{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:10:35Z","timestamp":1780600235939,"version":"3.54.1"},"reference-count":65,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001819","name":"International Rett syndrome Foundation","doi-asserted-by":"publisher","award":["3610"],"award-info":[{"award-number":["3610"]}],"id":[{"id":"10.13039\/100001819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Gross motor function in Rett syndrome (RTT) is always limited. The complex clinical picture typical of most people with RTT requires intensive and specific rehabilitation programs. Previous reports on remotely supervised motor activity programs suggested positive outcomes for this population. The current article describes the impact of a remote-supervised motor activity program carried out by family members of individuals with RTT on achieving rehabilitation goals and improving gross and fine motor functioning and daily physical activity. Methods: Forty subjects with RTT followed a three-month remotely supervised motor activity program carried out by their family members at home after a three-month baseline period. After the end of the intervention, a three-month wash-out period was implemented. Rehabilitation goal achievement, motor functioning, and level of daily physical activity were measured. Results: 82.4% of rehabilitation goals were achieved or overachieved. Participants\u2019 motor functioning and physical activity significantly increased after the intervention (p \u02c2 0.001). Improvements were maintained after the wash-out phase. Conclusions: The proposed intervention was effective for people with RTT of various ages and severity levels. The results highlight the need for lifelong, individualized, daily based, and professionally supervised rehabilitation possibilities for individuals with RTT.<\/jats:p>","DOI":"10.3390\/ijerph20010659","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T03:31:17Z","timestamp":1672371077000},"page":"659","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Individualized Remotely Supervised Motor Activity Programs Promote Rehabilitation Goal Achievement, Motor Functioning, and Physical Activity of People with Rett Syndrome\u2014A Single-Cohort Study"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9774-2964","authenticated-orcid":false,"given":"Alberto","family":"Romano","sequence":"first","affiliation":[{"name":"Department of Health System Management, Ariel University, Ariel 4070000, Israel"},{"name":"Airett Innovation and Research Center, 37122 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ippolito","sequence":"additional","affiliation":[{"name":"SMART Learning Center, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Favetta","sequence":"additional","affiliation":[{"name":"Movement Analysis and Robotics Laboratory, Intensive Neurorehabilitation and Robotics Department, Bambino Ges\u00f9 Children\u2019s Hospital, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meir","family":"Lotan","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Ariel University, Ariel 4070000, Israel"},{"name":"Israeli Rett Syndrome National Evaluation Team, Ramat Gan 5200100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Sender","family":"Moran","sequence":"additional","affiliation":[{"name":"Department of Health System Management, Ariel University, Ariel 4070000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1080\/0954026021000046119","article-title":"Prevalence of Pervasive Developmental Disorders in the British Nationwide Survey of Child Mental Health","volume":"15","author":"Fombonne","year":"2003","journal-title":"Int. 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