{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:43:58Z","timestamp":1787067838430,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81500190"],"award-info":[{"award-number":["81500190"]}]},{"name":"National Natural Science Foundation of China","award":["SHDC12019X20"],"award-info":[{"award-number":["SHDC12019X20"]}]},{"name":"National Natural Science Foundation of China","award":["2020YJZX0124"],"award-info":[{"award-number":["2020YJZX0124"]}]},{"name":"Clinical Science and Shanghai municipal hospital new frontier technology joint project","award":["81500190"],"award-info":[{"award-number":["81500190"]}]},{"name":"Clinical Science and Shanghai municipal hospital new frontier technology joint project","award":["SHDC12019X20"],"award-info":[{"award-number":["SHDC12019X20"]}]},{"name":"Clinical Science and Shanghai municipal hospital new frontier technology joint project","award":["2020YJZX0124"],"award-info":[{"award-number":["2020YJZX0124"]}]},{"name":"Shanghai Municipal Commission of Health and Family Planning","award":["81500190"],"award-info":[{"award-number":["81500190"]}]},{"name":"Shanghai Municipal Commission of Health and Family Planning","award":["SHDC12019X20"],"award-info":[{"award-number":["SHDC12019X20"]}]},{"name":"Shanghai Municipal Commission of Health and Family Planning","award":["2020YJZX0124"],"award-info":[{"award-number":["2020YJZX0124"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Objective: The aim of this study was to evaluate the predictive value of carotid-femoral pulse wave velocity (cfPWV) and cardiovascular disease in the hypertensive population in China and to determine the specific cfPWV cut-off value for assessing future cardiovascular disease (CVD) risk. Methods: This cross-sectional study included 630 hospital patients with primary hypertension and multiple cardiovascular risk factors or complications involving damage to clinical target organs. The study was conducted between July 2007 and October 2008. Atherosclerotic cardiovascular disease (ASCVD) risk calculations were computed according to criteria presented by the American College of Cardiology and the American Heart Association. Patients were stratified by a predefined risk threshold of 10% and divided into two groups: ASCVD \u2265 10% or ASCVD &lt; 10%. cfPWV was used as a marker of arterial stiffness. A receiver operating characteristics (ROC) curve was applied to establish the optimal cfPWV cut-off point to differentiate between participants with and without ASCVD risk. Results: In the study cohort of 630 patients (age 63.55.2 \u00b1 8.6 years, 61.7% male) with primary hypertension, the pressure indices (augmented pressure, augmentation index [AIx], aortic pulse pressure, aortic systolic pressure [SBP]) and Framingham Risk Scores (FRS) were greater in females than in males (p &lt; 0.001); ASCVD risk scores and peripheral diastolic pressure (DBP) were higher in males (p &lt; 0.05). All hemodynamic indices showed a significant positive correlation with ASCVD risk scores and FRS; AIx was not correlated with ASCVD risk scores. In multivariate logistic analysis, cfPWV was significantly associated with ASCVD risk (OR: 1.324, 95% confidence interval: 1.119\u20131.565, p &lt; 0.001) after adjusting for age, gender, smoking, body mass index, total cholesterol, fasting blood glucose, antihypertensive treatment, statin treatment, and DBP. In the ROC analysis, the area under the curve was 0.758 and 0.672 for cfPWV and aortic SBP (p &lt; 0.001 and p &lt; 0.001, respectively); the optimal critical value of cfPWV and aortic SBP was 12.45 m\/s (sensitivity 63.2%, specificity 77.8%) and 124.5 mmHg (sensitivity 63.9%, specificity 65.3%). Conclusions: cfPWV is significantly correlated with the risk of ASCVD. The best cut-off value of cfPWV for assessing future CVD risk in the hypertensive population in China is 12.45 m\/s.<\/jats:p>","DOI":"10.3390\/ijerph20042832","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T02:57:32Z","timestamp":1675652252000},"page":"2832","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Arterial Stiffness as a Predictor of the Index of Atherosclerotic Cardiovascular Disease in Hypertensive Patients"],"prefix":"10.3390","volume":"20","author":[{"given":"Guili","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Shanghai Institute of Hypertension, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueliang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shanghai Institute of Hypertension, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoli","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shanghai Institute of Hypertension, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8311-2010","authenticated-orcid":false,"given":"Alberto","family":"Avolio","sequence":"additional","affiliation":[{"name":"Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9850-405X","authenticated-orcid":false,"given":"Junli","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China"},{"name":"Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"China cardiovascular diseases report 2018: An updated summary","volume":"17","author":"Ma","year":"2020","journal-title":"J. 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