{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:44:57Z","timestamp":1791855897170,"version":"4.3.4"},"reference-count":156,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UCM-SANTANDER","award":["PR26\/16-22B-1"],"award-info":[{"award-number":["PR26\/16-22B-1"]}]},{"name":"UCM-SANTANDER","award":["PR26\/16-22B-2"],"award-info":[{"award-number":["PR26\/16-22B-2"]}]},{"name":"UCM-SANTANDER","award":["PR26\/16-33B3"],"award-info":[{"award-number":["PR26\/16-33B3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Loneliness is considered a prognostic factor for poorer health status in the elderly. It is proposed to analyze the role of loneliness in health status in terms of various factors. A total of 1747 individuals from the pilot survey of the Aging in Spain Longitudinal Study (ELES-PS) were reviewed. ELES is a cross-sectional study for collecting health variables, food habits, socioeconomic data, and cognitive and functional capacities, which was carried out on a Spanish representative sample of noninstitutionalized persons of 50 years of age or older. Moreover, since telomere shortening is associated with cellular senescence, 35 telomere-related SNPs and cognitive impairments were analyzed. The results characterize the \u201csolos\u201d as males of 50\u201360 years, who were overweight and had lower levels of hemoglobin and neutrophils. There is also an association between five SNPs related to telomere length and BDNF. A group of people with loneliness and depression was identified with poorer health and cognitive status, poorer perception of their quality of life, poorer quality of sleep, and lower physical activity. Therefore, it follows that telomeres and BDNF play a role as intermediaries between loneliness and depression and their relationship with a worse state of health.<\/jats:p>","DOI":"10.3390\/ijerph192315456","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T08:25:28Z","timestamp":1669105528000},"page":"15456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Loneliness, Depression, and Genetics in the Elderly: Prognostic Factors of a Worse Health Condition?"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8808-4613","authenticated-orcid":false,"given":"Mar\u00eda Luisa","family":"Delgado-Losada","sequence":"first","affiliation":[{"name":"Experimental Psychology, Cognitive Processes and Speech Therapy Department, Faculty of Psychology, Complutense University of Madrid, 28223 Pozuelo de Alarc\u00f3n, Spain"},{"name":"Group of Neurosciences: Psychoneuroendocrinology, Neuroimaging and Molecular Genetics in Neuropsychiatric Diseases, Instituto de Investigaci\u00f3n Sanitaria San Carlos (IdISSC), Hospital Cl\u00ednico de Madrid, 28040 Madrid, Spain"},{"name":"UCM Research Group: VALORNUT-920030, Department of Nutrition and Food Science, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ram\u00f3n y Cajal s\/n, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Bouhaben","sequence":"additional","affiliation":[{"name":"Experimental Psychology, Cognitive Processes and Speech Therapy Department, Faculty of Psychology, Complutense University of Madrid, 28223 Pozuelo de Alarc\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-0589","authenticated-orcid":false,"given":"Eduardo","family":"Arroyo-Pardo","sequence":"additional","affiliation":[{"name":"Laboratory of Forensic and Population Genetics, Legal Medicine, Psychiatry and Pathology Department, Medicine School, Complutense University of Madrid, Plaza Ram\u00f3n y Cajal s\/n, 28040 Madrid, Spain"},{"name":"Group of Forensic Sciences: Forensic Genetics and Toxicology, Instituto de Investigaci\u00f3n Sanitaria San Carlos (IdISSC), Hospital Cl\u00ednico de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-9802","authenticated-orcid":false,"given":"Ar\u00e1nzazu","family":"Aparicio","sequence":"additional","affiliation":[{"name":"Group of Neurosciences: Psychoneuroendocrinology, Neuroimaging and Molecular Genetics in Neuropsychiatric Diseases, Instituto de Investigaci\u00f3n Sanitaria San Carlos (IdISSC), Hospital Cl\u00ednico de Madrid, 28040 Madrid, Spain"},{"name":"UCM Research Group: VALORNUT-920030, Department of Nutrition and Food Science, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ram\u00f3n y Cajal s\/n, 28040 Madrid, Spain"},{"name":"Department of Nutrition and Food Science, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ram\u00f3n y Cajal s\/n, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"L\u00f3pez-Parra","sequence":"additional","affiliation":[{"name":"Laboratory of Forensic and Population Genetics, Legal Medicine, Psychiatry and Pathology Department, Medicine School, Complutense University of Madrid, Plaza Ram\u00f3n y Cajal s\/n, 28040 Madrid, Spain"},{"name":"Group of Forensic Sciences: Forensic Genetics and Toxicology, Instituto de Investigaci\u00f3n Sanitaria San Carlos (IdISSC), Hospital Cl\u00ednico de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Rotenberg, K.J., and Hymel, S. (1999). Childhood and adolescent loneliness: An introduction. Loneliness in Childhood and Adolescence, Cambridge University Press.","DOI":"10.1017\/CBO9780511551888"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1080\/13607863.2020.1830945","article-title":"The effects of loneliness and social isolation on all-cause, injury, cancer, and CVD mortality in a cohort of middle-aged Finnish men. A prospective study","volume":"25","author":"Kraav","year":"2021","journal-title":"Aging Ment. Health"},{"key":"ref_3","first-page":"24","article-title":"The stability and change of loneliness across the life span: A meta-analysis of longitudinal studies","volume":"24","author":"Mund","year":"2020","journal-title":"J. Pers. Soc. Psychol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ercole, V., and Parr, J. (2020). Problems of loneliness and its impact on health and well-being. Good Health and Well-Being. Encyclopedia of the UN Sustainable Development Goals, Springer.","DOI":"10.1007\/978-3-319-69627-0_126-1"},{"key":"ref_5","unstructured":"Peplau, E.L.A., and Perlman, D. (1982). Perspectives on loneliness. Loneliness: A Sourcebook of Current Theory, Research and Therapy, Wiley."