{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:33:48Z","timestamp":1793082828962,"version":"4.5.0"},"reference-count":31,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: The NR3C2 gene encodes the mineralocorticoid receptor, which is present on cardiomyocytes. Prior studies reported an association between the presence of NR3C2 single-nucleotide polymorphisms (SNPs) and an increased cortisol production during a stress response such as acute myocardial infarction (AMI), which may lead to adverse cardiac remodeling. Objective: To study the impact of the NR3C2 rs2070950, rs4635799 and rs5522 gene polymorphisms on left ventricular (LV) remodeling, rhythm and conduction disorders in AMI patients. Methods: A cohort of 301 AMI patients who underwent revascularization was included. SNPs of the NR3C2 gene (rs2070950, rs4635799 and rs5522) were evaluated. A total of 127 AMI patients underwent transthoracic echocardiography follow-up after 72 h and 6 months. Results: The rs2070950 GG genotype and rs4635799 TT genotype were most common in patients who had LV end-diastolic volume increase &lt; 20% and the same or increased LV ejection fraction, indicating a possible protective effect of these SNPs. The rs5522 TT genotype was associated with a higher frequency of arrhythmias, while the presence of at least one rs5522 C allele was associated with a lower risk of arrhythmias. Conclusion: SNPs of the NR3C2 gene appear to correlate with better ventricular remodeling and a reduced rate of arrhythmias post-AMI, possibly by limiting the deleterious effects of cortisol on cardiomyocytes.<\/jats:p>","DOI":"10.3390\/ijerph20010012","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T04:45:53Z","timestamp":1671511553000},"page":"12","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impact of Mineralocorticoid Receptor Gene NR3C2 on the Prediction of Functional Classification of Left Ventricular Remodeling and Arrhythmia after Acute Myocardial Infarction"],"prefix":"10.3390","volume":"20","author":[{"given":"Rima","family":"Braukyliene","sequence":"first","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania"},{"name":"Kaunas Region Lithuanian Society of Cardiology, Eiveniu Str. 2, 50009 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5567-2221","authenticated-orcid":false,"given":"Ali","family":"Aldujeli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania"},{"name":"Kaunas Region Lithuanian Society of Cardiology, Eiveniu Str. 2, 50009 Kaunas, Lithuania"},{"name":"Laboratory of Molecular Cardiology, Lithuanian University of Health Sciences, Sukileliu 15, 50162 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7093-420X","authenticated-orcid":false,"given":"Ayman","family":"Haq","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute, 800 E 28th St Heart Hospital Minneapolis, Minneapolis, MN 55407, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurynas","family":"Maciulevicius","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darija","family":"Jankauskaite","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martynas","family":"Jurenas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania"},{"name":"Kaunas Region Lithuanian Society of Cardiology, Eiveniu Str. 2, 50009 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramunas","family":"Unikas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania"},{"name":"Kaunas Region Lithuanian Society of Cardiology, Eiveniu Str. 2, 50009 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vytautas","family":"Zabiela","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania"},{"name":"Kaunas Region Lithuanian Society of Cardiology, Eiveniu Str. 2, 50009 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaiva","family":"Lesauskaite","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cardiology, Lithuanian University of Health Sciences, Sukileliu 15, 50162 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3365-2297","authenticated-orcid":false,"given":"Sandrita","family":"Simonyte","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cardiology, Lithuanian University of Health Sciences, Sukileliu 15, 50162 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Zaliaduonyt\u0117","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania"},{"name":"Kaunas Region Lithuanian Society of Cardiology, Eiveniu Str. 2, 50009 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/PSY.0000000000000429","article-title":"Perceived Stress After Acute Myocardial Infarction: A Comparison Between Young and Middle-Aged Women Versus Men","volume":"79","author":"Xu","year":"2017","journal-title":"Psychosom. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.15420\/ecr.2017:19:3","article-title":"Neuroendocrine System Regulatory Mechanisms: Acute Coronary Syndrome and Stress Hyperglycaemia","volume":"13","author":"Swieszkowski","year":"2018","journal-title":"Eur. Cardiol. 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