{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:44:03Z","timestamp":1765889043414,"version":"build-2065373602"},"reference-count":93,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan","award":["BR10965164","#SSH2020028"],"award-info":[{"award-number":["BR10965164","#SSH2020028"]}]},{"name":"Nazarbayev University","award":["BR10965164","#SSH2020028"],"award-info":[{"award-number":["BR10965164","#SSH2020028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background. Long COVID-19 symptoms appeared in many COVID-19 survivors. However, the prevalence and symptoms associated with long COVID-19 and its comorbidities have not been established. Methods. In total, 312 patients with long COVID-19 from 21 primary care centers were included in the study. At the six-month follow-up, their lung function was assessed by computerized tomography (CT) and spirometry, whereas cardiac function was assessed by electrocardiogram, Holter ECG, echocardiography, 24 h blood pressure monitoring, and a six-minute walk test (6MWT). Results. Of the 312 persons investigated, significantly higher systolic and diastolic blood pressure, left ventricular hypertrophy, and elevated NT-proBNP were revealed in participants with hypertension or type 2 diabetes. Left ventricular diastolic dysfunction was more frequently present in patients with hypertension. The most common registered CT abnormalities were fibrotic changes (83, 36.6%) and mediastinal lymphadenopathy (23, 10.1%). Among the tested biochemical parameters, three associations were found in long COVID-19 patients with hypertension but not diabetes: increased hemoglobin, fibrinogen, and ferritin. Nine patients had persisting IgM antibodies to SARS-CoV-2. Conclusions. We demonstrated a strong association between signs of cardiac dysfunction and lung fibrotic changes with comorbidities in a cohort of long COVID-19 subjects.<\/jats:p>","DOI":"10.3390\/ijerph20032567","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T02:29:03Z","timestamp":1675218543000},"page":"2567","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Lung Fibrotic Changes and Cardiological Dysfunction with Comorbidities in Long COVID-19 Cohort"],"prefix":"10.3390","volume":"20","author":[{"given":"Ainur","family":"Tauekelova","sequence":"first","affiliation":[{"name":"National Research Center for Cardiac Surgery, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanar","family":"Kalila","sequence":"additional","affiliation":[{"name":"National Research Center for Cardiac Surgery, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akerke","family":"Bakhtiyar","sequence":"additional","affiliation":[{"name":"National Research Center for Cardiac Surgery, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarina","family":"Sautbayeva","sequence":"additional","affiliation":[{"name":"School of Sciences and Humanities, Nazarbayev University, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polina","family":"Len","sequence":"additional","affiliation":[{"name":"School of Sciences and Humanities, Nazarbayev University, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliya","family":"Sailybayeva","sequence":"additional","affiliation":[{"name":"National Research Center for Cardiac Surgery, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadyk","family":"Khamitov","sequence":"additional","affiliation":[{"name":"National Research Center for Cardiac Surgery, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4309-0432","authenticated-orcid":false,"given":"Nazira","family":"Kadroldinova","sequence":"additional","affiliation":[{"name":"School of Medicine, Nazarbayev University, Astana 020000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Barteneva","sequence":"additional","affiliation":[{"name":"School of Sciences and Humanities, Nazarbayev University, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makhabbat","family":"Bekbossynova","sequence":"additional","affiliation":[{"name":"National Research Center for Cardiac Surgery, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e201595","DOI":"10.3201\/eid2607.201595","article-title":"Evidence supporting transmission of severe acute respiratory syndrome coronavirus 2 while pre-symptomatic or asymptomatic","volume":"26","author":"Furukawa","year":"2020","journal-title":"Emerg. 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