},{"key":"ref_6","unstructured":"Weiss, R. (1973). Loneliness: The Experience of Emotional and Social Isolation, MIT Press."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/spc3.12087","article-title":"Social relationships and health: The toxic effects of perceived social isolation","volume":"8","author":"Cacioppo","year":"2014","journal-title":"Soc. Pers. Psychol. Compass."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Perlman, D., and Vangelisti, A. (2006). Loneliness and social isolation. The Cambridge Handbook of Personal Relationships, Cambridge University Press.","DOI":"10.1017\/CBO9780511606632"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1159\/000441651","article-title":"Loneliness and healthin older adults: A mini-review and synthesis","volume":"62","author":"Ong","year":"2016","journal-title":"Gerontology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/13607863.2021.1875191","article-title":"Correlates of emotional and social loneliness among community dwelling older adults in Rotterdam, the Netherlands","volume":"26","author":"Wolfers","year":"2022","journal-title":"Aging Ment. Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1136\/heartjnl-2015-309242","article-title":"Loneliness and social isolation as risk factors for CVD: Implications for evidence-based patient care and scientific inquiry","volume":"102","author":"Smith","year":"2016","journal-title":"Heart"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.socscimed.2016.01.020","article-title":"Do stress, health behavior, and sleep mediate the association between loneliness and adverse health conditions among older people?","volume":"152","author":"Christiansen","year":"2016","journal-title":"Soc. Sci. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1080\/10410231003773334","article-title":"Functions of loneliness, social support, health behaviors, and stress in association with poor health","volume":"25","author":"Segrin","year":"2010","journal-title":"Health Commun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1136\/heartjnl-2020-316614","article-title":"Longitudinal associations between loneliness, social isolation and cardiovascular events","volume":"106","author":"Bu","year":"2020","journal-title":"Heart"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/abm\/kaaa044","article-title":"Loneliness, social isolation, and chronic disease outcomes","volume":"55","author":"Christiansen","year":"2021","journal-title":"Ann. Behav. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/00006842-200205000-00005","article-title":"Loneliness and health: Potential mechanisms","volume":"64","author":"Cacioppo","year":"2002","journal-title":"Psychosom. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1037\/0882-7974.21.1.152","article-title":"Loneliness is a unique predictor of age-related differences in systolic blood pressure","volume":"21","author":"Hawkley","year":"2006","journal-title":"Psychol. Aging"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/13548500500266607","article-title":"A comparison of health behaviours in lonely and non-lonely populations","volume":"11","author":"Lauder","year":"2006","journal-title":"Psychol. Health Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/psyg.12375","article-title":"Obesity and loneliness. Findings from a longitudinal population-based study in the second half of life in Germany","volume":"19","author":"Hajek","year":"2019","journal-title":"Psychogeriatrics"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0306-4530(03)00086-6","article-title":"Loneliness and neuroendocrine, cardiovascular, and inflammatory stress responses in middle-aged men and women","volume":"29","author":"Steptoe","year":"2004","journal-title":"Psychoneuroendocrinology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00006842-198401000-00003","article-title":"Psychosocial modifiers of immunocompetence in medical students","volume":"46","author":"Garner","year":"1984","journal-title":"Psychosom. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1037\/0278-6133.24.4.348","article-title":"\u201cLoneliness, social network size, and immune response to influenza vaccination in college freshman\u201d: Correction to Pressman et al","volume":"24","author":"Pressman","year":"2005","journal-title":"Health Psychol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"R189","DOI":"10.1186\/gb-2007-8-9-r189","article-title":"Social regulation of gene expression in human leukocytes","volume":"8","author":"Cole","year":"2007","journal-title":"Genome Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1073\/pnas.1014218108","article-title":"Transcript origin analysis identifies antigen-presenting cells as primary targets of socially regulated gene expression in leukocytes","volume":"108","author":"Cole","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.bbi.2008.02.006","article-title":"Social regulation of leukocyte homeostasis: The role of glucocorticoid sensitivity","volume":"22","author":"Cole","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/1745691614568352","article-title":"Loneliness and social isolation as risk factors for mortality: A meta-analytic review","volume":"10","author":"Smith","year":"2015","journal-title":"Perspect. Psychol. