{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:50:50Z","timestamp":1789829450063,"version":"4.0.1"},"reference-count":35,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673118"],"award-info":[{"award-number":["81673118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91743114"],"award-info":[{"award-number":["91743114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The inflammatory effects of air pollution exposure may account for increased public health risk. However, evidence regarding the effects of air pollution on peripheral blood leukocytes in the population is inconsistent. We investigated the association between the short-term effects of ambient air pollution and the peripheral blood leukocyte distribution in adult men in Beijing, China. From January 2015 to December 2019, a total of 11,035 men aged 22\u201345 years in Beijing were included in the study. Their peripheral blood routine parameters were measured. The ambient pollution monitoring parameters (particulate matter \u2264 10 \u00b5m (PM10), PM2.5, nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO), and ozone (O3)) were collected daily. The potential association between ambient air pollution exposure and peripheral blood leukocyte count and classification was analyzed with generalized additive models (GAMs). After adjusting for confounding factors, PM2.5, PM10, SO2, NO2, O3, and CO were significantly correlated with changes to at least one peripheral leukocyte subtype. Short-term and cumulative air pollutant exposure dramatically increased the participants\u2019 peripheral blood neutrophil, lymphocyte, and monocyte numbers and decreased eosinophils and basophils. Our results demonstrated that air pollution induced inflammation in the participants. The peripheral leukocyte count and classification can be utilized to evaluate the inflammation induced by air pollution in the exposed male population.<\/jats:p>","DOI":"10.3390\/ijerph20064695","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T03:37:05Z","timestamp":1678160225000},"page":"4695","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Associations between Short-Term Air Pollution Exposure and the Peripheral Leukocyte Distribution in the Adult Male Population in Beijing, China"],"prefix":"10.3390","volume":"20","author":[{"given":"Yuting","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pai","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0258-3986","authenticated-orcid":false,"given":"Guiping","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China"},{"name":"School of Medical Science and Engineering, Beihang University, Beijing 100191, China"},{"name":"Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7875-7930","authenticated-orcid":false,"given":"Yulin","family":"Kang","sequence":"additional","affiliation":[{"name":"Institute of Environmental Information, Chinese Research Academy of Environmental Sciences, Beijing 100012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4407-455X","authenticated-orcid":false,"given":"Tiancheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s12199-007-0018-5","article-title":"Air pollution and population health: A global challenge","volume":"13","author":"Chen","year":"2008","journal-title":"Environ. 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