{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:41:56Z","timestamp":1779943316678,"version":"3.53.1"},"reference-count":65,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82000085"],"award-info":[{"award-number":["82000085"]}]},{"name":"National Natural Science Foundation of China","award":["81871601"],"award-info":[{"award-number":["81871601"]}]},{"name":"National Natural Science Foundation of China","award":["21XD1402800"],"award-info":[{"award-number":["21XD1402800"]}]},{"name":"National Natural Science Foundation of China","award":["22ZR1452200"],"award-info":[{"award-number":["22ZR1452200"]}]},{"name":"Program of Shanghai Academic Research Leader","award":["82000085"],"award-info":[{"award-number":["82000085"]}]},{"name":"Program of Shanghai Academic Research Leader","award":["81871601"],"award-info":[{"award-number":["81871601"]}]},{"name":"Program of Shanghai Academic Research Leader","award":["21XD1402800"],"award-info":[{"award-number":["21XD1402800"]}]},{"name":"Program of Shanghai Academic Research Leader","award":["22ZR1452200"],"award-info":[{"award-number":["22ZR1452200"]}]},{"name":"Shanghai Natural Science Foundation","award":["82000085"],"award-info":[{"award-number":["82000085"]}]},{"name":"Shanghai Natural Science Foundation","award":["81871601"],"award-info":[{"award-number":["81871601"]}]},{"name":"Shanghai Natural Science Foundation","award":["21XD1402800"],"award-info":[{"award-number":["21XD1402800"]}]},{"name":"Shanghai Natural Science Foundation","award":["22ZR1452200"],"award-info":[{"award-number":["22ZR1452200"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Acute lung injury (ALI)\/acute respiratory distress syndrome (ARDS) is a clinical syndrome associated with mitochondria and lacks effective preventive and therapeutic measures. This bibliometric study aims to gain insight into the scientific findings regarding mitochondria in ALI\/ARDS. Methods: We retrieved the Science Citation Index Expanded (SCIE) of the Web of Science Core Collection (WoSCC) for mitochondria in ALI\/ARDS publications from 2012\u20132021. VOSviewer, CiteSpace (5.8. R3) and Bibliometrix (3.1.4) R package were used for further analysis and visualization. Result: A total of 756 English-language articles and reviews were identified. The annual number of publications presented a rapidly developing trend. China was the most productive and cited country, and the USA had the greatest impact. In the keyword co-occurring network, the terms \u201cacute lung injury\u201d, \u201coxidative stress\u201d, \u201cinflammation\u201d, \u201cmitochondria\u201d and \u201capoptosis\u201d occurred most frequently. The co-citation network revealed that #1 mesenchymal stromal cell and #3 endothelial cell had the most bursts of citations. In addition, research hotspots have shifted from \u201cpotential therapeutic treatments\u201d and \u201cmitochondrial DNA (mtDNA)\u201d to \u201cendothelial cell\u201d and \u201cmesenchymal stromal cell (MSC)\u201d. Conclusion: This bibliometric analysis reveals the research directions and frontier hotspots of mitochondria in ALI\/ARDS, which has shown a rapid growth trend in annual publication numbers. mtDNA, mitophagy, and apoptosis have been the most active research areas, while studies on mitochondrial transfer in stem cells have become a hot topic in recent years.<\/jats:p>","DOI":"10.3390\/ijerph20010585","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T03:26:11Z","timestamp":1672370771000},"page":"585","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Global Research Trends and Hotspots on Mitochondria in Acute Lung Injury from 2012\u20132021: A Bibliometric Analysis"],"prefix":"10.3390","volume":"20","author":[{"given":"Song","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoran","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanfu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7631-4266","authenticated-orcid":false,"given":"Meiyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8665-2621","authenticated-orcid":false,"given":"Juan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanli","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3352-7162","authenticated-orcid":false,"given":"Xin","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1164\/rccm.202108-1908ST","article-title":"A Research Agenda for Precision Medicine in Sepsis and Acute Respiratory Distress Syndrome: An Official American Thoracic Society Research Statement","volume":"204","author":"Shah","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_2","unstructured":"ARDS Definition of Task Force, Ranieri, V.M., Rubenfeld, G.D., Thompson, B.T., Ferguson, N.D., Caldwell, E., Fan, E., Camporota, L., and Slutsky, A.S. (2012). Acute Respiratory Distress Syndrome: The Berlin Definition. JAMA, 307, 2526\u20132533."