{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:56:33Z","timestamp":1760147793023,"version":"build-2065373602"},"reference-count":60,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Myopia is one of the most common eye disorders involving abnormal focusing of light rays. The studies recognize the association between the stomatognathic and visual systems. This compound may have a neurological basis associated with disorders such as central sensitization. The main aim of this study was to evaluate the influence of central sensitization on the bioelectrical activity of selected muscles of the masticatory organ in subjects with myopia. Methods: Selected masticatory and cervical spine muscles were analyzed using an eight-channel BioEMG III electromyograph. Central sensitization was analyzed using the central sensitization inventory. Results: Statistical analysis revealed significantly higher scores on the central sensitization inventory in subjects with axial myopia compared to subjects without refractive error. Repeated positive correlations were observed in the sternocleidomastoid muscle activity and negative correlations in the digastric muscle activity during open and closed eyes in myopic subjects. Conclusions: Subjects with myopia have an increased score in the central sensitization inventory. The increase in the central sensitization inventory score is connected with the changes within the electromyographic activity of the masticatory and neck muscles. The effect of central sensitization on masticatory muscle activity in myopic subjects requires further study.<\/jats:p>","DOI":"10.3390\/ijerph20054524","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T03:22:05Z","timestamp":1678072925000},"page":"4524","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploratory Study on Central Sensitization and Bioelectrical Activity of the Selected Masticatory Muscles in Subjects with Myopia"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-0641","authenticated-orcid":false,"given":"Grzegorz","family":"Zieli\u0144ski","sequence":"first","affiliation":[{"name":"Department of Sports Medicine, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Matysik-Wo\u017aniak","sequence":"additional","affiliation":[{"name":"Department of General and Pediatric Ophthalmology, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Baszczowski","sequence":"additional","affiliation":[{"name":"Interdisciplinary Scientific Group of Sports Medicine, Department of Sports Medicine, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Rapa","sequence":"additional","affiliation":[{"name":"Students\u2019 Scientific Association at the Department and Clinic of General and Pediatric Ophthalmology, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0800-6103","authenticated-orcid":false,"given":"Micha\u0142","family":"Ginszt","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Physiotherapy, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Szkutnik","sequence":"additional","affiliation":[{"name":"Independent Unit of Functional Masticatory Disorders, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Rejdak","sequence":"additional","affiliation":[{"name":"Department of General and Pediatric Ophthalmology, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0265-9960","authenticated-orcid":false,"given":"Piotr","family":"Gawda","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuron.2007.07.016","article-title":"Nociceptors\u2014Noxious Stimulus Detectors","volume":"55","author":"Woolf","year":"2007","journal-title":"Neuron"},{"key":"ref_2","unstructured":"Armstrong, S.A., and Herr, M.J. (2022). StatPearls, StatPearls Publishing."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","article-title":"Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J. Pain"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e0020","DOI":"10.5041\/RMMJ.10204","article-title":"Central Sensitization Syndrome and the Initial Evaluation of a Patient with Fibromyalgia: A Review","volume":"6","author":"Fleming","year":"2015","journal-title":"Rambam Maimonides Med. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/AJP.0b013e31821c98ec","article-title":"Altered Central Sensitization in Subgroups of Women With Vulvodynia","volume":"27","author":"Zhang","year":"2011","journal-title":"Clin. J. Pain"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/306686a0","article-title":"Evidence for a central component of post-injury pain hypersensitivity","volume":"306","author":"Woolf","year":"1983","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1093\/brain\/5.4.492","article-title":"The Phenomena of Angina Pectoris, and their Bearing Upon the Theory of Counter-Irritation","volume":"5","author":"Sturge","year":"1883","journal-title":"Brain"},{"key":"ref_8","unstructured":"(2023, March 01). Terminology | International Association for the Study of Pain. Available online: https:\/\/www.iasp-pain.org\/resources\/terminology\/."