{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:00:12Z","timestamp":1781154012850,"version":"3.54.1"},"reference-count":48,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Hidradenitis suppurativa (HS) is a chronic skin disease that profoundly affects patients\u2019 quality of life (QoL) and sexuality. Few data are available on the impact of HS on patients\u2019 partners. We aimed to explore the QoL and sexual function of patients\u2019 partners and the factors associated with their impairment and to compare the QoL and sexual function of single patients and those in a stable relationship. We conducted a cross-sectional study at Hospital Universitario Virgen de las Nieves (Granada, Spain) and at the Wroclaw Medical University (Wroclaw, Poland). Patients over the age of 16 years attending their scheduled follow-up and their partners, if any, were included. The Dermatology Life Quality Index (DLQI) and the Family Dermatology Life Quality Index (FDLQI) were used to estimate the QoL of patients and partners, respectively. The FSFI-6 was used to determine sexual dysfunction in women and the IIEF-5 for erectile dysfunction in men. Thirty-four single patients and twenty-eight patients in a stable relationship and their partners were included. Patients had a very large impact (DLQI 12.5 \u00b1 7.5) and their partners a moderate impact (FDLQI 10.3 \u00b1 7.1) in their QoL due to HS. Women with HS had a high prevalence of sexual dysfunction (13\/32, 40.6%) and men of erectile dysfunction (19\/30, 63.3%). Male partners also had a high prevalence of erectile dysfunction (10\/17, 58.8%), while only one female partner had sexual dysfunction (1\/11, 9.1%). Factors related to disease severity, intensity of symptoms and body mass index were associated with poorer QoL in partners and time of disease evolution with greater erectile dysfunction in male partners. In conclusion, HS not only profoundly affects the QoL and sexuality of patients but also of their partners. Several risk factors have been identified, which should be taken into account in the holistic approach of the disease.<\/jats:p>","DOI":"10.3390\/ijerph20010389","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T04:42:47Z","timestamp":1672116167000},"page":"389","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Sexual Dysfunction and Quality of Life in Patients with Hidradenitis Suppurativa and Their Partners"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7579-4931","authenticated-orcid":false,"given":"Carlos","family":"Cuenca-Barrales","sequence":"first","affiliation":[{"name":"Hidradenitis Suppurativa Clinic, Dermatology Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"},{"name":"TECe19-Dermatolog\u00eda Cl\u00ednica y Traslacional Investigation Group, Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4035-7955","authenticated-orcid":false,"given":"Trinidad","family":"Montero-Vilchez","sequence":"additional","affiliation":[{"name":"Hidradenitis Suppurativa Clinic, Dermatology Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"},{"name":"TECe19-Dermatolog\u00eda Cl\u00ednica y Traslacional Investigation Group, Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4722-8531","authenticated-orcid":false,"given":"Piotr K","family":"Krajewski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, 50-368 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0766-6342","authenticated-orcid":false,"given":"Jacek C","family":"Szepietowski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, 50-368 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Matusiak","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, 50-368 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4186-1435","authenticated-orcid":false,"given":"Salvador","family":"Arias-Santiago","sequence":"additional","affiliation":[{"name":"Hidradenitis Suppurativa Clinic, Dermatology Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"},{"name":"TECe19-Dermatolog\u00eda Cl\u00ednica y Traslacional Investigation Group, Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, 18012 Granada, Spain"},{"name":"School of Medicine, Department of Dermatology, University of Granada, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6882-2113","authenticated-orcid":false,"given":"Alejandro","family":"Molina-Leyva","sequence":"additional","affiliation":[{"name":"Hidradenitis Suppurativa Clinic, Dermatology Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"},{"name":"TECe19-Dermatolog\u00eda Cl\u00ednica y Traslacional Investigation Group, Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kurzen, H., Kurokawa, I., Jemec, G.B., Emtestam, L., Sellheyer, K., Giamarellos-Bourboulis, E.J., Nagy, I., Bechara, F.G., Sartorius, K., and Lapins, J. (2008). What causes hidradenitis suppurativa?. Exp. Dermatol., 17.","DOI":"10.1111\/j.1600-0625.2008.00712.x"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/jdv.16677","article-title":"Hidradenitis suppurativa: An update on epidemiology, phenotypes, diagnosis, pathogenesis, comorbidities and quality of life","volume":"35","author":"Nguyen","year":"2021","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_3","first-page":"830","article-title":"Color Doppler as a tool for correlating vascularization and pain in hidradenitis suppurativa lesions","volume":"25","author":"Nazzaro","year":"2019","journal-title":"Skin Res. Technol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000502139","article-title":"Pruritus and Malodour in Patients with Hidradenitis Suppurativa: Impact on Quality of Life and Clinical Features Associated with Symptom