{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:32:08Z","timestamp":1775856728703,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Ranula is a rare and benign extravasation mucocele that is clinically characterized by asymptomatic sublingual or submandibular masses. Surgical excision is considered the most effective treatment approach, but it has been associated with high invasiveness and several complications (hemorrhage, damage to Wharton\u2019s duct, and lingual nerve injury). Over the past decade, more conservative therapies have been rapidly disseminated into clinical practice to seek a more effective and less traumatic approach for young patients. In this report, an 8-year-old female with an asymptomatic, recurrent sublingual ranula was treated using a conservative approach with marsupialization and an intracystic injection of a plaque remover (Hybenx\u00ae gel). After incision of the cystic dome, Hybenx\u00ae gel was applied into the cystic lumen for 20 seconds and then aspirated; next, the area was rinsed thoroughly with sterile saline solution before suturing. Ultrasound re-evaluation at 10 months and intraoral clinical examination at 24 months confirmed the absence of relapse. Our results support the hypothesis that marsupialization combined with intracystic injection of Hybenx\u00ae gel could be an encouraging conservative treatment alternative for recurrent sublingual ranula in children. Further randomized controlled trials are needed to test this hypothesis.<\/jats:p>","DOI":"10.3390\/ijerph20032398","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T04:31:27Z","timestamp":1675053087000},"page":"2398","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["New Conservative Approach for the Management of Recurrent Sublingual Ranula\u2014A Case Report"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7287-7563","authenticated-orcid":false,"given":"Antonino","family":"Fiorino","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Reproductive and Odontostomatological Sciences, \u201cFederico II\u201d University of Naples, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1339-9172","authenticated-orcid":false,"given":"Edoardo","family":"Staderini","sequence":"additional","affiliation":[{"name":"Postgraduate School of Orthodontics, Universit\u00e0 Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalba","family":"Diana","sequence":"additional","affiliation":[{"name":"Postgraduate School of Orthodontics, Universit\u00e0 Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1127-0877","authenticated-orcid":false,"given":"Carlo","family":"Rengo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Salerno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Gallenzi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Reproductive and Odontostomatological Sciences, \u201cFederico II\u201d University of Naples, 80131 Naples, Italy"},{"name":"UOC Odontoiatria Generale e Ortodonzia, Dipartimento di Testa-Collo e Organi di Senso, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.tripleo.2004.01.013","article-title":"Clinical review of 580 ranulas","volume":"98","author":"Zhao","year":"2004","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/MOO.0000000000000103","article-title":"What is new in management of pediatric ranula?","volume":"22","author":"Zhi","year":"2014","journal-title":"Curr. Opin. Otolaryngol. 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