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1001\/jama.2016.0291","article-title":"Epidemiology, Patterns of Care, and Mortality for Patients with Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries","volume":"315","author":"Bellani","year":"2016","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0140-6736(21)00439-6","article-title":"Acute Respiratory Distress Syndrome","volume":"398","author":"Meyer","year":"2021","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41572-019-0069-0","article-title":"Acute Respiratory Distress Syndrome","volume":"5","author":"Matthay","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2003317","DOI":"10.1183\/13993003.03317-2020","article-title":"Outcome of Acute Hypoxaemic Respiratory Failure: Insights from the Lung Safe Study","volume":"57","author":"Pham","year":"2021","journal-title":"Eur. Respir. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1089\/jamp.2009.0775","article-title":"Acute Lung Injury: Epidemiology, Pathogenesis, and Treatment","volume":"23","author":"Johnson","year":"2010","journal-title":"J. Aerosol. Med. Pulm. Drug Deliv."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"622602","DOI":"10.3389\/fimmu.2020.622602","article-title":"Mitochondrial Regulation of Macrophage Response against Pathogens","volume":"11","author":"Choudhuri","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100922","DOI":"10.1016\/j.mam.2020.100922","article-title":"Mitochondria Orchestrate Macrophage Effector Functions in Atherosclerosis","volume":"77","author":"Dumont","year":"2021","journal-title":"Mol. Asp. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.smim.2016.10.004","article-title":"Integrating Immunometabolism and Macrophage Diversity","volume":"28","author":"Artyomov","year":"2016","journal-title":"Semin. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.3389\/fimmu.2019.02461","article-title":"Pivotal Role of Mitochondria in Macrophage Response to Bacterial Pathogens","volume":"10","author":"Ramond","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"100904","DOI":"10.1016\/j.jbc.2021.100904","article-title":"Mitochondrial Metabolism Regulates Macrophage Biology","volume":"297","author":"Wang","year":"2021","journal-title":"J. Biol. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/cr.2017.155","article-title":"Mitochondrial Metabolism and Cancer","volume":"28","author":"Porporato","year":"2018","journal-title":"Cell. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41586-022-04765-3","article-title":"Defining Mitochondrial Protein Functions through Deep Multiomic Profiling","volume":"606","author":"Rensvold","year":"2022","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"119876","DOI":"10.1016\/j.lfs.2021.119876","article-title":"Mitochondrial Dynamics and Mitophagy in Lung Disorders","volume":"284","author":"Sharma","year":"2021","journal-title":"Life Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pharmthera.2016.06.019","article-title":"Mitochondria dysfunction: A novel therapeutic target in pathological lung remodeling or bystander?","volume":"166","author":"Rowlands","year":"2016","journal-title":"Pharm. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.biocel.2016.07.026","article-title":"Mitochondrial Redox System, Dynamics, and Dysfunction in Lung Inflammaging and Copd","volume":"81","author":"Lerner","year":"2016","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12968-016-0303-9","article-title":"Top 100 Cited Articles in Cardiovascular Magnetic Resonance: A Bibliometric Analysis","volume":"18","author":"Khan","year":"2016","journal-title":"J. Cardiovasc. Magn. Reason."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"110012","DOI":"10.1016\/j.jclinane.2020.110012","article-title":"Publication Trends and Hot Spots in Postoperative Cognitive Dysfunction Research: A 20-Year Bibliometric Analysis","volume":"67","author":"Chen","year":"2020","journal-title":"J. Clin. Anesth."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1586\/17476348.2015.1103649","article-title":"Bibliometric Analysis of the Top 50 Cited Respiratory Articles","volume":"9","author":"Seriwala","year":"2015","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_21","first-page":"8787394","article-title":"Current Trends in Research on Bone Regeneration: A Bibliometric Analysis","volume":"2020","author":"Huang","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11657-018-0534-5","article-title":"Osteoporosis in Postmenopausal Women in This Decade: A Bibliometric Assessment of Current Research and Future Hotspots","volume":"13","author":"Qiu","year":"2018","journal-title":"Arch. Osteoporos."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/j.arth.2020.11.038","article-title":"Bibliometric Analysis of the Top-Cited Articles on Unicompartmental Knee Arthroplasty","volume":"36","author":"He","year":"2021","journal-title":"J. Arthroplast."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1159\/000516185","article-title":"A Bibliometric Analysis of the One Hundred Most Cited Studies in Psychosomatic Research","volume":"90","author":"Shah","year":"2021","journal-title":"Psychother. Psychosom."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ogunsakin, R.E., Ebenezer, O., and Ginindza, T.G. (2022). A Bibliometric Analysis of the Literature on Norovirus Disease from 1991\u20132021. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19052508"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ogunsakin, R.E., Ebenezer, O., Jordaan, M.A., Shapi, M., and Ginindza, T.G. (2022). Mapping Scientific Productivity Trends and Hotspots in Remdesivir Research Publications: A Bibliometric Study from 2016 to 2021. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19148845"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"697633","DOI":"10.3389\/fpubh.2021.697633","article-title":"Bibliometric Review to Explore Emerging High-Intensity Interval Training in Health Promotion: A New Century Picture","volume":"9","author":"You","year":"2021","journal-title":"Front Public Health"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Igwaran, A., and Edoamodu, C.E. (2021). Bibliometric Analysis on Tuberculosis and Tuberculosis-Related Research Trends in Africa: A Decade-Long Study. Antibiotics, 10.","DOI":"10.3390\/antibiotics10040423"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The Measurement of Observer Agreement for Categorical Data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"669539","DOI":"10.3389\/fimmu.2021.669539","article-title":"Global Trends in Research of Macrophages Associated with Acute Lung Injury over Past 10 Years: A Bibliometric Analysis","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"744308","DOI":"10.3389\/fonc.2021.744308","article-title":"Status Quo and Research Trends of Craniopharyngioma Research: A 10-Year Bibliometric Analyses (from 2011 to 2020)","volume":"11","author":"Li","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"16569","DOI":"10.1073\/pnas.0507655102","article-title":"An Index to Quantify an Individual\u2019s Scientific Research Output","volume":"102","author":"Hirsch","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00005-009-0001-5","article-title":"New Developments in the Use of Citation Analysis in Research Evaluation","volume":"57","author":"Moed","year":"2009","journal-title":"Arch. Immunol. Ex"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e1918007","DOI":"10.1001\/jamanetworkopen.2019.18007","article-title":"A Bibliometric Analysis of Top-Cited Journal Articles in Obstetrics and Gynecology","volume":"2","author":"Brandt","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.wneu.2011.01.015","article-title":"Finding a Way through the Scientific Literature: Indexes and Measures","volume":"76","author":"Jones","year":"2011","journal-title":"World Neurosurg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s11845-018-1936-5","article-title":"Current Concepts on Bibliometrics: A Brief Review About Impact Factor, Eigenfactor Score, Citescore, Scimago Journal Rank, Source-Normalised Impact Per Paper, H-Index, and Alternative Metrics","volume":"188","author":"Rios","year":"2019","journal-title":"Ir. J. Med. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software Survey: Vosviewer, a Computer Program for Bibliometric Mapping","volume":"84","author":"Waltman","year":"2010","journal-title":"Scientometrics"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"125627","DOI":"10.1016\/j.chemosphere.2019.125627","article-title":"Freshwater Microplastics Pollution: Detecting and Visualizing Emerging Trends Based on Citespace Ii","volume":"245","author":"Yao","year":"2020","journal-title":"Chemosphere"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1073\/pnas.0307513100","article-title":"Searching for Intellectual Turning Points: Progressive Knowledge Domain Visualization","volume":"101","author":"Chen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.4103\/1673-5374.255995","article-title":"Knowledge Domain and Emerging Trends in Alzheimer\u2019s Disease: A Scientometric Review Based on Citespace Analysis","volume":"14","author":"Liu","year":"2019","journal-title":"Neural. Regen. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"Bibliometrix: An R-Tool for Comprehensive Science Mapping Analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J. Informetr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1017\/dmp.2019.31","article-title":"Visualizing the History and Perspectives of Disaster Medicine: A Bibliometric Analysis","volume":"13","author":"Hao","year":"2019","journal-title":"Disaster Med. Public Health Prep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/asi.4630300404","article-title":"An Information Approach to Examining Developments in an Energy Technology: Coal Gasification","volume":"30","author":"Frame","year":"2014","journal-title":"J. Am. Soc. Inf. Sci. Technol."},{"key":"ref_44","first-page":"1","article-title":"Science Mapping: A Systematic Review of the Literature","volume":"2","author":"Chen","year":"2017","journal-title":"J. Data Inf. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/asi.22968","article-title":"Patterns of Connections and Movements in Dual-Map Overlays: A New Method of Publication Portfolio Analysis","volume":"65","author":"Chen","year":"2014","journal-title":"J. Assoc. Inf. Sci. Technol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nm.2736","article-title":"Mitochondrial Transfer from Bone-Marrow-Derived Stromal Cells to Pulmonary Alveoli Protects against Acute Lung Injury","volume":"18","author":"Islam","year":"2012","journal-title":"Nat. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1002\/stem.2372","article-title":"Mitochondrial Transfer Via Tunneling Nanotubes Is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the in Vitro and in Vivo Models of Ards","volume":"34","author":"Jackson","year":"2016","journal-title":"Stem Cells"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1164\/rccm.201701-0170OC","article-title":"Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer","volume":"196","author":"Morrison","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.chest.2019.09.028","article-title":"Plasma Mitochondrial DNA Levels Are Associated with Ards in Trauma and Sepsis Patients","volume":"157","author":"Faust","year":"2020","journal-title":"Chest"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.freeradbiomed.2012.08.009","article-title":"Nrf2 Promotes Alveolar Mitochondrial Biogenesis and Resolution of Lung Injury in Staphylococcus Aureus Pneumonia in Mice","volume":"53","author":"Athale","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3109\/10715762.2014.906592","article-title":"Abnormal Mitochondrial Fusion-Fission Balance Contributes to the Progression of Experimental Sepsis","volume":"48","author":"Gonzalez","year":"2014","journal-title":"Free Radic. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"15118","DOI":"10.1074\/jbc.M113.536490","article-title":"Triggering Receptor Expressed on Myeloid Cells 1 (Trem-1)-Mediated Bcl-2 Induction Prolongs Macrophage Survival","volume":"289","author":"Yuan","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2014.10.582","article-title":"Redox Regulation of Mitophagy in the Lung During Murine Staphylococcus Aureus Sepsis","volume":"78","author":"Chang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.4049\/jimmunol.1400653","article-title":"Endothelial Pink1 Mediates the Protective Effects of Nlrp3 Deficiency During Lethal Oxidant Injury","volume":"192","author":"Zhang","year":"2014","journal-title":"J. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Nakahira, K., Kyung, S.-Y., Rogers, A.J., Gazourian, L., Youn, S., Massaro, A.F., Quintana, C., Osorio, J.C., Wang, Z., and Zhao, Y. (2013). Circulating Mitochondrial DNA in Patients in the Icu as a Marker of Mortality: Derivation and Validation. PLoS Med., 10.","DOI":"10.1371\/journal.pmed.1001577"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jss.2014.06.003","article-title":"Blood Transfusion Products Contain Mitochondrial DNA Damage-Associated Molecular Patterns: A Potential Effector of Transfusion-Related Acute Lung Injury","volume":"191","author":"Lee","year":"2014","journal-title":"J. Surg. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1182\/blood-2014-05-573543","article-title":"Platelets Release Mitochondria Serving as Substrate for Bactericidal Group Iia-Secreted Phospholipase A2 to Promote Inflammation","volume":"124","author":"Boudreau","year":"2014","journal-title":"Blood"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1097\/ALN.0000000000001333","article-title":"Heme Oxygenase-1\/Carbon Monoxide-Regulated Mitochondrial Dynamic Equilibrium Contributes to the Attenuation of Endotoxin-Induced Acute Lung Injury in Rats and in Lipopolysaccharide-Activated Macrophages","volume":"125","author":"Yu","year":"2016","journal-title":"Anesthesiology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1164\/rccm.201701-0107CP","article-title":"Years of Research in ARDS.Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic Value","volume":"196","author":"Laffey","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1080\/15376516.2019.1710888","article-title":"Critical Role of Mitochondrial Oxidative Stress in Acid Aspiration Induced Ali in Mice","volume":"30","author":"Puri","year":"2020","journal-title":"Toxicol. Mech. Methods"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12967-017-1306-5","article-title":"The Pathophysiological Role of Mitochondrial Oxidative Stress in Lung Diseases","volume":"15","author":"Liu","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"C258","DOI":"10.1152\/ajpcell.00224.2020","article-title":"Decoding Sars-Cov-2 Hijacking of Host Mitochondria in Covid-19 Pathogenesis","volume":"319","author":"Singh","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mito.2020.06.008","article-title":"Mitochondria and Microbiota Dysfunction in COVID-19 Pathogenesis","volume":"54","author":"Saleh","year":"2020","journal-title":"Mitochondrion"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.4049\/jimmunol.1303196","article-title":"Sars-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the Mavs\/Traf3\/Traf6 Signalosome","volume":"193","author":"Shi","year":"2014","journal-title":"J. Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Malavolta, M., Giacconi, R., Brunetti, D., Provinciali, M., and Maggi, F. (2020). Exploring the Relevance of Senotherapeutics for the Current Sars-Cov-2 Emergency and Similar Future Global Health Threats. Cells, 9.","DOI":"10.3390\/cells9040909"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/1\/585\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:55:29Z","timestamp":1760147729000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/1\/585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["ijerph20010585"],"URL":"https:\/\/doi.org\/10.3390\/ijerph20010585","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]}}}