Severity","volume":"236","year":"2020","journal-title":"Dermatology"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Scala, E., Cacciapuoti, S., Garzorz-Stark, N., Megna, M., Marasca, C., Seiringer, P., Volz, T., Eyerich, K., and Fabbrocini, G. (2021). Hidradenitis Suppurativa: Where We Are and Where We Are Going. Cells, 10.","DOI":"10.3390\/cells10082094"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.5114\/ada.2022.119008","article-title":"Hidradenitis suppurativa: Bacteriological study in surgical treatment","volume":"39","author":"Gierek","year":"2022","journal-title":"Adv. Dermatol. Allergol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.5114\/ada.2022.114885","article-title":"Hidradenitis Suppurativa Quality of Life 24 (HSQoL-24) now available for Polish patients: Creation and validation of the Polish language version","volume":"39","author":"Krajewski","year":"2022","journal-title":"Adv. Dermatol. Allergol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Rymaszewska, J., Krajewski, P., Szcz\u0119ch, J., and Szepietowski, J. (2022). Depression and anxiety in hidradenitis suppurativa patients: A cross-sectional study among Polish patients. Adv. Dermatol. Allergol.","DOI":"10.5114\/ada.2022.119080"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1159\/000513044","article-title":"Implications of Hidradenitis Suppurativa Phenotypes in Cardiovascular Risk and Treatment Decisions: A Retrospective Cohort Study","volume":"237","year":"2021","journal-title":"Dermatology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jaad.2016.08.031","article-title":"Inflammatory bowel disease is associated with hidradenitis suppurativa: Results from a multicenter cross-sectional study","volume":"76","author":"Deckers","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1111\/bjd.16603","article-title":"Profound consequences of hidradenitis suppurativa: A review","volume":"183","author":"Matusiak","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_12","first-page":"279","article-title":"Association Between Hidradenitis Suppurativa and Metabolic Syndrome: A Systematic Review and Meta-analysis","volume":"110","year":"2019","journal-title":"Actas Dermosifiliogr."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Shukla, R., Karagaiah, P., Patil, A., Farnbach, K., Ortega-Loayza, A.G., Tzellos, T., Szepietowski, J.C., Giulini, M., Schepler, H., and Grabbe, S. (2022). Surgical Treatment in Hidradenitis Suppurativa. J. Clin. Med., 11.","DOI":"10.3390\/jcm11092311"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Gierek, M., Labus, W., Kitala, D., Lorek, A., Ochala-Gierek, G., Zagorska, K.M., Waniczek, D., Szyluk, K., and Niemiec, P. (2022). Human Acellular Dermal Matrix in Reconstructive Surgery\u2014A Review. Biomedicines, 10.","DOI":"10.3390\/biomedicines10112870"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jaad.2014.03.039","article-title":"Quality of life in persons living with psoriasis patients","volume":"71","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"478","DOI":"10.2340\/00015555-2561","article-title":"Impairment of Sexual Life in 3485 Dermatological Outpatients From a Multicentre Study in 13 European Countries","volume":"97","author":"Sampogna","year":"2017","journal-title":"Acta Derm. Venereol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jaad.2011.10.024","article-title":"Profound disturbances of sexual health in patients with acne inversa","volume":"67","author":"Kurek","year":"2012","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ijwd.2017.10.007","article-title":"Quality of life and sexual health in patients with hidradenitis suppurativa","volume":"4","author":"Alavi","year":"2018","journal-title":"Int. J. Womens Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Gierek, M., Kitala, D., Labus, W., Szyluk, K., Niemiec, P., and Ochala-Gierek, G. (2022). Impact of Hidradenitis Suppurativa Surgical Treatment on Health-Related Life Quality. J. Clin. Med., 11.","DOI":"10.3390\/jcm11154327"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/bjd.15280","article-title":"The burden of common skin diseases assessed with the EQ5D: A European multicentre study in 13 countries","volume":"176","author":"Balieva","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1468-3083.2012.04468.x","article-title":"Depression in patients with hidradenitis suppurativa","volume":"27","author":"Onderdijk","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/jdv.16726","article-title":"Sexual impairment in patients with hidradenitis suppurativa: A systematic review","volume":"35","author":"Szepietowski","year":"2021","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_23","first-page":"61","article-title":"Sexual Dysfunction in Patients with Hidradenitis Suppurativa: A Systematic Review and Meta-Analysis","volume":"14","author":"Seetan","year":"2021","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12958-019-0557-9","article-title":"Lifestyles and sexuality in men and women: The gender perspective in sexual medicine","volume":"18","author":"Mollaioli","year":"2020","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000501905","article-title":"Risk Factors of Sexual Dysfunction in Patients with Hidradenitis Suppurativa: A Cross-Sectional Study","volume":"236","year":"2020","journal-title":"Dermatology"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Cuenca-Barrales, C., and Molina-Leyva, A. (2020). Sexuality in Patients with Hidradenitis Suppurativa: Beliefs, Behaviors and Needs. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17238808"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Cuenca-Barrales, C., Ruiz-Villaverde, R., and Molina-Leyva, A. (2019). Sexual Distress in Patients with Hidradenitis Suppurativa: A Cross-Sectional Study. J. Clin. Med., 8.","DOI":"10.3390\/jcm8040532"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1111\/jdv.16255","article-title":"Psychosocial Burden of Hidradenitis Suppurativa Patients\u2019 Partners","volume":"34","author":"Wlodarek","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/bjd.15748","article-title":"Development and Validation of the International Hidradenitis Suppurativa Severity Score System (IHS4), a Novel Dynamic Scoring System to Assess HS Severity","volume":"177","author":"Zouboulis","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/jdv.12966","article-title":"European S1 guideline for the treatment of hidradenitis suppurativa\/acne inversa","volume":"29","author":"Zouboulis","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1365-2133.2006.07617.x","article-title":"The Family Dermatology Life Quality Index: Measuring the secondary impact of skin disease","volume":"156","author":"Basra","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1365-2230.1994.tb01167.x","article-title":"Dermatology Life Quality Index (DLQI)\u2014A Simple Practical Measure for Routine Clinical Use","volume":"19","author":"Finlay","year":"1994","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1743-6109.2009.01635.x","article-title":"Development and validation of a 6-item version of the female sexual function index (FSFI) as a diagnostic tool for female sexual dysfunction","volume":"7","author":"Isidori","year":"2010","journal-title":"J. Sex. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.jaad.2009.09.021","article-title":"Hidradenitis suppurativa markedly decreases quality of life and professional activity","volume":"62","author":"Matusiak","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1159\/000453355","article-title":"Quality of Life and Psychosocial Implications in Patients with Hidradenitis Suppurativa","volume":"232","author":"Kouris","year":"2016","journal-title":"Dermatology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2340\/00015555-0866","article-title":"Psychophysical aspects of hidradenitis suppurativa","volume":"90","author":"Matusiak","year":"2010","journal-title":"Acta Derm. Venereol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/jdv.12567","article-title":"Psychiatric comorbidities in 3207 patients with hidradenitis suppurativa","volume":"29","author":"Shavit","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/bjd.14922","article-title":"A pilot study of unemployment in patients with hidradenitis suppurativa in Denmark","volume":"176","author":"Thorlacius","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jid.2017.09.008","article-title":"Increased Suicide Risk in Patients with Hidradenitis Suppurativa","volume":"138","author":"Thorlacius","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1001\/jamadermatol.2017.6058","article-title":"Association of Hidradenitis Suppurativa with Body Image","volume":"154","author":"Jost","year":"2018","journal-title":"JAMA Dermatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s10508-007-9205-0","article-title":"Body concerns in and out of the bedroom: Implications for sexual pleasure and problems","volume":"36","author":"Sanchez","year":"2007","journal-title":"Arch. Sex. Behav."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Ramos-Alejos-Pita, C., Arias-Santiago, S., and Molina-Leyva, A. (2020). Quality of Life in Cohabitants of Patients with Hidradenitis Suppurativa: A Cross-Sectional Study. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17166000"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1111\/jdv.12600","article-title":"Comparison of the impairment of family quality of life assessed by disease-specific and dermatology-specific instruments in children with atopic dermatitis","volume":"29","author":"Chernyshov","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s40257-013-0037-5","article-title":"Quality of life in family members of vitiligo patients: A questionnaire study in Saudi Arabia","volume":"14","author":"Binshabaib","year":"2013","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/j.1468-3083.2012.04682.x","article-title":"The Evaluation of Family Impact of Recessive Dystrophic Epidermolysis Bullosa Using the Italian Version of the Family Dermatology Life Quality Index","volume":"27","author":"Sampogna","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/wrr.12326","article-title":"Quality of life in Greek family members living with leg ulcer patients","volume":"23","author":"Kouris","year":"2015","journal-title":"Wound Repair Regen."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2340\/00015555-2967","article-title":"Influence of Itch and Pain on Sleep Quality in Patients with Hidradenitis Suppurativa","volume":"98","author":"Kaaz","year":"2018","journal-title":"Acta Derm. Venereol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s40257-017-0280-2","article-title":"Assessing Pruritus in Hidradenitis Suppurativa: A Cross-Sectional Study","volume":"18","author":"Vossen","year":"2017","journal-title":"Am. J. Clin. Dermatol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/1\/389\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:51:59Z","timestamp":1760147519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/1\/389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,26]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["ijerph20010389"],"URL":"https:\/\/doi.org\/10.3390\/ijerph20010389","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,26]]}}}