{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T23:39:12Z","timestamp":1782430752384,"version":"3.54.5"},"reference-count":48,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Investigaci\u00f3n Sanitaria de Santiago","award":["P2522\/2022"],"award-info":[{"award-number":["P2522\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Red cell distribution width (RDW) could be of interest by its potential use in the assessment of celiac disorder (CD). The main objective of this study was to evaluate the case positive rate of CD and the utility of red cell distribution width (RDW) in the CD diagnosis. This prospective study included 9.066 middle adult (\u226545 years old) and elderly patients (\u226560 years old) from 2012 to 2021. CD diagnosis was performed by CD antibody tests (serology and Human Leucocyte Antigen genotype (HLA)) and biopsy. Gastrointestinal and extra-intestinal manifestations as well as hematological and biochemical parameters were analyzed. CD diagnoses were confirmed in 101 patients (median (IQR) age = 62 (52.3\u201373); 68.32% women) by serologic tests (100%) and intestinal biopsy (88.12%), showing mainly marked or complete atrophy (76.24%, MARSH 3a\u2013c). Anemia was the most commonly presenting extra-intestinal manifestation (28.57%). Among 8975 individuals without CD, 168 age and sex matched were included. By comparison of CD and no CD individuals, we observed that high &gt;14.3% RDW was exhibited by 58.40% and 35.2% individuals with CD and without CD, respectively. Furthermore, high RDW is associated with CD and grade III atrophy. We suggest that RDW could be used as a CD screening criterion.<\/jats:p>","DOI":"10.3390\/ijerph20010066","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T06:11:24Z","timestamp":1671603084000},"page":"66","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Red Cell Distribution Width as a Predictive Factor of Celiac Disease in Middle and Late Adulthood and Its Potential Utility as Celiac Disease Screening Criterion"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6329-7409","authenticated-orcid":false,"given":"Julia Mar\u00eda","family":"Cabo del Riego","sequence":"first","affiliation":[{"name":"Clinical Analysis Laboratory, Department of Immunology, Lucus Augusti University Hospital, 27003 Lugo, Spain"},{"name":"Doctoral Programme in Medicine Clinical Research, International PhD School of the University of Santiago de Compostela (EDIUS), 15782 Santiago de Compostela, Spain"},{"name":"SNLLaboratory, School of Medicine and Dentistry, University of Santiago de Compostela, 15782 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"N\u00fa\u00f1ez-Iglesias","sequence":"additional","affiliation":[{"name":"SNLLaboratory, School of Medicine and Dentistry, University of Santiago de Compostela, 15782 A Coru\u00f1a, Spain"},{"name":"Department of Psiquiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, 15782 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Paz Carreira","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology Center of Galicia, 15009 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Blanco Hortas","sequence":"additional","affiliation":[{"name":"Health Research Institute Foundation (FIDIS) of Santiago de Compostela, Lucus Augusti University Hospital, 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"\u00c1lvarez Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Clinical Analysis Laboratory, Department of Immunology, Lucus Augusti University Hospital, 27003 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6169-8356","authenticated-orcid":false,"given":"Silvia","family":"Nov\u00edo Mall\u00f3n","sequence":"additional","affiliation":[{"name":"SNLLaboratory, School of Medicine and Dentistry, University of Santiago de Compostela, 15782 A Coru\u00f1a, Spain"},{"name":"Department of Psiquiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, 15782 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Zaera","sequence":"additional","affiliation":[{"name":"Clinical Analysis Laboratory, Department of Immunology, Lucus Augusti University Hospital, 27003 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Freire-Garabal N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"SNLLaboratory, School of Medicine and Dentistry, University of Santiago de Compostela, 15782 A Coru\u00f1a, Spain"},{"name":"Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/apt.14490","article-title":"Review article: Coeliac disease in later life must not be missed","volume":"47","author":"Collin","year":"2018","journal-title":"Aliment. 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