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Triptolide, an extract from the Chinese herb Tripterygium wilfordii Hook F, has been used for treating autoimmune and inflammatory diseases in clinical practice. However, whether triptolide attenuates acute muscle damage is still unclear. Here, we examined the effect of triptolide on carrageenan-induced DOMS in rats. Rats were injected with 3% of carrageenan into their muscles to induce acute left gastrocnemius muscular damage, and triptolide treatment attenuated carrageenan-induced acute muscular damage without affecting hepatic function. Triptolide can significantly decrease lipid hydroperoxide and nitric oxide (NO) levels, proinflammatory cytokine production, and the activation of nuclear factor (NF)-\u0138B, as well as increase a reduced form of glutathione levels in carrageenan-treated rat muscles. At the enzyme levels, triptolide reduced the inducible nitric oxide synthase (iNOS) expression and muscular myeloperoxidase (MPO) activity in carrageenan-treated DOMS rats. In conclusion, we show that triptolide can attenuate muscular damage by inhibiting muscular oxidative stress and inflammation in a carrageenan-induced rat DOMS model.<\/jats:p>","DOI":"10.3390\/ijerph192416685","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T05:42:00Z","timestamp":1670823720000},"page":"16685","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Triptolide Attenuates Muscular Inflammation and Oxidative Stress in a Delayed-Onset Muscle Soreness Animal Model"],"prefix":"10.3390","volume":"19","author":[{"given":"Che-Chia","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Chuan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, E-Da Dachang Hospital, Kaohsiung 82445, Taiwan"},{"name":"School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung 82445, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Yen","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Hsien","family":"Kwan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 60002, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Yie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5534-8993","authenticated-orcid":false,"given":"Po-Ting","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan"},{"name":"Medical Device Innovation Center, National Cheng Kung University, Tainan 70428, Taiwan"},{"name":"Department of Orthopaedics, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan"},{"name":"Department of Biomedical Engineering, National Cheng Kung University, Tainan 70428, Taiwan"},{"name":"Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I-Ming","family":"Jou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, E-Da Hospital, Kaohsiung 82445, Taiwan"},{"name":"School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan"},{"name":"GEG Orthopedic Clinic, Tainan 74543, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"ref_1","first-page":"16","article-title":"Herbs and natural supplements in the prevention and treatment of delayed-onset muscle soreness","volume":"7","author":"Meamarbashi","year":"2017","journal-title":"Avicenna J. 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