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","article-title":"Neuronal Plasticity: Increasing the Gain in Pain","volume":"288","author":"Woolf","year":"2000","journal-title":"Science"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40945-020-00095-7","article-title":"Diagnostic accuracy of the clinical indicators to identify central sensitization pain in patients with musculoskeletal pain","volume":"11","author":"Bittencourt","year":"2021","journal-title":"Arch. Physiother."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.5114\/reum.2019.86422","article-title":"Translation and cross-cultural adaptation of the Polish Central Sensitization Inventory","volume":"57","author":"Turczyn","year":"2019","journal-title":"Rheumatology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/eye.2013.280","article-title":"Epidemiology of myopia","volume":"28","author":"Foster","year":"2014","journal-title":"Eye"},{"key":"ref_13","unstructured":"(2009). Medical Advisory Secretariat Phakic Intraocular Lenses for the Treatment of Refractive Errors: An Evidence-Based Analysis. Ont. Health Technol. Assess. Ser., 9, 1\u2013120."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41572-020-00231-4","article-title":"Myopia","volume":"6","author":"Baird","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_15","unstructured":"Lens, A., Nemeth, S.C., and Ledford, J.K. (2008). Ocular Anatomy and Physiology, SLACK. [2nd ed.]."},{"key":"ref_16","unstructured":"Grosvenor, T.P. (2007). Primary Care Optometry, Butterworth-Heinemann\/Elsevier. [5th ed.]."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"M20","DOI":"10.1167\/iovs.18-25957","article-title":"IMI\u2013Defining and Classifying Myopia: A Proposed Set of Standards for Clinical and Epidemiologic Studies","volume":"60","author":"Flitcroft","year":"2019","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/ICL.0000000000000499","article-title":"A Review of Current Concepts of the Etiology and Treatment of Myopia","volume":"44","author":"Cooper","year":"2018","journal-title":"Eye Contact Lens Sci. Clin. Pract."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"460","DOI":"10.2174\/1874210601610010460","article-title":"Dental Occlusion and Ophthalmology: A Literature Review","volume":"10","author":"Marchili","year":"2016","journal-title":"Open Dent. J."},{"key":"ref_20","first-page":"18","article-title":"Visual input effect on EMG activity of masticatory and postural muscles in healthy and in myopic children","volume":"7","author":"Monaco","year":"2006","journal-title":"Eur. J. Paediatr. Dent."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Zieli\u0144ski, G., Matysik-Wo\u017aniak, A., Rapa, M., Baszczowski, M., Ginszt, M., Zawadka, M., Szkutnik, J., Rejdak, R., and Gawda, P. (2021). The Influence of Visual Input on Electromyographic Patterns of Masticatory and Cervical Spine Muscles in Subjects with Myopia. J. Clin. Med., 10.","DOI":"10.3390\/jcm10225376"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Zieli\u0144ski, G., W\u00f3jcicki, M., Rapa, M., Matysik-Wo\u017aniak, A., Baszczowski, M., Ginszt, M., Litko-Rola, M., Szkutnik, J., R\u00f3\u017cy\u0142o-Kalinowska, I., and Rejdak, R. (2022). Masticatory Muscle Thickness and Activity Correlates to Eyeball Length, Intraocular Pressure, Retinal and Choroidal Thickness in Healthy Women versus Women with Myopia. J. Pers. Med., 12.","DOI":"10.3390\/jpm12040626"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zieli\u0144ski, G., Filipiak, Z., Ginszt, M., Matysik-Wo\u017aniak, A., Rejdak, R., and Gawda, P. (2022). The Organ of Vision and the Stomatognathic System\u2014Review of Association Studies and Evidence-Based Discussion. Brain Sci., 12.","DOI":"10.3390\/brainsci12010014"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9435","DOI":"10.1038\/s41598-022-13607-1","article-title":"Effects of visual input on changes in the bioelectrical activity of the cervical and masticatory muscles in myopic subjects","volume":"12","author":"Baszczowski","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/ICO.0000000000000033","article-title":"Is There a Relationship Between Pathologic Myopia and Dry Eye Syndrome?","volume":"33","author":"Ilhan","year":"2014","journal-title":"Cornea"},{"key":"ref_26","first-page":"746","article-title":"Burning Eye Syndrome: Do Neuropathic Pain Mechanisms Underlie Chronic Dry Eye?","volume":"17","author":"Kalangara","year":"2016","journal-title":"Pain Med. Off. J. Am. Acad. Pain Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.semarthrit.2014.11.002","article-title":"The role of central sensitization in shoulder pain: A systematic literature review","volume":"44","author":"Sanchis","year":"2015","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s11916-003-0062-9","article-title":"Central and peripheral sensitization in tension-type headache","volume":"7","author":"Bendtsen","year":"2003","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5957076","DOI":"10.1155\/2017\/5957076","article-title":"Central Sensitization-Based Classification for Temporomandibular Disorders: A Pathogenetic Hypothesis","volume":"2017","author":"Monaco","year":"2017","journal-title":"Pain Res. Manag."