{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:05:14Z","timestamp":1789239914358,"version":"build-2803163510"},"reference-count":119,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T00:00:00Z","timestamp":1671321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institute of Heart Diseases, Wroclaw Medical University","award":["SUBZ.A460.22.055"],"award-info":[{"award-number":["SUBZ.A460.22.055"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Among different pathomechanisms involved in the development of heart failure, adverse metabolic myocardial remodeling closely related to ineffective energy production, constitutes the fundamental feature of the disease and translates into further progression of both cardiac dysfunction and maladaptations occurring within other organs. Being the component of key enzymatic machineries, iron plays a vital role in energy generation and utilization, hence the interest in whether, by correcting systemic and\/or cellular deficiency of this micronutrient, we can influence the energetic efficiency of tissues, including the heart. In this review we summarize current knowledge on disturbed energy metabolism in failing hearts as well as we analyze experimental evidence linking iron deficiency with deranged myocardial energetics.<\/jats:p>","DOI":"10.3390\/ijerph192417000","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T05:55:43Z","timestamp":1671429343000},"page":"17000","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Iron Deficiency and Deranged Myocardial Energetics in Heart Failure"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5426-5432","authenticated-orcid":false,"given":"Micha\u0142","family":"Tkaczyszyn","sequence":"first","affiliation":[{"name":"Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland"},{"name":"Institute of Heart Diseases, University Hospital, 50-566 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof Micha\u0142","family":"G\u00f3rniak","sequence":"additional","affiliation":[{"name":"Institute of Heart Diseases, University Hospital, 50-566 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weronika Hanna","family":"Lis","sequence":"additional","affiliation":[{"name":"Institute of Heart Diseases, University Hospital, 50-566 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[{"name":"Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland"},{"name":"Institute of Heart Diseases, University Hospital, 50-566 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa Anita","family":"Jankowska","sequence":"additional","affiliation":[{"name":"Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland"},{"name":"Institute of Heart Diseases, University Hospital, 50-566 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/ejhf.1858","article-title":"Epidemiology of heart failure","volume":"22","author":"Groenewegen","year":"2020","journal-title":"Eur. 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