{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:14:07Z","timestamp":1793261647821,"version":"4.5.0"},"reference-count":41,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Fibromyalgic Syndrome is an important public health burden and affects up to 5% of the world population. It requires a complex treatment plan, possibly including antidepressants, anticonvulsants and benzodiazepines, which may in turn affect the patients\u2019 quality of life: hence the need to find additional therapies. The current pilot randomized-controlled study analyzes the effect of electromagnetic field locally administered as add-on therapy in the treatment of cervico-facial pain in patients with fibromyalgic syndrome. 17 patients were selected and low-frequency electromagnetic field was applied via small patches worn in the neck area, between vertebrae C3\u2013C4. Patients were divided into 2 groups, Treated, receiving the therapy, and Placebo, receiving an identical device which was not working,, with respectively 8 and 9 patients. The whole follow up period was 12 months and facial\/cervical pain levels were rated using VAS scale. Significant differences were found between patients who received placebo and those treated. Treated patients showed statistically significant improvements in facial\/cervical pain at each time-point, both with respect to the previous one and if compared to placebo. In conclusion, low frequency electromagnetic field emerged as beneficial in treating cervico-facial pain in patients with Fibromyalgic syndrome, with no side effects.<\/jats:p>","DOI":"10.3390\/ijerph20010391","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T04:42:47Z","timestamp":1672116167000},"page":"391","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chronic Facial Pain in Fibromyalgia: May ElectroMagnetic Field Represent a Promising New Therapy? A Pilot Randomized-Controlled Study"],"prefix":"10.3390","volume":"20","author":[{"given":"Marco","family":"Storari","sequence":"first","affiliation":[{"name":"Department of Surgical Science, College of Dentistry, University of Cagliari, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Zerman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dentistry, Pediatrics and Gynaecology, University of Verona, 37124 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Salis","sequence":"additional","affiliation":[{"name":"Department of Surgical Science, College of Dentistry, University of Cagliari, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4563-9804","authenticated-orcid":false,"given":"Enrico","family":"Spinas","sequence":"additional","affiliation":[{"name":"Department of Surgical Science, College of Dentistry, University of Cagliari, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/acr.20140","article-title":"The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity","volume":"62","author":"Wolfe","year":"2010","journal-title":"Arthritis Care Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.mayocp.2015.03.014","article-title":"Fibromyalgia and related conditions","volume":"90","author":"Clauw","year":"2015","journal-title":"Mayo Clin. Proc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/art.38905","article-title":"The prevalence of fibromyalgia in the general population: A comparison of the American College of Rheumatology 1990, 2010, and modified 2010 classification criteria","volume":"67","author":"Jones","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1001\/jama.2014.3266","article-title":"Fibromyalgia: A Clinical Review","volume":"311","author":"Clauw","year":"2014","journal-title":"JAMA"},{"key":"ref_5","first-page":"S102","article-title":"Fibromyalgia: Gender differences and sleep-disordered breathing","volume":"31","author":"Prados","year":"2013","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_6","first-page":"6","article-title":"Fibromyalgia syndrome: Review of clinical presentation, pathogenesis, outcome measures, and treatment","volume":"75","author":"Mease","year":"2005","journal-title":"J. Rheumatol. Suppl."},{"key":"ref_7","first-page":"176","article-title":"What are the key symptoms of fibromyalgia? Results of a survey of the German Fibromyalgia Association","volume":"22","author":"Zimmer","year":"2008","journal-title":"Schmerz"},{"key":"ref_8","first-page":"17","article-title":"Fibromyalgia and bipolar disorder: Extent of comorbidity and therapeutic implications","volume":"31","author":"Carinci","year":"2017","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.berh.2015.04.022","article-title":"Physical exercise as non-pharmacological treatment of chronic pain: Why and when","volume":"29","author":"Ambrose","year":"2015","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.3899\/jrheum.100104","article-title":"Efficacy of cognitive-behavioral therapies in fibromyalgia syndrome\u2014A systematic review and metaanalysis of randomized controlled trials","volume":"37","author":"Bernardy","year":"2010","journal-title":"J. Rheumatol."},{"key":"ref_11","first-page":"CD007115","article-title":"Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia","volume":"1","author":"Lunn","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.tripleo.2007.09.030","article-title":"Use of topical medication in orofacial neuropathic pain: A retrospective study","volume":"105","author":"Heir","year":"2008","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"17002","DOI":"10.1038\/nrdp.2017.2","article-title":"Neuropathic pain","volume":"3","author":"Colloca","year":"2017","journal-title":"Nat. Rev. Dis. Primer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neucli.2006.08.002","article-title":"The use of repetitive transcranial magnetic stimulation (rTMS) in chronic neuropathic pain","volume":"36","author":"Lefaucheur","year":"2006","journal-title":"Neurophysiol. Clin. Clin. Neurophysiol."},{"key":"ref_15","first-page":"CD008208","article-title":"Non-invasive brain stimulation techniques for chronic pain","volume":"4","author":"Marston","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.2147\/JPR.S168705","article-title":"Non-invasive brain stimulation in chronic orofacial pain: A systematic review","volume":"11","author":"Guay","year":"2018","journal-title":"J. Pain Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/(SICI)1521-186X(1998)19:1<46::AID-BEM5>3.0.CO;2-4","article-title":"Effect of sinusoidally varying magnetic fields on cell proliferation and adenosine deaminase specific activity","volume":"19","author":"Katsir","year":"1998","journal-title":"Bioelectromagnetics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1039\/b212636b","article-title":"Interactions of zero-frequency and oscillating magnetic fields with biostructures and biosystems","volume":"2","author":"Volpe","year":"2003","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/0304-4165(85)90255-7","article-title":"Modulation of collagen production in cultured fibroblasts by a low-frequency, pulsed magnetic field","volume":"838","author":"Murray","year":"1985","journal-title":"Biochim. Biophys. Acta BBA Gen. Subj."