{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:46:01Z","timestamp":1787028361562,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Society of Diabetic Neuropathy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Lower extremity amputations (LEAs) are a feared complication of diabetes mellitus (DM). Here we evaluated the recent trends in DM-related LEAs in Romania. We collected data from a national database regarding minor and major LEAs performed between 2015 and 2019 in patients with DM admitted to a public hospital. Absolute numbers of LEAs were presented by year, diabetes type, sex and age; incidence rates of LEAs in the general population were also calculated. Over the study period, 40,499 LEAs were recorded nationwide (83.16% in persons with type 2 DM [T2DM]); on average, the number of LEAs increased by 5.7%\/year. This trend was driven by an increased number of LEAs in patients with T2DM; in patients with type 1 DM (T1DM), LEAs decreased over the study period. In patients with T2DM, the increase in minor LEAs was more pronounced than that in major LEAs. The overall number of LEAs showed an increasing trend with age (r = 0.72), which was most pronounced in patients aged \u226570 years. Men had a higher frequency of LEAs than women, regardless of DM type. These data support renewed efforts to prevent and decrease the burden of amputations among patients with DM.<\/jats:p>","DOI":"10.3390\/ijerph20010557","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T02:56:50Z","timestamp":1672282610000},"page":"557","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diabetes-Related Lower Extremity Amputations in Romania: Patterns and Changes between 2015 and 2019"],"prefix":"10.3390","volume":"20","author":[{"given":"Hora\u0163iu","family":"Coman","sequence":"first","affiliation":[{"name":"Vascular Surgery Clinic, Cluj County Emergency Hospital, 400347 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9319-7428","authenticated-orcid":false,"given":"Bogdan","family":"Stancu","sequence":"additional","affiliation":[{"name":"Second Department of Surgery, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norina A.","family":"G\u00e2van","sequence":"additional","affiliation":[{"name":"W\u00f6rwag Pharma Romania SRL, 400267 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank L.","family":"Bowling","sequence":"additional","affiliation":[{"name":"Developmental Biomedicine Research Group, The University of Manchester, Manchester M13 9PL, UK"},{"name":"Department of Vascular Surgery and Reconstructive Microsurgery, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Podariu","sequence":"additional","affiliation":[{"name":"Vascular Surgery Clinic, Cluj County Emergency Hospital, 400347 Cluj-Napoca, Romania"},{"name":"\u201cNicolae St\u0103ncioiu\u201d Heart Institute, 400001 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosmina I.","family":"Bondor","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Biostatistics, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Radulian","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucure\u015fti, Romania"},{"name":"\u201cProf. Dr. Nicolae Paulescu\u201d National Institute for Diabetes, Nutrition and Metabolic Diseases, 030167 Bucuresti, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. 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