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"576","DOI":"10.5604\/00114553.1065048","article-title":"Research Diagnostic Criteria for Temporomandibular Disorders (RDC\/TMD)\u2014The Polish version of a dual-axis system for the diagnosis of TMD. RDC\/TMD Form","volume":"66","author":"Osiewicz","year":"2013","journal-title":"J. Stomatol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Zieli\u0144ski, G., Baszczowski, M., Ginszt, M., Rapa, M., Matysik-Wo\u017aniak, A., Szkutnik, J., Rejdak, R., and Gawda, P. (2022). Analysis of changes in electromyographic masticatory muscle activity in relation to the selected correction of refractive error. Ann. Agric. Environ. Med.","DOI":"10.26444\/aaem\/150412"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"750","DOI":"10.5604\/00114553.1074579","article-title":"Correlation between activity and asymmetry indices and skeletal classes in symptomatic-free young adults","volume":"66","author":"Wieczorek","year":"2013","journal-title":"J. Stomatol."},{"key":"ref_33","first-page":"e354017","article-title":"Relationship between Occlusal Force Distribution and the Activity of Masseter and Anterior Temporalis Muscles in Asymptomatic Young Adults","volume":"2013","author":"Wieczorek","year":"2012","journal-title":"BioMed Res. Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12903-015-0099-2","article-title":"Activity of the masticatory muscles and occlusal contacts in young adults with and without orthodontic treatment","volume":"15","author":"Wieczorek","year":"2015","journal-title":"BMC Oral Health"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S1050-6411(00)00027-4","article-title":"Development of recommendations for SEMG sensors and sensor placement procedures","volume":"10","author":"Hermens","year":"2000","journal-title":"J. Electromyogr. Kinesiol. Off. J. Int. Soc. Electrophysiol. Kinesiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0002-9394(82)90197-0","article-title":"New Visual Acuity Charts for Clinical Research","volume":"94","author":"Ferris","year":"1982","journal-title":"Am. J. Ophthalmol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1533-2500.2011.00493.x","article-title":"The Development and Psychometric Validation of the Central Sensitization Inventory (CSI)","volume":"12","author":"Mayer","year":"2012","journal-title":"Pain Pract."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jpain.2012.11.012","article-title":"The Central Sensitization Inventory (CSI): Establishing Clinically Significant Values for Identifying Central Sensitivity Syndromes in an Outpatient Chronic Pain Sample","volume":"14","author":"Neblett","year":"2013","journal-title":"J. Pain Off. J. Am. Pain Soc."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Kosi\u0144ska, B., Tarnacka, B., Turczyn, P., Gromadzka, G., Malec-Milewska, M., Janikowska-Ho\u0142owenko, D., and Neblett, R. (2021). Psychometric validation of the Polish version of the Central Sensitization Inventory in subjects with chronic spinal pain. BMC Neurol., 21.","DOI":"10.1186\/s12883-021-02510-3"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3389\/fpsyg.2013.00863","article-title":"Calculating and reporting effect sizes to facilitate cumulative science: A practical primer for t-tests and ANOVAs","volume":"4","author":"Lakens","year":"2013","journal-title":"Front. Psychol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1037\/a0024338","article-title":"Effect size estimates: Current use, calculations, and interpretation","volume":"141","author":"Fritz","year":"2012","journal-title":"J. Exp. Psychol. Gen."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Cohen, J. (2013). Statistical Power Analysis for the Behavioral Sciences, Routledge.","DOI":"10.4324\/9780203771587"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3352\/jeehp.2021.18.17","article-title":"Sample size determination and power analysis using the G*Power software","volume":"18","author":"Kang","year":"2021","journal-title":"J. Educ. Eval. Health Prof."