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.socscimed.2011.11.028","article-title":"Loneliness, health, and mortality in old age: A national longitudinal study","volume":"74","author":"Luo","year":"2012","journal-title":"Soc. Sci. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF02686768","article-title":"Factor analysis of the revised UCLA Loneliness Scale","volume":"9","author":"McWhirter","year":"1990","journal-title":"Curr. Psychol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1037\/0882-7974.21.1.140","article-title":"Loneliness as a specific risk factor for depressive symptoms: Cross-sectional and longitudinal analyses","volume":"21","author":"Cacioppo","year":"2006","journal-title":"Psychol. Aging"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1136\/jnnp-2012-302755","article-title":"Feelings of loneliness, but not social isolation, predict dementia onset: Results from the Amsterdam Study of the Elderly (AMSTEL)","volume":"85","author":"Holwerda","year":"2014","journal-title":"J. Neurol. Neurosurg Psychiatry"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1037\/0882-7974.17.1.116","article-title":"Age differences and similarities in the correlates of depressive symptoms","volume":"17","author":"Ahrens","year":"2002","journal-title":"Psychol. Aging"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/gps.4495","article-title":"Loneliness, depression and cognitive function in older U.S. adults","volume":"32","author":"Donovan","year":"2017","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1037\/dev0000719","article-title":"Loneliness and social anxiety across childhood and adolescence: Multilevel meta-analyses of cross-sectional and longitudinal associations","volume":"55","author":"Maes","year":"2019","journal-title":"Dev. Psychol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1037\/a0037618","article-title":"Toward a neurology of loneliness","volume":"140","author":"Cacioppo","year":"2014","journal-title":"Psychol. Bull."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0962-1849(99)80008-0","article-title":"Lonely hearts: Psychological perspectives on loneliness","volume":"8","author":"Ernst","year":"1999","journal-title":"Appl. Prev. Psychol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Boss, L., Branson, S., Cron, S., and Kang, D.H. (2016). Biobehavioral examination of religious coping, psychosocial factors, and executive function in homebound older adults. Religions, 7.","DOI":"10.3390\/rel7050042"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0167-4943(00)00070-4","article-title":"Social and emotional loneliness among non-demented and demented elderly people","volume":"31","author":"Ericsson","year":"2000","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/gerona\/59.3.M268","article-title":"Predictors of cognitive decline and mortality of aged people over a 10-year period","volume":"59A","author":"Tilvis","year":"2004","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1001\/archpsyc.64.2.234","article-title":"Loneliness and risk of Alzheimer disease","volume":"64","author":"Wilson","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1017\/S0033291711001772","article-title":"Increased risk of mortality associated with social isolation in older men: Only when feeling lonely? Results from the Amsterdam Study of the Elderly (AMSTEL)","volume":"42","author":"Holwerda","year":"2012","journal-title":"Psychol. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/13607863.2011.628977","article-title":"Loneliness and cognition in older people: The Dublin Healthy Ageing study","volume":"16","author":"Chin","year":"2012","journal-title":"Aging Ment. Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1027\/1614-0001.28.3.103","article-title":"Social support and successful aging: Investigating the relationships between lifetime cognitive change and life satisfaction","volume":"28","author":"Gow","year":"2007","journal-title":"J. Individ. Differ."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1159\/000351265","article-title":"Which social network or support factors are associated with Loneliness and cognitive function 553 cognitive abilities in old age?","volume":"59","author":"Gow","year":"2013","journal-title":"Gerontology"},{"key":"ref_44","first-page":"27","article-title":"Cognitive performance of Canadian seniors","volume":"22","author":"Gilmour","year":"2011","journal-title":"Health Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/PSY.0b013e31827f09cd","article-title":"Social isolation and loneliness: Relationships with cognitive function during 4 years of follow-up in the English longitudinal study of ageing","volume":"75","author":"Shankar","year":"2013","journal-title":"Psychosom. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1017\/S1041610214002749","article-title":"Loneliness and cognitive function in the older adult: A systematic review","volume":"27","author":"Boss","year":"2015","journal-title":"Int. Psychogeriatr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/geronj\/36.3.342","article-title":"Loneliness in the Swedish aged","volume":"36","author":"Berg","year":"1981","journal-title":"J. Gerontol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2190\/AG.78.3.b","article-title":"Who are lonely? Loneliness in different age groups (18\u201381 years old), using two measures of loneliness","volume":"78","author":"Nicolaisen","year":"2014","journal-title":"Int. J. Aging Hum. Dev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s00127-016-1279-3","article-title":"\u201cWhere are all the lonely people?\u201d A population-based study of high-risk groups across the life span","volume":"51","author":"Lasgaard","year":"2016","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"ref_50","first-page":"432","article-title":"Unwanted loneliness, health and social inequalities throughout the life cycle","volume":"35","year":"2020","journal-title":"Gac. Sanit."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1037\/dev0000117","article-title":"Age differences in loneliness from late adolescence to oldest old age","volume":"52","author":"Luhmann","year":"2016","journal-title":"Dev. Psychol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1375\/twin.10.2.267","article-title":"Longitudinal genetic analysis for loneliness in Dutch twins","volume":"10","author":"Boomsma","year":"2007","journal-title":"Twin Res. Hum. Genet."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/npp.2016.197","article-title":"Genome-Wide Association study of loneliness demonstrates a role for common variation","volume":"42","author":"Gao","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1038\/s41467-018-04930-1","article-title":"Elucidating the genetic basis of social interaction and isolation","volume":"9","author":"Day","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/1745691614564878","article-title":"The genetics of loneliness: Linking evolutionary theory to genoma-wide genetics, epigenetics, and social science","volume":"10","author":"Goossens","year":"2015","journal-title":"Perspect. Psychol. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/j.1469-7610.2011.02424.x","article-title":"The dopamine D2 receptor gene, perceived parental support, and adolescent loneliness: Longitudinal evidence for gene-environment interactions","volume":"52","author":"Goossens","year":"2011","journal-title":"J. Child Psychol. Psychaitry."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/YPG.0b013e328363f631","article-title":"Oxytocin receptor gene (OXTR) in relation to loneliness in adolescence: Interactions with sex, parental support, and DRD2 and 5-HTTLPR genotypes","volume":"23","author":"Verhagen","year":"2013","journal-title":"Psychiatr. Genet."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nsmb.3184","article-title":"Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects","volume":"23","author":"Shukla","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.leukres.2015.08.018","article-title":"Mutational analysis of telomere complex genes in Indian population with acquired aplastic anemia","volume":"39","author":"Singh","year":"2015","journal-title":"Leuk Res."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Hasanau, T., Pisarev, E., Kisil, O., Nonoguchi, N., Le Calvez-Kelm, F., and Zvereva, M. (2022). Detection of TERT Promoter Mutations as a Prognostic Biomarker in Gliomas: Methodology, Prospects, and Advances. Biomedicines, 10.","DOI":"10.3390\/biomedicines10030728"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/pcmr.12500","article-title":"High TERT promoter mutation frequency in non-acral cutaneous metastatic melanoma","volume":"29","author":"Ekedahl","year":"2016","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Sun, J., Zhang, J., Lu, J., Gao, J., Ren, X., Teng, L., Duan, H., Lin, Y., Li, X., and Zhang, B. (2016). BRAF V600E and TERT Promoter Mutations in Papillary Thyroid Carcinoma in Chinese Patients. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0153319"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1089\/gtmb.2015.0339","article-title":"Association between human telomerase reverse transcriptase gene variations and risk of developing breast cancer","volume":"20","author":"Oztas","year":"2016","journal-title":"Genet. Test Mol. Biomark."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1038\/ng.3423","article-title":"Poly(A)-specific ribonuclease (PARN) mediates 3\u2019-end maturation of the telomerase RNA component","volume":"47","author":"Moon","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1016\/j.jacc.2016.03.530","article-title":"Short telomere load, telomere length, and subclinical aterosclerosis: The PESA study","volume":"67","author":"Fuster","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/PSY.0b013e31828233bf","article-title":"Low social support is associated with shorter leukocyte telomere length in late life: Multi-ethnic study of atherosclerosis","volume":"75","author":"Carroll","year":"2013","journal-title":"Psychosom. Med."},{"key":"ref_67","unstructured":"Te\u00f3filo Rodr\u00edguez, J., Gonz\u00e1lez Cabezas, A.N., D\u00edaz Veiga, P., and Rodr\u00edguez Rodr\u00edguez, V. (2011). Estudio Longitudinal Envejecer en Espa\u00f1a, El Proyecto ELES."