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We studied fecal viromes of twenty-six bats captured in 2015 in the Moscow Region and found 13 of 26 (50%) samples to be coronavirus positive. Of P. nathusii (the Nathusius\u2019 pipistrelle), 3 of 6 samples were carriers of a novel MERS-related betacoronavirus. We sequenced and assembled the complete genome of this betacoronavirus and named it MOW-BatCoV strain 15-22. Whole genome phylogenetic analysis suggests that MOW-BatCoV\/15-22 falls into a distinct subclade closely related to human and camel MERS-CoV. Unexpectedly, the phylogenetic analysis of the novel MOW-BatCoV\/15-22 spike gene showed the closest similarity to CoVs from Erinaceus europaeus (European hedgehog). We suppose MOW-BatCoV could have arisen as a result of recombination between ancestral viruses of bats and hedgehogs. Molecular docking analysis of MOW-BatCoV\/15-22 spike glycoprotein binding to DPP4 receptors of different mammals predicted the highest binding ability with DPP4 of the Myotis brandtii bat (docking score \u2212320.15) and the E. europaeus (docking score \u2013294.51). Hedgehogs are widely kept as pets and are commonly found in areas of human habitation. As this novel bat-CoV is likely capable of infecting hedgehogs, we suggest hedgehogs can act as intermediate hosts between bats and humans for other bat-CoVs.<\/jats:p>","DOI":"10.3390\/ijerph20043702","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T03:29:06Z","timestamp":1676863746000},"page":"3702","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Identification and Genetic Characterization of MERS-Related Coronavirus Isolated from Nathusius\u2019 Pipistrelle (Pipistrellus nathusii) near Zvenigorod (Moscow Region, Russia)"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6326-1249","authenticated-orcid":false,"given":"Anna S.","family":"Speranskaya","sequence":"first","affiliation":[{"name":"Scientific Research Institute for Systems Biology and Medicine, Federal Service on Consumers\u2019 Rights Protection and Human Well-Being Surveillance, 117246 Moscow, Russia"},{"name":"Central Research Institute for Epidemiology, Federal Service on Consumers\u2019 Rights Protection and Human Well-Being Surveillance, 111123 Moscow, Russia"},{"name":"Biological Department, Lomonosov Moscow State University, 119234 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4911-3677","authenticated-orcid":false,"given":"Ilia V.","family":"Artiushin","sequence":"additional","affiliation":[{"name":"Biological Department, Lomonosov Moscow State University, 119234 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-3164","authenticated-orcid":false,"given":"Andrei E.","family":"Samoilov","sequence":"additional","affiliation":[{"name":"Scientific Research Institute for Systems Biology and Medicine, Federal Service on Consumers\u2019 Rights Protection and Human Well-Being Surveillance, 117246 Moscow, Russia"},{"name":"Saint-Petersburg Pasteur Institute, Federal Service on Consumers\u2019 Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena V.","family":"Korneenko","sequence":"additional","affiliation":[{"name":"Scientific Research Institute for Systems Biology and Medicine, Federal Service on Consumers\u2019 Rights Protection and Human Well-Being Surveillance, 117246 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirill V.","family":"Khabudaev","sequence":"additional","affiliation":[{"name":"Scientific Research Institute for Systems Biology and Medicine, Federal Service on Consumers\u2019 Rights Protection and Human Well-Being Surveillance, 117246 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0130-5079","authenticated-orcid":false,"given":"Elena N.","family":"Ilina","sequence":"additional","affiliation":[{"name":"Scientific Research Institute for Systems Biology and Medicine, Federal Service on Consumers\u2019 Rights Protection and Human Well-Being Surveillance, 117246 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander P.","family":"Yusefovich","sequence":"additional","affiliation":[{"name":"Biological Department, Lomonosov Moscow State University, 119234 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina V.","family":"Safonova","sequence":"additional","affiliation":[{"name":"Department of Particularly Dangerous Diseases, Anti-Plague Center, Federal Service on Consumers\u2019 Rights Protection and Human Well-Being Surveillance, 127490 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-4872","authenticated-orcid":false,"given":"Anna 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Russia"},{"name":"Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov First Moscow State Medical University, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Daszak","sequence":"additional","affiliation":[{"name":"EcoHealth Alliance, New York, NY 10018, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,19]]},"reference":[{"key":"ref_1","unstructured":"WHO Team (2022). 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