{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:13:05Z","timestamp":1790662385830,"version":"4.1.0"},"reference-count":31,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T00:00:00Z","timestamp":1672444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)","doi-asserted-by":"publisher","award":["2018\/22999-3"],"award-info":[{"award-number":["2018\/22999-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)","doi-asserted-by":"publisher","award":["2015\/18031-5"],"award-info":[{"award-number":["2015\/18031-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)","doi-asserted-by":"publisher","award":["101462\/2020-4"],"award-info":[{"award-number":["101462\/2020-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","doi-asserted-by":"publisher","award":["2018\/22999-3"],"award-info":[{"award-number":["2018\/22999-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","doi-asserted-by":"publisher","award":["2015\/18031-5"],"award-info":[{"award-number":["2015\/18031-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","doi-asserted-by":"publisher","award":["101462\/2020-4"],"award-info":[{"award-number":["101462\/2020-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Autonomic dysfunction, such as reduced vagally mediated heart rate variability, has been suggested in headache patients but is still uncertain when considering primary headache disorders. This study aims to compare the heart rate and blood pressure variability and baroreflex sensitivity between women with migraine and controls. A migraine (n = 20) and a control group (n = 20) of age-matched women without headache were evaluated. Heart rate variability was analyzed through frequency-domain using spectral analysis presenting variance, low-frequency (LF; 0.04\u20130.15 Hz) and high-frequency (HF; 0.15\u20130.4 Hz) bands and by time domain (root mean square of successive R-R interval differences, RMSSD). Blood pressure variability was analyzed with spectral analysis and baroreflex sensitivity with the sequence method. Migraine group had lower heart rate variability characterized by a reduction in total variance, LF oscillations (sympathetic\/vagal modulation) and HF oscillations (vagal modulation), and a reduction in SD and RMSSD compared to control group. No difference was found in the blood pressure variability analysis. Regarding baroreflex sensitivity, migraine group had decreased values of total gain, gain down and up compared to control group. Women with migraine exhibited autonomic modulation alterations, expressed by decreased values of heart rate variability and baroreflex sensitivity, but not by differences in blood pressure variability.<\/jats:p>","DOI":"10.3390\/ijerph20010763","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T04:17:38Z","timestamp":1672633058000},"page":"763","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impairment on Cardiovascular Autonomic Modulation in Women with Migraine"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-3387","authenticated-orcid":false,"given":"Denise Martineli","family":"Rossi","sequence":"first","affiliation":[{"name":"Department of Applied Physiotherapy, Federal University of Tri\u00e2ngulo Mineiro, Uberaba 38025-180, MG, Brazil"},{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeirao Preto 14049-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0009-0005","authenticated-orcid":false,"given":"Hugo Celso Dutra","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeirao Preto 14049-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora","family":"Bevilaqua-Grossi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeirao Preto 14049-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Carmona","family":"Vendramim","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeirao Preto 14049-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella Vieira","family":"Philbois","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeirao Preto 14049-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4442-2040","authenticated-orcid":false,"given":"Gabriela Ferreira","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Institute of Health Sciences, Universit\u00e4t zu L\u00fcbeck, 23562 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-4179","authenticated-orcid":false,"given":"Fab\u00edola","family":"Dach","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Behavioral Sciences, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeirao Preto 14049-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio","family":"Mascarenhas","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, Sao Carlos 13566-590, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamaria Siriani","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeirao Preto 14049-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,31]]},"reference":[{"key":"ref_1","first-page":"3922","article-title":"Autonomic impairment in patients with migraine","volume":"19","author":"Matei","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s10194-016-0645-6","article-title":"Autonomous control of cardiovascular reactivity in patients with episodic and chronic forms of migraine","volume":"17","author":"Mamontov","year":"2016","journal-title":"J. Headache Pain"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11916-018-0671-y","article-title":"Migraine and Autonomic Dysfunction: Which Is the Horse and Which Is the Jockey?","volume":"22","author":"Miglis","year":"2018","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.biopsycho.2005.11.013","article-title":"The role of vagal function in the risk for cardiovascular disease and mortality","volume":"74","author":"Thayer","year":"2007","journal-title":"Biol. Psychol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/0333102415583989","article-title":"Vagally mediated heart rate variability in headache patients\u2014A systematic review and meta-analysis","volume":"36","author":"Koenig","year":"2016","journal-title":"Cephalalgia"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/AJP.0000000000000242","article-title":"Chronic pain and heart rate variability in a cross-sectional occupational sample evidence for impaired vagal control","volume":"32","author":"Koenig","year":"2016","journal-title":"Clin. J. Pain"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jelectrocard.2019.05.018","article-title":"Electrographic indices in migraine patients: A systematic review and meta-analysis","volume":"57","author":"Lee","year":"2019","journal-title":"J. Electrocardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"647092","DOI":"10.3389\/fneur.2021.647092","article-title":"Heart Rate Variability Analysis in Episodic Migraine: A Cross-Sectional Study","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1600-0404.2009.01173.x","article-title":"Increased baroreflex sensitivity and heart rate variability in migraine patients","volume":"120","author":"Nilsen","year":"2009","journal-title":"Acta Neurol. Scand."