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"34","DOI":"10.5231\/psy.writ.2013.1611","article-title":"Funcionamiento cognitivo en personas mayores e influencia de variables socioeducativas: Resultados del Estudio ELES","volume":"6","author":"Facal","year":"2013","journal-title":"Escr. Psicol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.gaceta.2012.11.008","article-title":"An\u00e1lisis del sesgo de selecci\u00f3n en el piloto de un estudio longitudinal sobre envejecimiento en Espa\u00f1a","volume":"27","author":"Laso","year":"2013","journal-title":"Gac. Sanit."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Rodriguez-Laso, A., Abellan, A., Sancho, M., Pujol, R., Montorio, I., and Diaz-Veiga, P. (2014). Perceived economic situation, but not education level, is associated with disability prevalence in the Spanish elderly: Observational study. BMC Geriatr., 14.","DOI":"10.1186\/1471-2318-14-60"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1249\/00005768-199305000-00016","article-title":"A survey for assessing physicalactivity among older adults","volume":"25","author":"Dipietro","year":"1993","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/014662168500900307","article-title":"The development of a Rasch-type loneliness scale","volume":"9","author":"Kamphuis","year":"1985","journal-title":"Appl. Psychol. Meas."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1006600825693","article-title":"Living arrangements of older adults in the Netherlands and Italy: Coresidence values and behaviour and their consequences for loneliness","volume":"14","year":"1999","journal-title":"J. Cross Cult. Gerontol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D Scale: A self-report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl. Psychol. Meas."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0749-3797(18)30622-6","article-title":"Screening for depression in well older adults: Evaluation of a short form of the CES-D (Center for Epidemiologic Studies Depression Scale)","volume":"10","author":"Andresen","year":"1994","journal-title":"Am. J. Prev. Med."},{"key":"ref_77","unstructured":"Rey, A. (1964). L\u2019examen Clinique en Psychologie, Presses Universitaires de France."},{"key":"ref_78","unstructured":"Kaplan, E., Goodglass, H., and Weintraub, S. (2001). Boston Naming Test, Lippincott Williams and Wilkins. [2nd ed.]."},{"key":"ref_79","unstructured":"Banks, E.J., Breeze, E., Lessof, C., and Nazroo, J. (2006). Cognitive function. Retirement, Health and Relationships of the Older Population in England. The 2004 English Longitudinal Study of Ageing (Wave 2), The Institute for Fiscal Studies."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Tong, H.Y., Borobia, A.M., Quintana-D\u00edaz, M., Fabra, S., Gonz\u00e1lez-Vi\u00f1olis, M., Fern\u00e1ndez-Capit\u00e1n, C., Rodriguez-D\u00e1vila, M.A., Lorenzo, A., L\u00f3pez-Parra, A.M., and Ruiz-Gim\u00e9nez, N. (2021). Acenocoumarol pharmacogenetic dosing algorithm versus usual care in patients with venous thromboembolism: A Randomised Clinical Trial. J. Clin. Med., 10.","DOI":"10.3390\/jcm10132949"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1093\/bioinformatics\/btl268","article-title":"SNPStats: A web tool for the analysis of association studies","volume":"22","author":"Sole","year":"2006","journal-title":"Bioinformatics"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.recesp.2019.08.006","article-title":"Una puntuaci\u00f3n de riesgo gen\u00e9tico predice recurrencias en pacientes j\u00f3venes con infarto agudo de miocardio","volume":"73","author":"Alonso","year":"2020","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1053\/ajem.2003.50002","article-title":"Predicting adverse outcomes in a diagnosis-based protocol system for rapid sequence intubation","volume":"21","author":"Marvez","year":"2003","journal-title":"Am. J. Emerg. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/00006199-200609000-00003","article-title":"A meta-analytic study of predictors for loneliness during adolescence","volume":"55","author":"Mahon","year":"2006","journal-title":"Nurs. Res."},{"key":"ref_85","unstructured":"Birren, J.E., and Schaie, K.W. (2001). Social relations: An examination of social networks, social support, and sense of control. Handbook of the Psychology of Aging, Academic Press."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10433-009-0110-3","article-title":"Older adult loneliness: Myths and realities","volume":"6","author":"Dykstra","year":"2009","journal-title":"Eur. J. Ageing."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1353\/cja.2004.0023","article-title":"Old Age and Loneliness: Cross-sectional and Longitudinal Analyses in the Tampere Longitudinal Study on Aging","volume":"23","year":"2004","journal-title":"Can. J. Aging"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/ageing\/28.5.491","article-title":"Changes in and factors related to loneliness in older men. The Zutphen Elderly Study","volume":"28","author":"Tijhuis","year":"1999","journal-title":"Age Ageing"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1017\/S0144686X1000139X","article-title":"Age and loneliness in 25 European nations","volume":"31","author":"Yang","year":"2011","journal-title":"Ageing Soc."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1257\/app.5.2.86","article-title":"Health, Height, Height Shrinkage, and SES at Older Ages: Evidence from China","volume":"5","author":"Huang","year":"2013","journal-title":"Am. Econ. J. Appl. Econ."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jocd.2015.02.004","article-title":"Relationship Between Vertebral Fracture Burden, Height Loss, and Pulmonary Function in Postmenopausal Women with Osteoporosis","volume":"18","author":"Krege","year":"2015","journal-title":"J. Clin. Densitom."