{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:33:34Z","timestamp":1780104814936,"version":"3.54.0"},"reference-count":33,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Periodontal diseases are one of the main causes of tooth loss and the second most common oral disease after carries. Patients with autoimmune diseases, such as Hashimoto\u2019s disease, are more often vulnerable to infection. In the study group of patients, despite the lack of other signs of gingivitis, bleeding occurred after tooth brushing or minor trauma. Bleeding on probing is the first objective sign of ongoing inflammation. The study was conducted on a group of 17 patients diagnosed with Hashimoto\u2019s disease. The atelocollagen Linerase (100 mg) thinned with 5 mL 0.9% NaCl was used. A total of 0.05 mL of solution was injected into keratinized gingiva, two millimeters above the gingival papillae basement, four times in two-week intervals. The greatest decrease in the number of bleeding points was observed after the first and second injections of atelocollagen. After the third and fourth injections, the average BOP continued to decrease, but the decline was very slow. The use of atelocollagen made it possible to eliminate bleeding symptoms in the study group.<\/jats:p>","DOI":"10.3390\/ijerph20042954","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T04:21:59Z","timestamp":1675830119000},"page":"2954","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reduction in Gingival Bleeding after Atelocollagen Injection in Patients with Hashimoto\u2019s Disease\u2014A Pilot Study"],"prefix":"10.3390","volume":"20","author":[{"given":"Sylwia","family":"Klewin-Steinb\u00f6ck","sequence":"first","affiliation":[{"name":"Department of Dental Surgery, Periodontal and Oral Mucosa Diseases, Poznan University of Medical Science, 70, Bukowska St., 60-812 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"Wyganowska","sequence":"additional","affiliation":[{"name":"Department of Dental Surgery, Periodontal and Oral Mucosa Diseases, Poznan University of Medical Science, 70, Bukowska St., 60-812 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"22127","DOI":"10.1038\/s41598-021-01682-9","article-title":"Implication of thyroid function in periodontitis: A nationwide population-based study","volume":"11","author":"Song","year":"2021","journal-title":"Sci. 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