{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:54:27Z","timestamp":1772754867042,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T00:00:00Z","timestamp":1669420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"HCCOMVIDA","award":["Chamada 01\/2020 (CPq N 02.25)"],"award-info":[{"award-number":["Chamada 01\/2020 (CPq N 02.25)"]}]},{"name":"HCCOMVIDA","award":["734548"],"award-info":[{"award-number":["734548"]}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Programme under ZIKAlliance","award":["Chamada 01\/2020 (CPq N 02.25)"],"award-info":[{"award-number":["Chamada 01\/2020 (CPq N 02.25)"]}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Programme under ZIKAlliance","award":["734548"],"award-info":[{"award-number":["734548"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Studies reported post-COVID-19 fatigue in the general population, but not among pregnant women. Our objectives were to determine prevalence, duration, and risk factors of post-viral fatigue among pregnant women with SARS-CoV-2. This study involved 588 pregnant women with SARS-CoV-2 during pregnancy or delivery in Brazil. Three groups were investigated: G1 (n = 259, symptomatic infection during pregnancy); G2 (n = 131, positive serology at delivery); G3 (n = 198, negative serology at delivery). We applied questionnaires investigating fatigue at determined timepoints after infection for G1, and after delivery for all groups; fatigue prevalence was then determined. Cox regression was used to estimate hazard ratio (HR) and 95% CI of the risk of remaining with fatigue in G1. Overall fatigue prevalence in G1 at six weeks, three months and six months were 40.6%, 33.6%, and 27.8%, respectively. Cumulative risk of remaining with fatigue increased over time, with HR of 1.69 (95% CI: 0.89\u20133.20) and 2.43 (95% CI: 1.49\u20133.95) for women with moderate and severe symptoms, respectively. Multivariate analysis showed cough and myalgia as independent risk factors in G1. Fatigue prevalence was significantly higher in G1 compared to G2 and G3. Post-viral fatigue prevalence is higher in women infected during pregnancy; fatigue\u2019s risk and duration increased with the severity of infection.<\/jats:p>","DOI":"10.3390\/ijerph192315735","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T04:58:50Z","timestamp":1669784330000},"page":"15735","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Post-Viral Fatigue Following SARS-CoV-2 Infection during Pregnancy: A Longitudinal Comparative Study"],"prefix":"10.3390","volume":"19","author":[{"given":"Ana Maria da Silva Sousa","family":"Oliveira","sequence":"first","affiliation":[{"name":"Disciplina de Obstetr\u00edcia, Departamento de Obstetr\u00edcia e Ginecologia da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7193-4917","authenticated-orcid":false,"given":"Mariana Azevedo","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Disciplina de Obstetr\u00edcia, Departamento de Obstetr\u00edcia e Ginecologia da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Nacul","sequence":"additional","affiliation":[{"name":"Complex Chronic Diseases Program\u2014BC Women\u2019s Hospital and Health Centre, Vancouver, BC V6H 3N1, Canada"},{"name":"Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8178-2136","authenticated-orcid":false,"given":"F\u00e1bio Roberto","family":"Cabar","sequence":"additional","affiliation":[{"name":"Disciplina de Obstetr\u00edcia, Departamento de Obstetr\u00edcia e Ginecologia da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Wictky","family":"Fabri","sequence":"additional","affiliation":[{"name":"Disciplina de Obstetr\u00edcia, Departamento de Obstetr\u00edcia e Ginecologia da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8120-2920","authenticated-orcid":false,"given":"Stela Verzinhasse","family":"Peres","sequence":"additional","affiliation":[{"name":"Disciplina de Obstetr\u00edcia, Departamento de Obstetr\u00edcia e Ginecologia da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana Assuncao","family":"Zaccara","sequence":"additional","affiliation":[{"name":"Disciplina de Obstetr\u00edcia, Departamento de Obstetr\u00edcia e Ginecologia da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shennae","family":"O\u2019Boyle","sequence":"additional","affiliation":[{"name":"UK Health Security Agency, London SW1P 3JR, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6707-7876","authenticated-orcid":false,"given":"Neal","family":"Alexander","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilton Hideto","family":"Takiuti","sequence":"additional","affiliation":[{"name":"Disciplina de Obstetr\u00edcia, Departamento de Obstetr\u00edcia e Ginecologia da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5730-947X","authenticated-orcid":false,"given":"Philippe","family":"Mayaud","sequence":"additional","affiliation":[{"name":"Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de Lourdes","family":"Brizot","sequence":"additional","affiliation":[{"name":"Disciplina de Obstetr\u00edcia, Departamento de Obstetr\u00edcia e Ginecologia da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9981-8069","authenticated-orcid":false,"given":"Rossana Pulcineli Vieira","family":"Francisco","sequence":"additional","affiliation":[{"name":"Disciplina de Obstetr\u00edcia, Departamento de Obstetr\u00edcia e Ginecologia da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Divis\u00e3o de Obstetr\u00edcia e Ginecolog\u00eda, Hospital Universit\u00e1rio da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,26]]},"reference":[{"key":"ref_1","first-page":"2000094","article-title":"First cases of coronavirus disease 2019 (COVID-19) in France: Surveillance, investigations and control measures, January 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