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/00003086-198312000-00043","article-title":"Effects of pulsing electromagnetic fields on bone growth and articular cartilage","volume":"181","author":"Smith","year":"1983","journal-title":"Clin. Orthop."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"10834","DOI":"10.1038\/s41598-017-11090-7","article-title":"Effects of low-intensity pulsed electromagnetic fields on bone microarchitecture, mechanical strength and bone turnover in type 2 diabetic db\/db mice","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Lin, J.C. (1989). Biological Effects of Radio Frequency Electromagnetic Radiation. Electromagnetic Interaction with Biological Systems, Springer US.","DOI":"10.1007\/978-1-4684-8059-7"},{"key":"ref_23","first-page":"13","article-title":"Improved Endurance Gain in BALB\/C Mice by a Nanotechnology Medical Device","volume":"6","author":"Altobello","year":"2018","journal-title":"Int. J. Biomed. Mater. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.11648\/j.jb.20180201.14","article-title":"Reduction by a Nanotechnology Device of Serum Lactate Levels and Heart Rate in Athletes Undergoing to Resistance Exercises","volume":"2","author":"Ara","year":"2018","journal-title":"J. Biomater."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Storari, M., Zerman, N., and Spinas, E. (2022). Local Administration of ElectroMagnetic Field as Add-On Therapy in the Treatment of Chronic Facial Pain: A Pilot Study. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19074123"},{"key":"ref_26","unstructured":"European Medicines Agency, Committee for Human Medicinal Products (2016). ICH: E 6 (R2): Guideline for Good Clinical Practice, European Medicines Agency, Committee for Human Medicinal Products."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0140-6736(00)04337-3","article-title":"The CONSORT statement: Revised recommendations for improving the quality of reports of parallel-group randomised trials","volume":"357","author":"Moher","year":"2001","journal-title":"Lancet"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6","DOI":"10.11607\/jop.1151","article-title":"Diagnostic Criteria for Temporomandibular Disorders (DC\/TMD) for Clinical and Research Applications: Recommendations of the International RDC\/TMD Consortium Network* and Orofacial Pain Special Interest Group","volume":"28","author":"Schiffman","year":"2014","journal-title":"J. Oral Facial. Pain Headache"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"World Medical Association (2013). World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. JAMA, 310, 2191.","DOI":"10.1001\/jama.2013.281053"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1017\/S0033291700009934","article-title":"Clinical applications of visual analogue scales: A critical review","volume":"18","author":"McCormack","year":"1988","journal-title":"Psychol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2307\/3001968","article-title":"Individual Comparisons by Ranking Methods","volume":"1","author":"Wilcoxon","year":"1945","journal-title":"Biom. Bull."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1214\/aoms\/1177730491","article-title":"On a Test of Whether One of Two Random Variables Is Stochastically Larger than the Other","volume":"18","author":"Mann","year":"1947","journal-title":"Ann. Math. Stat."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/15368370701580806","article-title":"Expanding use of pulsed electromagnetic field therapies","volume":"26","author":"Markov","year":"2007","journal-title":"Electromagn. Biol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.csm.2007.10.006","article-title":"Electromagnetic interventions in musculoskeletal disorders","volume":"27","author":"Bachl","year":"2008","journal-title":"Clin. Sports Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0140-6736(84)92219-0","article-title":"Pulsed electromagnetic field therapy of persistent rotator cuff tendinitis. A double-blind controlled assessment","volume":"1","author":"Binder","year":"1984","journal-title":"Lancet"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3928\/0147-7447-19900401-10","article-title":"Pulsed high frequency (27MHz) electromagnetic therapy for persistent neck pain. A double blind, placebo-controlled study of 20 patients","volume":"13","author":"Barry","year":"1990","journal-title":"Orthopedics"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"E641","DOI":"10.1097\/01.brs.0000184302.34509.48","article-title":"A Cochrane review of electrotherapy for mechanical neck disorders","volume":"30","author":"Kroeling","year":"2005","journal-title":"Spine"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1097\/AJP.0b013e3181a68a6c","article-title":"Low-frequency pulsed electromagnetic field therapy in fibromyalgia: A randomized, double-blind, sham-controlled clinical study","volume":"25","author":"Sutbeyaz","year":"2009","journal-title":"Clin. J. Pain"},{"key":"ref_39","first-page":"115","article-title":"Slow-frequency rTMS reduces fibromyalgia pain","volume":"7","author":"Sampson","year":"2006","journal-title":"Pain Med. Malden Mass"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.rbr.2016.10.004","article-title":"Prevalence of fibromyalgia: Literature review update","volume":"57","author":"Marques","year":"2017","journal-title":"Rev. Bras Reumatol. Engl. Ed."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s11916-013-0356-5","article-title":"Worldwide epidemiology of fibromyalgia","volume":"17","author":"Quieiroz","year":"2013","journal-title":"Curr. Pain Headache Rep."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/1\/391\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:52:02Z","timestamp":1760147522000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/1\/391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,26]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["ijerph20010391"],"URL":"https:\/\/doi.org\/10.3390\/ijerph20010391","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,26]]}}}