{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:51:16Z","timestamp":1790776276316,"version":"4.1.0"},"reference-count":26,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF)","award":["02NUK050A"],"award-info":[{"award-number":["02NUK050A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Radon, a naturally occurring radioactive noble gas, contributes significantly to lung cancer when incorporated from our natural environment. However, despite having unknown underlying mechanisms, radon is also used for therapeutic purposes to treat inflammatory diseases such as rheumatoid arthritis. Data on the distribution and accumulation of radon in different tissues represent an important factor in dose determination for risk estimation, the explanation of potential therapeutic effects and the calculation of doses to different tissues using biokinetic dosimetry models. In this paper, radon\u2019s solubility in bones, muscle tissue, adipose tissue, bone marrow, blood, a dissolved gelatin and oleic acid were determined. In analogy to current radon use in therapies, samples were exposed to radon gas for 1 h using two exposure protocols combined with established \u03b3-spectroscopic measurements. Solubility data varied over two orders of magnitude, with the lowest values from the dissolved gelatin and muscle tissue; radon\u2019s solubility in flat bones, blood and adipose tissue was one order of magnitude higher. The highest values for radon solubility were measured in bone marrow and oleic acid. The data for long bones as well as bone marrow varied significantly. The radon solubility in the blood suggested a radon distribution within the body that occurred via blood flow, reaching organs and tissues that were not in direct contact with radon gas during therapy. Tissues with similar compositions were expected to reveal similar radon solubilities; however, yellow bone marrow and adipose tissue showed differences in solubility even though their chemical composition is nearly the same\u2014indicating that interactions on the microscopic scale between radon and the solvent might be important. We found high solubility in bone marrow\u2014where sensitive hematopoietic cells are located\u2014and in adipose tissue, where the biological impact needs to be further elucidated.<\/jats:p>","DOI":"10.3390\/ijerph20031773","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T02:04:35Z","timestamp":1674093875000},"page":"1773","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Radon Solubility in Different Tissues after Short Term Exposure"],"prefix":"10.3390","volume":"20","author":[{"given":"Annika","family":"Hinrichs","sequence":"first","affiliation":[{"name":"GSI Helmholtzzentrum f\u00fcr Schwerionenforschung GmbH, 64291 Darmstadt, Germany"},{"name":"Physics Department, Goethe University Frankfurt am Main, 60438 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Schmitt","sequence":"additional","affiliation":[{"name":"GSI Helmholtzzentrum f\u00fcr Schwerionenforschung GmbH, 64291 Darmstadt, Germany"},{"name":"Physics Department, Goethe University Frankfurt am Main, 60438 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Papenfu\u00df","sequence":"additional","affiliation":[{"name":"GSI Helmholtzzentrum f\u00fcr Schwerionenforschung GmbH, 64291 Darmstadt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Roth","sequence":"additional","affiliation":[{"name":"GSI Helmholtzzentrum f\u00fcr Schwerionenforschung GmbH, 64291 Darmstadt, Germany"},{"name":"Chemistry and Biotechnology Department, University of Applied Science, 64295 Darmstadt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Fournier","sequence":"additional","affiliation":[{"name":"GSI Helmholtzzentrum f\u00fcr Schwerionenforschung GmbH, 64291 Darmstadt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Kraft","sequence":"additional","affiliation":[{"name":"GSI Helmholtzzentrum f\u00fcr Schwerionenforschung GmbH, 64291 Darmstadt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1309-5435","authenticated-orcid":false,"given":"Andreas","family":"Maier","sequence":"additional","affiliation":[{"name":"GSI Helmholtzzentrum f\u00fcr Schwerionenforschung GmbH, 64291 Darmstadt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"ICRP (2017). 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