{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:57:18Z","timestamp":1782921438065,"version":"3.54.5"},"reference-count":40,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["284910"],"award-info":[{"award-number":["284910"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>There is an increasing interest in developing natural herb-infused functional beverages with health benefits; therefore, in this study, we aimed to evaluate the effect of strawberry, blueberry, and strawberry-blueberry blend decoction-based functional beverages on obesity-related metabolic alterations in high-fat and high-fructose diet-fed rats. The administration of the three berry-based beverages for eighteen weeks prevented the development of hypertriglyceridemia in obese rats (1.29\u20131.78-fold) and hepatic triglyceride accumulation (1.38\u20131.61-fold), preventing the development of hepatic steatosis. Furthermore, all beverages significantly down-regulated Fasn hepatic expression, whereas the strawberry beverage showed the greatest down-regulation of Acaca, involved in fatty acid de novo synthesis. Moreover, the strawberry beverage showed the most significant up-regulation of hepatic Cpt1 and Acadm (fatty acid \u03b2-oxidation). In contrast, the blueberry beverage showed the most significant down-regulation of hepatic Fatp5 and Cd36 (fatty acid intracellular transport). Nevertheless, no beneficial effect was observed on biometric measurements, adipose tissue composition, and insulin resistance. On the other hand, several urolithins and their derivatives, and other urinary polyphenol metabolites were identified after the strawberry-based beverages supplementation. In contrast, enterolactone was found significantly increase after the intake of blueberry-based beverages. These results demonstrate that functional beverages elaborated with berry fruits prevent diet-induced hypertriglyceridemia and hepatic steatosis by modulating critical genes involved in fatty acid hepatic metabolism.<\/jats:p>","DOI":"10.3390\/ijerph20054418","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T03:06:43Z","timestamp":1677726403000},"page":"4418","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Strawberry, Blueberry, and Strawberry-Blueberry Blend Beverages Prevent Hepatic Steatosis in Obese Rats by Modulating Key Genes Involved in Lipid Metabolism"],"prefix":"10.3390","volume":"20","author":[{"given":"Ana Mar\u00eda","family":"Sotelo-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Chemistry School, Universidad Aut\u00f3noma de Quer\u00e9taro, Quer\u00e9taro 76010, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosal\u00eda","family":"Reynoso-Camacho","sequence":"additional","affiliation":[{"name":"Chemistry School, Universidad Aut\u00f3noma de Quer\u00e9taro, Quer\u00e9taro 76010, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Karina","family":"Hern\u00e1ndez-Calvillo","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica Multidisciplinaria Reynosa-Aztl\u00e1n, Universidad Aut\u00f3noma de Tamaulipas, Reynosa 88740, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paola","family":"Casta\u00f1\u00f3n-Serv\u00edn","sequence":"additional","affiliation":[{"name":"Chemistry School, Universidad Aut\u00f3noma de Quer\u00e9taro, Quer\u00e9taro 76010, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Gustavo","family":"Garc\u00eda-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Chemistry School, Universidad Aut\u00f3noma de Quer\u00e9taro, Quer\u00e9taro 76010, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2621-6603","authenticated-orcid":false,"given":"Haiku Daniel de Jes\u00fas","family":"G\u00f3mez-Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Chemistry School, Universidad Aut\u00f3noma de Quer\u00e9taro, Quer\u00e9taro 76010, Mexico"},{"name":"Facultad de Estudios Superiores Cuautil\u00e1n, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Quer\u00e9taro 76231, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Mart\u00ednez-Maldonado","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Gastronom\u00eda, Instituto Tecnol\u00f3gico Superior de Huichapan, Huichapan 42411, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ericka Alejandra","family":"de los R\u00edos","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology, Campus Juriquilla, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Quer\u00e9taro 76230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7606-0892","authenticated-orcid":false,"given":"Iza Fernanda","family":"P\u00e9rez-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Chemistry School, Universidad Aut\u00f3noma de Quer\u00e9taro, Quer\u00e9taro 76010, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"key":"ref_1","unstructured":"(2023, January 09). 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