{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:52:22Z","timestamp":1762080742969,"version":"build-2065373602"},"reference-count":56,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Introduction: The COVID-19 pandemic stressed the necessity of a new resilience of the human population and health system. The \u201cWeCare Generation\u201d program is a new proposal of territorial intervention, with a new paradigm, on the diseases of the human body and mind. Background: In recent decades, the independent strands of investigation on brain plasticity and early trauma consequences have demonstrated that traumatic experiences in the period from pregnancy to the age of 3 years have an enormous impact on an individual\u2019s future development, and both physical and mental health. Research shows that adverse child experiences (ACEs) are associated with a strong risk of conditions such as: harmful alcohol use, smoking, illicit drug use, high body-mass index, depression, anxiety, interpersonal violence, cancer, type 2 diabetes, cardiovascular diseases, stroke respiratory diseases and, as a consequence, to a high financial cost in Italy and also across Europe (1\u20139% GDP) and the USA (total annual costs estimated to be USD 581 billion in Europe and USD 748 billion in North America). All this suggests that an early intervention on that traumatized-slice of population leads to multiplied savings. Methods: A multi-center, randomized, controlled trial was designed. The parents of the future neonatal population (from pregnancy to delivery) with trauma will be enrolled, and randomized to treatment, or control arm. The article describes in detail how the primary outpoint (cost to the national health system), and some secondary outpoints, will be collected. Discussion: An overall rate of return on investment (ROI) statistically significant 13.0% per annum with an associated benefit\/cost ratio (BCR) of 6.3 is expected as the primary outcome of the \u201cWeCare Generation\u201d program. Our proposed model predicts a new medical paradigm aiming to empower new generations, with a strong return on economy and health.<\/jats:p>","DOI":"10.3390\/ijerph192416741","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T01:52:34Z","timestamp":1670982754000},"page":"16741","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["1000 Days: The \u201cWeCare Generation\u201d Program\u2014The Ultimate Model for Improving Human Mental Health and Economics: The Study Protocol"],"prefix":"10.3390","volume":"19","author":[{"given":"Orlando","family":"Uccellini","sequence":"first","affiliation":[{"name":"Department of Mental Health, ASST Brianza, 20871 Vimercate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Benlodi","sequence":"additional","affiliation":[{"name":"Clinical Psychology Unit Carlo Poma Hospital, ASST Mantova, 46100 Mantua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9602-8208","authenticated-orcid":false,"given":"Emanuele","family":"Caroppo","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Local Health Authority Roma 2, 00159 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3162-9237","authenticated-orcid":false,"given":"Loredana","family":"Cena","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9442-0254","authenticated-orcid":false,"given":"Gianluca","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Psychology and Cognitive Science, University of Trento, 38122 Trent, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Fernandez","sequence":"additional","affiliation":[{"name":"EMDR Italia Association, 20814 Varedo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Ghazanfar","sequence":"additional","affiliation":[{"name":"Maternal and Child Department, ASST Brianza, 20871 Vimercate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Imbasciati","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Longo","sequence":"additional","affiliation":[{"name":"Cergas Center for Research on Health and Social Care Management, SDA Bocconi University, 20136 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3007-8162","authenticated-orcid":false,"given":"Marianna","family":"Mazza","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Neuroscience and Orthopedics, Institute of Psychiatry and Psychology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Universita\u2019 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Marano","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Neuroscience and Orthopedics, Institute of Psychiatry and Psychology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Universita\u2019 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3832-2860","authenticated-orcid":false,"given":"Renata","family":"Nacinovich","sequence":"additional","affiliation":[{"name":"Child and Adolescent Neuropsichiatry, ASST Monza, NeuroMI\u2014Milan Center for Neuroscience, University of Milano Bicocca, 20126 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6465-2716","authenticated-orcid":false,"given":"Antonio","family":"Pignatto","sequence":"additional","affiliation":[{"name":"Department of Psychology, IUSTO\u2014Salesian University Institute Torino Rebaudengo, 10155 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Rolnick","sequence":"additional","affiliation":[{"name":"Department of Economics, Humphrey School of Public Affairs, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Trivelli","sequence":"additional","affiliation":[{"name":"General and Economic Direction, ASST Brianza, 20871 Vimercate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Spada","sequence":"additional","affiliation":[{"name":"Magistica, 23875 Lecco, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4045-6128","authenticated-orcid":false,"given":"Cinzia","family":"Vanzini","sequence":"additional","affiliation":[{"name":"Training Sector Management, ASST Brianza, 20871 Vimercate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12888-022-03790-w","article-title":"Prevalence of post-traumatic stress disorder symptoms among patients with mental disorder during the COVID-19 pandemic","volume":"22","author":"Tang","year":"2022","journal-title":"BMC Psychiatry"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Brivio, E., Oliveri, S., Guiddi, P., and Pravettoni, G. 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