{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:48:39Z","timestamp":1791258519838,"version":"4.1.0"},"reference-count":56,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:00:00Z","timestamp":1676678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Ministry of Science and Higher Education","award":["No: MN\/WF\/2018\/2"],"award-info":[{"award-number":["No: MN\/WF\/2018\/2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Memory impairment, reduced learning ability, decreased concentration, and psychomotor performance can be all signs of deleterious impact of hypoxia on cognitive functioning. In turn, physical exercise can improve performance and enhance cognitive functions. The purpose of this study was to investigate whether the potential positive effects of exercise performed under normobaric hypoxia can counteract the negative effects of hypoxia on cognitive function, and whether these changes correlate with brain-derived neurotrophic factor (BDNF) concentrations. Seventeen healthy subjects participated in a crossover study where they performed two sessions of single breathing bouts combined with moderate intensity exercise under two conditions: normoxia (NOR EX) and normobaric hypoxia (NH EX). To assess cognitive function, Stroop test was applied. There were no significant differences in any part of the Stroop interference test regardless of the conditions (NOR, NH), despite a statistical decrease in SpO2 (p &lt; 0.0001) under normobaric hypoxic conditions. In addition, a statistical increase (p &lt; 0.0001) in BDNF concentration was observed after both conditions. Acute exercise under normobaric hypoxia did not impair cognitive function despite a significant decrease in SpO2. Exercise in such conditions may offset the negative effects of hypoxia alone on cognitive function. This may be related to the significant increase in BDNF concentration and, as a consequence, positively affect the executive functions.<\/jats:p>","DOI":"10.3390\/ijerph20043629","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T03:29:06Z","timestamp":1676863746000},"page":"3629","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exercise-Induced Elevated BDNF Concentration Seems to Prevent Cognitive Impairment after Acute Exposure to Moderate Normobaric Hypoxia among Young Men"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8491-4525","authenticated-orcid":false,"given":"Maciej","family":"Chroboczek","sequence":"first","affiliation":[{"name":"Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5520-1748","authenticated-orcid":false,"given":"Sylwester","family":"Kujach","sequence":"additional","affiliation":[{"name":"Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"\u0141uszczyk","sequence":"additional","affiliation":[{"name":"Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Soya","sequence":"additional","affiliation":[{"name":"Sports Neuroscience Division, Advanced Research Initiative for Human High Performance, Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8574, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rados\u0142aw","family":"Laskowski","sequence":"additional","affiliation":[{"name":"Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland"},{"name":"Laboratory of Exercise Biochemistry and Neuroendocrinology, Department of Sports Neuroscience, Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sports Sciences, University of Tsukuba, Tsukuba 305-8574, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,18]]},"reference":[{"key":"ref_1","first-page":"405","article-title":"Multiple choice reaction time and movement time during physical exertion","volume":"42","author":"Levitt","year":"1971","journal-title":"Res. 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