{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:52:02Z","timestamp":1760244722849,"version":"build-2065373602"},"reference-count":59,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"La Trobe University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Vitamin D deficiency and obesity are global health problems that are associated with increased asthma risk in children. The purpose of this study was to investigate whether BMI modifies pulmonary function across vitamin D tertiles in pediatric asthma patients of the mild asthma phenotype. This cross-sectional study conducted from November 2016\u2013September 2017 compared lung function variability as assessed by spirometry and nitric oxide in exhaled breath (FeNO) among 35 normal-weight and 26 overweight\/obese Greek schoolchildren (5\u201312 years old) with mild asthma. Serum 25 (OH)D levels \u2265 30 ng\/mL were defined as \u2018sufficient\u2019, 20\u201330 ng\/mL \u2018insufficient\u2019, and &lt;20 ng\/mL \u2018deficient\u2019. Stratification by BMI category, linear regression showed positive associations between D, % FVC (\u03b2 = 0.49, 95%CI: 0.05, 0.94), and % FEV1 (\u03b2 = 0.48, 95%CI: \u22120.01, 0.95) in the normal-weight only, adjusted for age, sex, regular exercise, and medication. FEV1 was 10% higher in the normal-weight D-sufficient group compared to those D-deficient (\u03b2 = 10.43, 95%CI: 0.54, 20.32). No associations were observed for the overweight\/obese group or FeNO. In conclusion, BMI modified associations of vitamin D on airway mechanics in children of the mild asthma phenotype. Serum 25 (OH)D concentrations \u2265 30 ng\/mL were associated with higher ventilation in central airways of normal-weight asthmatic children.<\/jats:p>","DOI":"10.3390\/ijerph192416768","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T02:54:21Z","timestamp":1670986461000},"page":"16768","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does BMI Modify the Association between Vitamin D and Pulmonary Function in Children of the Mild Asthma Phenotype?"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-7141","authenticated-orcid":false,"given":"Maria Michelle","family":"Papamichael","sequence":"first","affiliation":[{"name":"Human Services & Sport, School of Allied Health, La Trobe University, Melbourne 3086, Australia"},{"name":"European Institute of Molecular Medicine, 00198 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Itsiopoulos","sequence":"additional","affiliation":[{"name":"Human Services & Sport, School of Allied Health, La Trobe University, Melbourne 3086, Australia"},{"name":"School of Health & Biomedical Sciences, RMIT University, Melbourne 3083, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charis","family":"Katsardis","sequence":"additional","affiliation":[{"name":"Medical School, National & Kapodistrian University of Athens, 157 72 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitris","family":"Tsoukalas","sequence":"additional","affiliation":[{"name":"European Institute of Molecular Medicine, 00198 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bircan","family":"Erbas","sequence":"additional","affiliation":[{"name":"School of Psychology & Public Health, La Trobe University, Melbourne 3086, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5334\/aogh.2412","article-title":"The Global Impact of Asthma in Adult Populations","volume":"85","author":"Enilari","year":"2019","journal-title":"Ann. 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