{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:50:44Z","timestamp":1781808644755,"version":"3.54.5"},"reference-count":41,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Affairs Bureau, the Ministry of Defense of Taiwan","award":["MND-MAB-D-111-075"],"award-info":[{"award-number":["MND-MAB-D-111-075"]}]},{"name":"Medical Affairs Bureau, the Ministry of Defense of Taiwan","award":["TSGH-B-109-010"],"award-info":[{"award-number":["TSGH-B-109-010"]}]},{"name":"Medical Affairs Bureau, the Ministry of Defense of Taiwan","award":["TSGH-E-110240"],"award-info":[{"award-number":["TSGH-E-110240"]}]},{"name":"Medical Affairs Bureau, the Ministry of Defense of Taiwan","award":["TSGH-B-111-018"],"award-info":[{"award-number":["TSGH-B-111-018"]}]},{"name":"Medical Affairs Bureau, the Ministry of Defense of Taiwan","award":["TSGH-D-111-121"],"award-info":[{"award-number":["TSGH-D-111-121"]}]},{"name":"Medical Affairs Bureau, the Ministry of Defense of Taiwan","award":["TYAFGH-A-110-020"],"award-info":[{"award-number":["TYAFGH-A-110-020"]}]},{"name":"Tri-Service General Hospital Research Foundation","award":["MND-MAB-D-111-075"],"award-info":[{"award-number":["MND-MAB-D-111-075"]}]},{"name":"Tri-Service General Hospital Research Foundation","award":["TSGH-B-109-010"],"award-info":[{"award-number":["TSGH-B-109-010"]}]},{"name":"Tri-Service General Hospital Research Foundation","award":["TSGH-E-110240"],"award-info":[{"award-number":["TSGH-E-110240"]}]},{"name":"Tri-Service General Hospital Research Foundation","award":["TSGH-B-111-018"],"award-info":[{"award-number":["TSGH-B-111-018"]}]},{"name":"Tri-Service General Hospital Research Foundation","award":["TSGH-D-111-121"],"award-info":[{"award-number":["TSGH-D-111-121"]}]},{"name":"Tri-Service General Hospital Research Foundation","award":["TYAFGH-A-110-020"],"award-info":[{"award-number":["TYAFGH-A-110-020"]}]},{"name":"Taoyuan Armed Forces General Hospital","award":["MND-MAB-D-111-075"],"award-info":[{"award-number":["MND-MAB-D-111-075"]}]},{"name":"Taoyuan Armed Forces General Hospital","award":["TSGH-B-109-010"],"award-info":[{"award-number":["TSGH-B-109-010"]}]},{"name":"Taoyuan Armed Forces General Hospital","award":["TSGH-E-110240"],"award-info":[{"award-number":["TSGH-E-110240"]}]},{"name":"Taoyuan Armed Forces General Hospital","award":["TSGH-B-111-018"],"award-info":[{"award-number":["TSGH-B-111-018"]}]},{"name":"Taoyuan Armed Forces General Hospital","award":["TSGH-D-111-121"],"award-info":[{"award-number":["TSGH-D-111-121"]}]},{"name":"Taoyuan Armed Forces General Hospital","award":["TYAFGH-A-110-020"],"award-info":[{"award-number":["TYAFGH-A-110-020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>We aim to explore if there is a relationship between acute mountain sickness (AMS) and the risk of psychiatric disorders in Taiwan by using the National Health Insurance Research Database for to the rare studies on this topic. We enrolled 127 patients with AMS, and 1270 controls matched for sex, age, monthly insured premiums, comorbidities, seasons for medical help, residences, urbanization level, levels of care, and index dates were chosen from 1 January 2000 to 31 December 2015. There were 49 patients with AMS and 140 controls developed psychiatric disorders within the 16-year follow-up. The Fine\u2013Gray model analyzed that the patients with AMS were prone to have a greater risk for the development of psychiatric disorders with an adjusted sub-distribution hazard ratio (sHRs) of 10.384 (95% confidence interval [CI]: 7.267\u201314.838, p &lt; 0.001) for psychiatric disorders. The AMS group was associated with anxiety disorders, depressive disorders, bipolar disorder, sleep disorders, posttraumatic stress disorder\/acute stress disorder, psychotic disorder, and substance-related disorder (SRD). The relationship between anxiety, depression, sleep disorders, SRD, and AMS still persisted even after we excluded the psychiatric disorders within the first five years after AMS. There was an association between AMS and the rising risk of psychiatric disorders in the 16 years of long-term follow-up research.<\/jats:p>","DOI":"10.3390\/ijerph20042868","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T01:56:48Z","timestamp":1675735008000},"page":"2868","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Acute Mountain Sickness and the Risk of Subsequent Psychiatric Disorders\u2014A Nationwide Cohort Study in Taiwan"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6555-8991","authenticated-orcid":false,"given":"Ya-Hsuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei City 11490, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3286-0780","authenticated-orcid":false,"given":"Wu-Chien","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan"},{"name":"School of Public Health, National Defense Medical Center, Taipei City 11490, Taiwan"},{"name":"Taiwanese Injury Prevention and Safety Promotion Association, Taipei City 11490, Taiwan"},{"name":"Graduate Institute of Life Sciences, National Defense Medical Center, Taipei City 11490, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4576-9900","authenticated-orcid":false,"given":"Chi-Hsiang","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan"},{"name":"School of Public Health, National Defense Medical Center, Taipei City 11490, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ning","family":"Her","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei City 11490, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yi","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei City 11490, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biing-Luen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Yonghe Cardinal Tien Hospital, New Taipei City 23148, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5019-0661","authenticated-orcid":false,"given":"Fang-Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei City 11490, Taiwan"},{"name":"Department of Medical Research, Tri-Service General Hospital, Beitou Branch, National Defense Medical Center, Taipei City 11243, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Jung","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei City 11490, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5881-7089","authenticated-orcid":false,"given":"Nian-Sheng","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei City 11490, Taiwan"},{"name":"Student Counseling Center, National Defense Medical Center, Taipei City 11490, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"ref_1","first-page":"499","article-title":"High altitude illness and related diseases\u2014A review","volume":"105","author":"Gudbjartsson","year":"2019","journal-title":"Laeknabladid"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1001\/jama.2017.16192","article-title":"Does This Patient Have Acute Mountain Sickness? 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