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/00006416-200409000-00007","article-title":"Height change and bone mineral density: Revisited","volume":"23","author":"Thornton","year":"2004","journal-title":"Orthop. Nurs."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"100863","DOI":"10.1016\/j.ehb.2020.100863","article-title":"Heigh shrinkage, health and mortality among older adults: Evidence from Indonesia","volume":"37","author":"Jain","year":"2020","journal-title":"Econ. Hum. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.regg.2010.06.003","article-title":"Anemia in the elderly","volume":"45","author":"Urrutia","year":"2010","journal-title":"Rev. Esp. Geriatr. Gerontol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1046\/j.1532-5415.2002.50313.x","article-title":"Looking at the relationship between hemoglobin concentration and prevalent mobility difficulty in older women. Should the criteria currently used to define anemia in older people be reevaluated?","volume":"50","author":"Chaves","year":"2002","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.critrevonc.2005.09.003","article-title":"Anemia in the elderly: Clinical findings and impact on health","volume":"58","author":"Balducci","year":"2006","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.amjmed.2005.08.027","article-title":"Impact of anemia on mortality, cognition, and function in community-dwelling elderly","volume":"119","author":"Denny","year":"2006","journal-title":"Am. J. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.blre.2005.12.002","article-title":"Anemia in the elderly: Current understanding and emerging concepts","volume":"20","author":"Eisenstaedt","year":"2006","journal-title":"Blood Rev."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1111\/j.1532-5415.2006.00863.x","article-title":"Association between mild anemia and executive function impairment in communitydwelling older women: The Women\u2019s Health and Aging Study II","volume":"54","author":"Chaves","year":"2006","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1532-5415.1975.tb00927.x","article-title":"A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients","volume":"23","author":"Pfeiffer","year":"1975","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/gerona\/glp163","article-title":"Red cell distribution width and mortality in older adults: A meta-analysis","volume":"65","author":"Patel","year":"2010","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/MAJ.0000000000000334","article-title":"Value of red cell distribution width for assessing disease activity in Crohn\u2019s disease","volume":"349","author":"Hu","year":"2015","journal-title":"Am. J. Med. Sci."},{"key":"ref_103","first-page":"319","article-title":"Anemia in the frail, elderly patient","volume":"11","year":"2016","journal-title":"Clin. Interv. Aging"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/cei.12836","article-title":"Intracellular signalling pathways: Targets to reverse immunosenescence","volume":"187","author":"Fulop","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1111\/j.1532-5415.2008.02018.x","article-title":"Neutrophils of centenarians show function levels similar to those of young adults","volume":"56","author":"Puerto","year":"2008","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.18632\/aging.101116","article-title":"Immune function parameters as markers of biological age and predictors of longevity","volume":"8","author":"Vida","year":"2016","journal-title":"Aging"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"649328","DOI":"10.3389\/fcell.2021.649328","article-title":"miR-376a Provokes Rectum Adenocarcinoma Via CTC1 Depletion-Induced Telomere Dysfunction","volume":"9","author":"Liu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10654-019-00563-w","article-title":"Observational and genetic studies of short telomeres and Alzheimer\u2019s disease in 67,000 and 152,000 individuals: A Mendelian randomization study","volume":"35","author":"Rasmussen","year":"2020","journal-title":"Eur. J. Epidemiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.3389\/fpsyg.2017.01224","article-title":"Loneliness in Relation to Depression: The Moderating Influence of a Polymorphism of the Brain Derived Neurotrophic Factor Gene on Self-efficacy and Coping Strategies","volume":"8","author":"Bedard","year":"2017","journal-title":"Front. Psychol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pscychresns.2016.04.014","article-title":"White matter integrity in major depressive disorder: Implications of childhood trauma, 5-HTTLPR and BDNF polymorphisms","volume":"253","author":"Tatham","year":"2016","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"157.e11","DOI":"10.1016\/j.neurobiolaging.2017.11.013","article-title":"Faster progression from MCI to probable AD for carriers of a single-nucleotide polymorphism associated with type 2 diabetes","volume":"64","author":"Girard","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s10522-015-9551-6","article-title":"Population-specific association of genes for telomere-associated proteins with longevity in an Italian population","volume":"16","author":"Crocco","year":"2015","journal-title":"Biogerontology"},{"key":"ref_113","first-page":"310","article-title":"Genome wide association and linkage analyses identified three loci\u20144q25, 17q23.2, and 10q11.21\u2014Associated with variation in leukocyte telomere length: The Long Life Family Study","volume":"4","author":"Lee","year":"2013","journal-title":"Front. Genet."