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"6656917","DOI":"10.1155\/2021\/6656917","article-title":"Central Sensitization in Neurological, Psychiatric, and Pain Disorders: A Multicenter Case-Controlled Study","volume":"2021","author":"Suzuki","year":"2021","journal-title":"Pain Res. Manag."},{"key":"ref_45","first-page":"61","article-title":"Influence of vision on masticatory muscles function: Surface electromyographic evaluation","volume":"5","author":"Ciavarella","year":"2014","journal-title":"Ann. Di Stomatol."},{"key":"ref_46","unstructured":"Somisetty, S., and M Das, J. (2022). StatPearls, StatPearls Publishing."},{"key":"ref_47","first-page":"248","article-title":"The Relationship between Posture and Equilibrium and the Auriculotemporal Nerve in Patients with Disturbed Gait and Balance","volume":"27","author":"Stack","year":"2009","journal-title":"Cranio J. Craniomandib. Pract."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00221-008-1674-4","article-title":"Algesic agents exciting muscle nociceptors","volume":"196","author":"Mense","year":"2009","journal-title":"Exp. Brain Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1152\/physrev.00043.2006","article-title":"Physiology and Pathophysiology of Purinergic Neurotransmission","volume":"87","author":"Burnstock","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4680603","DOI":"10.1155\/2018\/4680603","article-title":"Early Intervention and Nonpharmacological Therapy of Myopia in Young Adults","volume":"2018","author":"Zorena","year":"2018","journal-title":"J. Ophthalmol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"45977","DOI":"10.1038\/srep45977","article-title":"Phenotypic and genotypic correlation between myopia and intelligence","volume":"7","author":"Williams","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.jelekin.2013.05.009","article-title":"Differential effects of mental concentration and acute psychosocial stress on cervical muscle activity and posture","volume":"23","author":"Shahidi","year":"2013","journal-title":"J. Electromyogr. Kinesiol. Off. J. Int. Soc. Electrophysiol. Kinesiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.math.2005.01.005","article-title":"A comparison of symptomatic and asymptomatic office workers performing monotonous keyboard work\u20142: Neck and shoulder kinematics","volume":"10","author":"Szeto","year":"2005","journal-title":"Man. Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/00140139.2010.544765","article-title":"Changes in mechanical load and extensor muscle activity in the cervico-thoracic spine induced by sitting posture modification","volume":"54","author":"Edmondston","year":"2011","journal-title":"Ergonomics"},{"key":"ref_55","first-page":"2841","article-title":"Acute Psychosocial Stress Induces a Myopic Shift in Undergraduate Students","volume":"52","author":"Edwards","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e01594","DOI":"10.1002\/brb3.1594","article-title":"Investigation of the psychological health of first-year high school students with myopia in Guangzhou","volume":"10","author":"Li","year":"2020","journal-title":"Brain Behav."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"774237","DOI":"10.3389\/fpubh.2021.774237","article-title":"Relationship Between Myopia and Other Risk Factors With Anxiety and Depression Among Chinese University Freshmen During the COVID-19 Pandemic","volume":"9","author":"Zhang","year":"2021","journal-title":"Front. Public Health"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1167\/iovs.62.10.36","article-title":"Myopia Progression as a Function of Sex, Age, and Ethnicity","volume":"62","author":"Sinnott","year":"2021","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1167\/iovs.61.13.20","article-title":"Racial and Ethnic Differences in Myopia Progression in a Large, Diverse Cohort of Pediatric Patients","volume":"61","author":"Luong","year":"2020","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.msksp.2018.04.009","article-title":"The Central Sensitization Inventory and Pain Sensitivity Questionnaire: An exploration of construct validity and associations with widespread pain sensitivity among individuals with shoulder pain","volume":"36","author":"Coronado","year":"2018","journal-title":"Musculoskelet. Sci. Pract."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/5\/4524\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:47:13Z","timestamp":1760122033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/5\/4524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,3]]},"references-count":60,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["ijerph20054524"],"URL":"https:\/\/doi.org\/10.3390\/ijerph20054524","relation":{},"ISSN":["1660-4601"],"issn-type":[{"type":"electronic","value":"1660-4601"}],"subject":[],"published":{"date-parts":[[2023,3,3]]}}}