{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:10:43Z","timestamp":1769602243580,"version":"3.49.0"},"reference-count":29,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Parkinson\u2019s Disease (PD) affects the cardiorespiratory system, causing an increase in the left ventricular mass in the heart and respiratory muscle weakness in relation to healthy individuals. The objective of this study was to investigate the effects of progressive resistive physical exercise on the vertical ladder on the histomorphometry of cardiac tissue and respiratory muscles in rats with PD. Seventy male Wistar rats, aged 40 days old, were divided into Parkinson\u2019s (PD) and Sham (SH) groups; they were also subdivided into groups that performed progressive resistive physical exercise on the vertical ladder Before Surgery (ExBS), After Surgery (ExAS), and Before and After Surgery (ExBAS). The physical training was carried out before and\/or after PD induction. Exercise was performed five times a week for 25 min\/day for four or eight weeks. PD induction was conducted via electrolytic stimulation of the Substantia nigra of the animals\u2019 brains, adopting the following stereotaxic table coordinates: \u22124.9; lateral medium equal to 1.7, and dorsoventral equal to 8.1. For the morphometric analysis of the heart, the following variables were calculated: relative weight and diameter and thickness of the left ventricle. The diaphragm and the myocardial, intercostal, and abdominal muscles were stained with Hematoxylin and Eosin (HE). The histomorphometric analysis was performed using the ImageJ software to assess the cross-sectional area of muscles and the number of muscle fibers. Progressive resistance exercise promoted the hypertrophy of respiratory muscles and the left ventricle in animals with PD.<\/jats:p>","DOI":"10.3390\/ijerph20042925","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T02:29:08Z","timestamp":1675823348000},"page":"2925","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Effects of Resistance Exercise on the Cardiorespiratory Tissue of Rats with Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"20","author":[{"given":"Graziele Mayra Santos","family":"Moreira","sequence":"first","affiliation":[{"name":"Graduate Program in Morphofunctional Sciences (PPGCM), Federal University of S\u00e3o Jo\u00e3o del-Rei (UFSJ), Sao Joao del Rei 36307-352, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7370-8892","authenticated-orcid":false,"given":"Laila Cristina Moreira","family":"Dam\u00e1zio","sequence":"additional","affiliation":[{"name":"Graduate Program in Morphofunctional Sciences (PPGCM), Federal University of S\u00e3o Jo\u00e3o del-Rei (UFSJ), Sao Joao del Rei 36307-352, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana Ven\u00e2ncio da","family":"Silva","sequence":"additional","affiliation":[{"name":"Graduate Program in Morphofunctional Sciences (PPGCM), Federal University of S\u00e3o Jo\u00e3o del-Rei (UFSJ), Sao Joao del Rei 36307-352, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto Targino","family":"Silveira","sequence":"additional","affiliation":[{"name":"Physiotherapy Department, Presidente Tancredo de Almeida Neves University Center (UNIPTAN\/Afya), S\u00e3o Jo\u00e3o del Rei 36307-251, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella Giordano","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana Aparecida de Sousa","family":"Silva","sequence":"additional","affiliation":[{"name":"Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luan Alves","family":"Pereira","sequence":"additional","affiliation":[{"name":"Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Clara Silva","family":"Costa","sequence":"additional","affiliation":[{"name":"Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-4501","authenticated-orcid":false,"given":"Ismael Augusto Lima","family":"Santos","sequence":"additional","affiliation":[{"name":"Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eduarda Paiva","family":"Campos","sequence":"additional","affiliation":[{"name":"Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luna Sara Campos","family":"Vaz","sequence":"additional","affiliation":[{"name":"Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zenaide Alves","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Victor Ribeiro Silva","family":"Gomes","sequence":"additional","affiliation":[{"name":"Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Henrique Almeida Campos","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Graduate Program in Morphofunctional Sciences (PPGCM), Federal University of S\u00e3o Jo\u00e3o del-Rei (UFSJ), Sao Joao del Rei 36307-352, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliam Midori","family":"Ide","sequence":"additional","affiliation":[{"name":"Graduate Program in Morphofunctional Sciences (PPGCM), Federal University of S\u00e3o Jo\u00e3o del-Rei (UFSJ), Sao Joao del Rei 36307-352, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"ref_1","first-page":"62","article-title":"Patients\u2019 experience with Parkinson\u2019s disease","volume":"20","author":"Alvarez","year":"2007","journal-title":"Acta Paul. 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