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/abm\/kay064","article-title":"Loneliness and Telomere Length: Immune and Parasympathetic Function in Associations With Accelerated Aging","volume":"53","author":"Wilson","year":"2019","journal-title":"Ann. Behav. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/13607863.2011.629092","article-title":"Risk factors and mediating pathways of loneliness and social support in community-dwelling older adults","volume":"16","author":"Schnittger","year":"2012","journal-title":"Aging Ment. Health"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1590\/0102-311X00173212","article-title":"Factors associated with low life life satisfaction in community-dwelling elderly: FIBRA Study","volume":"29","author":"Pinto","year":"2013","journal-title":"Cad. Saude Publica"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.archger.2011.03.013","article-title":"What factors affect life satisfaction (LS) among the oldest-old?","volume":"54","author":"Enkvist","year":"2012","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1017\/S0033291700028932","article-title":"Cognitive function in depression: Its relationship to the presence and severity of intellectual decline","volume":"24","author":"Brown","year":"1994","journal-title":"Psychol. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1017\/S1355617797006310","article-title":"A quantitative review of cognitive deficits in depression and Alzheimer-type dementia","volume":"3","author":"Christensen","year":"1997","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"100","DOI":"10.12659\/MSM.891086","article-title":"Association of depression and loneliness with specific cognitive performance in non-demented elderly males","volume":"21","author":"Tzang","year":"2015","journal-title":"Med. Sci. Monit."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/geronb\/gbw037","article-title":"Loneliness and cognitive function in older adults: Findings from the Chinese longitudinal healthy longevity survey","volume":"72","author":"Zhong","year":"2017","journal-title":"J. Gerontol. B Psychol. Sci. Soc. Sci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/0146167207310454","article-title":"Mental exercising through simple socializing: Social interaction promotes general cognitive functioning","volume":"34","author":"Ybarra","year":"2008","journal-title":"Pers. Soc. Psychol. Bull."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1136\/jech-2016-208131","article-title":"Social capital interventions targeting older people and their impact on health: A systematic review","volume":"71","author":"Nyqvist","year":"2017","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.18632\/aging.203993","article-title":"Association between sleep parameters and longitudinal shortening of telomere length","volume":"14","author":"Jin","year":"2022","journal-title":"Aging"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1515\/revneuro-2021-0070","article-title":"Telomeres: The role of shortening and senescence in major depressive disorders and its therapeutic implications","volume":"33","author":"Schroder","year":"2022","journal-title":"Rev. Neurosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00127-020-01889-7","article-title":"Understanding loneliness in the twenty-first century: An update on correlates, risk factors, and potential solutions","volume":"55","author":"Lim","year":"2020","journal-title":"Soc. Psychiatr. Epidemiol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Sha, S., Pan, Y., and Chen, L. (2022). Associations between loneliness and frailty among older adults: Evidence from the China Health and Retirement Longitudinal Study. BMC Geriatr., 22.","DOI":"10.1186\/s12877-022-03044-0"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"104918","DOI":"10.1016\/j.psyneuen.2020.104918","article-title":"Metabolic dysregulation in older adults with depression and loneliness: The ATHLOS study","volume":"123","author":"Lara","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1136\/heartjnl-2017-312663","article-title":"Social isolatio4n and loneliness as risk factors for myocardial infarction, stroke and mortality: UK Biobank cohort study of 479 054 men and women","volume":"104","author":"Hakulinen","year":"2018","journal-title":"Heart"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/gerona\/glt147","article-title":"Loneliness, health, and longevity","volume":"69","author":"Stessman","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1073\/pnas.1219686110","article-title":"Social isolation, loneliness, and all-cause mortality in older men and women","volume":"110","author":"Steptoe","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1037\/a0017216","article-title":"Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago Health, Aging, and Social Relations Study","volume":"25","author":"Cacioppo","year":"2010","journal-title":"Psychol Aging"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1080\/13607863.2013.856863","article-title":"Correlates of social and emotional loneliness in older people: Evidence from an English community study","volume":"18","author":"Dahlberg","year":"2014","journal-title":"Aging Ment. Health"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.archger.2003.10.004","article-title":"Depressive symptoms in late life: A 10-year follow-up","volume":"38","author":"Heikkinen","year":"2004","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_135","first-page":"1213","article-title":"Loneliness and the health of older people","volume":"23","author":"Lawlor","year":"2008","journal-title":"Int. J. Geriatr. Psychiatry J. Psychiatry Late Life Allied Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e12472","DOI":"10.1111\/gbb.12472","article-title":"Predicting loneliness with polygenic scores of social, psychological and psychiatric traits","volume":"17","author":"Abdellaoui","year":"2018","journal-title":"Genes Brain Behav."