volume":"3","author":"Wolfrum","year":"1975","journal-title":"J. Perinat. Med."},{"key":"ref_28","first-page":"517","article-title":"Detection of pregnancy-specific beta 1-glycoproteins (SP1) and pregnancy-associated plasma protein A (PAPP-A) in maternal serum. Diagnostic significance in intrauterine fetal retardation","volume":"106","author":"Briese","year":"1984","journal-title":"Zentralbl. Gynakol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1471-0528.1984.tb04740.x","article-title":"Placental protein measurements in complicated pregnancies. I. Intrauterine growth retardation","volume":"91","author":"Westergaard","year":"1984","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.3109\/14767058.2013.879703","article-title":"Eliminating first trimester markers: Will replacing PAPP-A and \u03b2hCG miss women at risk for small for gestational age?","volume":"27","author":"Dukhovny","year":"2014","journal-title":"J. Matern. Neonatal. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/uog.5165","article-title":"First-trimester biochemical markers of aneuploidy and the prediction of small-for-gestational age fetuses","volume":"31","author":"Spencer","year":"2008","journal-title":"Ultrasound. Obstet. Gynecol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1046\/j.0004-8666.2003.00126.x","article-title":"Association between first trimester maternal serum pregnancy associated plasma protein-A and adverse pregnancy outcome","volume":"43","author":"Kwik","year":"2003","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1055\/s-0038-1660777","article-title":"Uterine artery doppler in screening for preeclampsia and fetal growth restriction","volume":"40","author":"Pedroso","year":"2018","journal-title":"Rev. Bras. Ginecol. Obstet."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e16069","DOI":"10.1097\/MD.0000000000016069","article-title":"Better prediction for FGR (fetal growth restriction) with the sFlt-1\/PIGF ratio: A case-control study","volume":"98","author":"Visan","year":"2019","journal-title":"Medicine"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41591-020-0804-9","article-title":"A maternal serum metabolite ratio predicts fetal growth restriction at term","volume":"26","author":"Sovio","year":"2020","journal-title":"Nat. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S2352-4642(18)30129-9","article-title":"Screening for fetal growth restriction using ultrasound and the sFLT1\/PlGF ratio in nulliparous women: A prospective cohort study","volume":"2","author":"Gaccioli","year":"2018","journal-title":"Lancet Child Adolesc. Health"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1471-0528.1984.tb05895.x","article-title":"Changes in serum uric acid concentrations during normal pregnancy","volume":"91","author":"Lind","year":"1984","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/labmed\/lmaa088","article-title":"Trimester-Specific Reference Intervals of Serum Urea, Creatinine, and Uric Acid Among Healthy Pregnant Women in Zhengzhou, China","volume":"52","author":"Gao","year":"2020","journal-title":"Lab. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e15462","DOI":"10.1097\/MD.0000000000015462","article-title":"Predictive value of serum uric acid levels for adverse perinatal outcomes in preeclampsia","volume":"98","author":"Ryu","year":"2019","journal-title":"Medicine"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s13224-016-0933-8","article-title":"Estimation of Serum Uric Acid as an Indicator of Severity of Preeclampsia and Perinatal Outcome","volume":"67","author":"Nair","year":"2017","journal-title":"J. Obstet. Gynecol. India"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.preghy.2017.10.002","article-title":"Impact of maternal serum uric acid on perinatal outcome in women with hypertensive disorders of pregnancy: A prospective study","volume":"10","author":"Kumar","year":"2017","journal-title":"Pregnancy Hypertens."},{"key":"ref_42","first-page":"256","article-title":"PP026. Hyperuricemia in the prognosis of adverse perinatal outcomes","volume":"2","author":"Escudero","year":"2012","journal-title":"Pregnancy Hypertens Int. J. Women\u2019s Cardiovasc. Health"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0301-2115(97)00248-0","article-title":"Lone hyperuricemia during pregnancy: Maternal and fetal outcomes","volume":"77","author":"Merviel","year":"1998","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_44","first-page":"446","article-title":"The correlation between serum uric acid levels in the third trimester of pregnancy and adverse pregnancy outcomes","volume":"60","author":"Sun","year":"2021","journal-title":"Zhonghua Nei Ke Za Zhi"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/22\/15059\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:19:06Z","timestamp":1760145546000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/22\/15059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,16]]},"references-count":44,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["ijerph192215059"],"URL":"https:\/\/doi.org\/10.3390\/ijerph192215059","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,16]]}}}