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1542-474X.2008.00219.x","article-title":"Baroreflex sensitivity: Measurement and clinical implications","volume":"13","author":"Pinna","year":"2008","journal-title":"Ann. Noninvasive Electrocardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"320","DOI":"10.14336\/AD.2013.0400320","article-title":"Autonomic cardiovascular damage during post-menopause: The role of physical training","volume":"4","author":"Souza","year":"2013","journal-title":"Aging Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/01.jcp.0000177547.28961.03","article-title":"Effects of paroxetine and venlafaxine XR on heart rate variability in depression","volume":"25","author":"Davidson","year":"2005","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1111\/j.1526-4637.2012.01492.x","article-title":"Cross-Cultural Adaptation and Validation of the Brazilian Portuguese Version of the Pain Catastrophizing Scale","volume":"13","author":"Sehn","year":"2012","journal-title":"Pain Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.2147\/JPR.S131479","article-title":"The central sensitization inventory validated and adapted for a Brazilian population: Psychometric properties and its relationship with brain-derived neurotrophic factor","volume":"10","author":"Caumo","year":"2017","journal-title":"J. Pain Res."},{"key":"ref_15","first-page":"389","article-title":"Valida\u00e7\u00e3o da vers\u00e3o Brasileira em Portugu\u00eas do Invent\u00e1rio de Depress\u00e3o de Beck-II numa amostra da comunidade","volume":"34","author":"Gorenstein","year":"2012","journal-title":"Rev. Bras. Psiquiatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1590\/S1516-31802002000400006","article-title":"MIDAS (Migraine Disability Assessment): A valuable tool for work-site identification of migraine in workers in Brazil","volume":"120","author":"Fragoso","year":"2002","journal-title":"Sao Paulo Med. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1590\/S0004-282X2012001100006","article-title":"12 item allodynia symptom checklist\/brasil: Adapta\u00e7\u00e3o transcultural, consist\u00eancia interna e reprodutibilidade","volume":"70","author":"Florencio","year":"2012","journal-title":"Arq. Neuropsiquiatr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.exger.2012.11.009","article-title":"Aerobic physical training has little effect on cardiovascular autonomic control in aging rats subjected to early menopause","volume":"48","author":"Tezini","year":"2013","journal-title":"Exp. Gerontol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fnins.2019.00017","article-title":"Revisiting the sequence method for baroreflex analysis","volume":"13","author":"Silva","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1161\/01.CIR.90.4.1826","article-title":"Power spectrum analysis of heart rate variability to assess the changes in sympathovagal balance during graded orthostatic tilt","volume":"90","author":"Montano","year":"1994","journal-title":"Circulation"},{"key":"ref_21","first-page":"313","article-title":"A new method for evaluating the baroreflex role by a joint pattern Analysis of pulse interval and systolic blood pressure series","volume":"23","author":"Mancia","year":"1985","journal-title":"Med. Biol. Eng. Comput."},{"key":"ref_22","unstructured":"Cohen, J. (1988). Statistical Power Analysis for the Behavioral Sciences, Lawrence Erlbaum Associates. [2nd ed.]."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s10194-021-01222-w","article-title":"Shift from high-frequency to low-frequency episodic migraine in patients treated with Galcanezumab: Results from two global randomized clinical trials","volume":"22","author":"Jedynak","year":"2021","journal-title":"J. Headache Pain."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1590\/S0102-76382009000200018","article-title":"No\u00e7\u00f5es b\u00e1sicas da variabilidade da FC e sua aplicabilidade cl\u00ednica","volume":"24","author":"Vanderlei","year":"2009","journal-title":"Rev. Bras. Cir. Cardiovasc."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Task Force of the European Society of Cardiology the North American Society (1996). Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use. Circulation, 93, 1043\u20131065.","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0014-2999(85)90616-8","article-title":"Circulating CGRP Comes from the Perivascular Nerves","volume":"117","author":"Zaidi","year":"1985","journal-title":"Eur. J. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1749-6632.1992.tb22762.x","article-title":"Calcitonin Gene-Related Peptide in the Brain, Spinal Cord, and Some Peripheral Systems","volume":"657","author":"Arvidsson","year":"1992","journal-title":"Ann. NY Acad. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jash.2014.03.001","article-title":"Calcitonin gene-related peptide (CGRP) in autonomic cardiovascular regulation and vascular structure","volume":"8","author":"Mai","year":"2014","journal-title":"J. Am. Soc. Hypertens."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s10194-021-01281-z","article-title":"Comorbidities of primary headache disorders: A literature review with meta-analysis","volume":"22","author":"Caponnetto","year":"2021","journal-title":"J. Headache Pain"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Martelletti, P. (2022). Migraine in Medicine: A Machine-Generated Overview of Current Research, Springer.","DOI":"10.1007\/978-3-030-97359-9"},{"key":"ref_31","first-page":"7","article-title":"Meta-analytic evidence for decreased heart rate variability in chronic pain implicating parasympathetic nervous system dysregulation","volume":"157","author":"Giummarra","year":"2015","journal-title":"Pain"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/1\/763\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:49:07Z","timestamp":1760147347000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/1\/763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,31]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["ijerph20010763"],"URL":"https:\/\/doi.org\/10.3390\/ijerph20010763","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,31]]}}}