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders (DSM-5VR), American Psychiatric Pub.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"e2255","DOI":"10.1002\/brb3.2255","article-title":"Telomere shortening in late-life depression: A potential marker of depression severity","volume":"11","author":"Xavier","year":"2021","journal-title":"Brain Behav."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1192\/bjp.bp.115.178798","article-title":"Telomere length and depression: Prospective cohort study and Mendelian randomisation study in 67 306 individuals","volume":"210","author":"Rode","year":"2017","journal-title":"Br. J. Psychiatry"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1126\/science.273.5276.749","article-title":"Why stress is bad for your brain","volume":"273","author":"Sapolsky","year":"1996","journal-title":"Science"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0006-8993(00)02950-4","article-title":"The neurobiology of stress: From serendipity to clinical relevance","volume":"886","author":"McEwen","year":"2000","journal-title":"Brain Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1385\/NMM:5:1:011","article-title":"Role of neurotrophic factors in the etiology and treatment of mood disorders","volume":"5","author":"Duman","year":"2004","journal-title":"Neuromol. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/mp.2013.105","article-title":"Serum BDNF concentrations as peripheral manifestations of depression: Evidence from a systematic review and meta-analyses on 179 associations (N = 9484)","volume":"19","author":"Molendijk","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fpsyt.2020.00038","article-title":"Association Between BDNF Gene Variant Rs6265 and the Severity of Depression in Antidepressant Treatment-Free Depressed Patients","volume":"11","author":"Losenkov","year":"2020","journal-title":"Front. Psychiatry"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"343","DOI":"10.9758\/cpn.2019.17.3.343","article-title":"Telomere Biology in Mood Disorders: An Updated, Comprehensive Review of the Literature","volume":"17","author":"Muneer","year":"2019","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Pousa, P.A., Souza, R.M., Melo, P.H.M., Correa, B.H.M., Mendon\u00e7a, T.S.C., Sim\u00f5es-E-Silva, A.C., and Miranda, D.M. (2021). Telomere Shortening and Psychiatric Disorders: A Systematic Review. Cells, 10.","DOI":"10.3390\/cells10061423"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jad.2018.08.025","article-title":"Low brain-derived neurotrophic factor levels in post-mortem brains of older adults with depression and dementia in a large clinicopathological sample","volume":"241","author":"Nunes","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.tics.2009.06.005","article-title":"Perceived social isolation and cognition","volume":"13","author":"Cacioppo","year":"2009","journal-title":"Trends Cogn. Sci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2015.06.036","article-title":"Loneliness is associated with poor prognosis in late-life depression: Longitudinal analysis of the Netherlands study of depression in older persons","volume":"185","author":"Holvast","year":"2015","journal-title":"J. Affect. Disord."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jad.2018.04.026","article-title":"Development and external validation of a prediction rule for an unfavorable course of late-life depression: A multicenter cohort study","volume":"235","author":"Maarsingh","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"809733","DOI":"10.3389\/fnbeh.2022.809733","article-title":"Loneliness and Health Indicators in Middle-Aged and Older Females and Males","volume":"16","author":"Hidalgo","year":"2022","journal-title":"Front. Behav. Neurosci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/mp.2014.119","article-title":"Telomere length and cortisol reactivity in children of depressed mothers","volume":"20","author":"Gotlib","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.psyneuen.2017.11.008","article-title":"Infant HPA axis as a potential mechanism linking maternal mental health and infant telomere length","volume":"88","author":"Nelson","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.2105\/AJPH.2007.121137","article-title":"Prevalence of chronic diseases and multimorbidity among the elderly population in Sweden","volume":"98","author":"Marengoni","year":"2008","journal-title":"Am. J. Public Health"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41398-020-01142-4","article-title":"Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms","volume":"11","author":"Bahrami","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1017\/S1041610209991426","article-title":"Situational versus chronic loneliness as risk factors for all-cause mortality","volume":"22","author":"Ayalon","year":"2010","journal-title":"Int. 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