{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:44:54Z","timestamp":1787168694700,"version":"build-2736575974"},"reference-count":20,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine, Pharmacy, Science, and Technology \u201cGeorge Emil Palade\u201d of T\u00e2rgu Mure\u0219","award":["10126\/4\/17.12.2020"],"award-info":[{"award-number":["10126\/4\/17.12.2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The transposition of great arteries (TGA) is one of the most frequent and severe congenital heart diseases. After newborn stabilization and while pending surgical correction, echocardiographic monitoring with a careful evaluation of left ventricle (LV) performance is warranted. In this study, our objectives were (i) to compare myocardial function, assessed via speckle-tracking echocardiography, between neonates with TGA and neonates without TGA and (ii) to identify a strain parameter with a good discriminatory ability for TGA. We conducted a retrospective, single-center study. A total of 90 neonates were examined, of whom 66 were included (16 comprised the TGA group and 50 comprised the control group). The results of a bivariate analysis showed that classic echocardiography parameters displayed no significant differences between the two studied groups (p = 0.785 for EF, p = 0.286 for MAPSE and p = 0.315 for TAPSE). We found a statistically significant difference between the two groups for the mean values of the LVpGLS parameter (adjusted p = 0.0047), with impaired LV myocardium function being observed in the TGA group after adjusting for other covariates. Regarding segmental strain, the mean medial and apical inter-ventricular septum strain values were found to be significantly lower in the neonates with TGA than in the controls (95% CI for difference in means: [\u22126.45, \u22120.65], [\u22128.56, \u22121.97]). The results of an ROC analysis showed that LVpGLS had a significant ability to differentiate between neonates with TGA and controls (AUC = 0.712, 95% CI: [0.52, 0.903], p = 0.011). In conclusion, LVpGLS is a parameter with a significant discriminatory ability for LV dysfunction, and it is useful in the evaluation of ventricular myocardial function in newborns with TGA.<\/jats:p>","DOI":"10.3390\/ijerph20010674","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T04:07:09Z","timestamp":1672632429000},"page":"674","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impaired Speckle-Tracking-Derived Left Ventricular Longitudinal Strain Is Associated with Transposition of Great Arteries in Neonates: A Single-Center Study"],"prefix":"10.3390","volume":"20","author":[{"given":"Daniela","family":"Toma","sequence":"first","affiliation":[{"name":"Emergency Institute of Cardiovascular Diseases and Transplantation, 540139 T\u00e2rgu-Mure\u0219, Romania"},{"name":"Department of Pediatrics,\u201dGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu-Mure\u0219, 540139 T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorottya","family":"Gabor-Miklosi","sequence":"additional","affiliation":[{"name":"Emergency Institute of Cardiovascular Diseases and Transplantation, 540139 T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4321-6229","authenticated-orcid":false,"given":"Andreea","family":"Cerghit-Paler","sequence":"additional","affiliation":[{"name":"Emergency Institute of Cardiovascular Diseases and Transplantation, 540139 T\u00e2rgu-Mure\u0219, Romania"},{"name":"Department of Pediatrics,\u201dGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu-Mure\u0219, 540139 T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Corina","family":"\u0218uteu","sequence":"additional","affiliation":[{"name":"Emergency Institute of Cardiovascular Diseases and Transplantation, 540139 T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius-Catalin","family":"Cosma","sequence":"additional","affiliation":[{"name":"Emergency Institute of Cardiovascular Diseases and Transplantation, 540139 T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu","family":"M\u0103rginean","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology,\u201dGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu-Mure\u0219, 540139 T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4557-5364","authenticated-orcid":false,"given":"Mihaela","family":"Iancu","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Biostatistics, Faculty of Medicine, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy Cluj-Napoca, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Gozar","sequence":"additional","affiliation":[{"name":"Emergency Institute of Cardiovascular Diseases and Transplantation, 540139 T\u00e2rgu-Mure\u0219, Romania"},{"name":"Department of Pediatrics,\u201dGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu-Mure\u0219, 540139 T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"ref_1","unstructured":"David, A.K. 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