{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:08:59Z","timestamp":1791493739828,"version":"4.3.4"},"reference-count":34,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Laryngeal cancer is an important oncological entity in which prognosis depends on the establishment of appropriate preventive and diagnostic measures, especially in high-risk populations. We present a retrospective two-year study (January 2021 to December 2022) with 152 patients diagnosed with laryngeal cancer from a tertiary hospital in Romania. The average age of the patients was 62 years old for both sexes, with a range from 44 to 83 years. The most frequent symptom was dysphonia with or without dyspnea in 142 cases (93.42%), followed by dyspnea alone in nine patients (5.92%) and dysphagia in one case (0.66%). Surgical treatment in this study consisted of partial laryngectomy (CO2 laser transoral tumor ablation, supraglottic horizontal laryngectomy or hemilaryngectomy), or total laryngectomy. The main treatment was total laryngectomy (63%). For the eight patients with initial organ preservation treatment, the average time of recurrence was about two-and-a-half years. For the four patients who underwent a total circular pharyngo-laryngectomy, the upper digestive tract needed to be rebuilt with a salivary bypass tube or with a tubed myocutaneous flap from the major pectoralis muscle. One strong point is characteristic of the study group in gathering patients with advanced stages of laryngeal carcinoma candidates for salvage surgery and extended reconstruction methods. The development of new prevention protocols is mandatory in Eastern European countries.<\/jats:p>","DOI":"10.3390\/ijerph20064737","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T02:30:23Z","timestamp":1678242623000},"page":"4737","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Management of Locally Advanced Laryngeal Cancer\u2014From Risk Factors to Treatment, the Experience of a Tertiary Hospital from Eastern Europe"],"prefix":"10.3390","volume":"20","author":[{"given":"Anca-Ionela","family":"C\u00eerstea","sequence":"first","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophtalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of ENT, Head and Neck Surgery, Colt\u0327ea Clinical Hospital, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0218erban Vifor Gabriel","family":"Berte\u0219teanu","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophtalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of ENT, Head and Neck Surgery, Colt\u0327ea Clinical Hospital, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0103zvan-Valentin","family":"Sc\u0103una\u0219u","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophtalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of General Surgery, Colt\u0327ea Clinical Hospital, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophtalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of ENT, Head and Neck Surgery, Colt\u0327ea Clinical Hospital, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Luiza","family":"Bejenaru","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophtalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catrinel Beatrice","family":"Simion-Antonie","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophtalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria Simona","family":"Berte\u0219teanu","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophtalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of ENT, Head and Neck Surgery, \u201cCarol Davila\u201d Emergency Central Military Hospital, 010825 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodora Elena","family":"Diaconu","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophtalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of ENT, Head and Neck Surgery, Colt\u0327ea Clinical Hospital, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra Bianca","family":"Taher","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophtalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of ENT, Head and Neck Surgery, Colt\u0327ea Clinical Hospital, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona-Andreea","family":"Rujan","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophtalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of ENT, Head and Neck Surgery, Colt\u0327ea Clinical Hospital, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina-Doini\u021ba","family":"Oa\u0219\u0103","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophtalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of ENT, Head and Neck Surgery, Colt\u0327ea Clinical Hospital, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca","family":"Grigore","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophtalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of ENT, Head and Neck Surgery, Colt\u0327ea Clinical Hospital, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"ref_1","unstructured":"(2022, November 02). GLOBOCAN 2020. Available online: https:\/\/gco.iarc.fr\/today."},{"key":"ref_2","unstructured":"Koroulakis, A., and Agarwal, M. (2022, November 02). Laryngeal Cancer, StatPearls, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/30252332\/."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e0015","DOI":"10.5041\/RMMJ.10149","article-title":"Management of advanced laryngeal cancer","volume":"5","author":"Sheahan","year":"2014","journal-title":"Rambam Maimonides Med. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.radonc.2013.08.016","article-title":"A systematic review of current and emerging approaches in the field of larynx preservation","volume":"110","author":"Denaro","year":"2014","journal-title":"Radiother. Oncol."},{"key":"ref_5","first-page":"242","article-title":"Pharyngocutaneous fistula onset after total laryngectomy: Scintigraphic analysis","volume":"29","author":"Galli","year":"2009","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_6","unstructured":"Edge, S.B., Byrd, D.R., Compton, C.C., Fritz, A.G., Greene, F.L., and Trotti, A. (2010). Larynx AJCC Cancer Staging Manual, Springer. [7th ed.]."},{"key":"ref_7","unstructured":"(2022, November 03). Centers for Disease Control and Prevention, Available online: https:\/\/www.cdc.gov\/nchs\/nhis\/tobacco\/tobacco_glossary.htm."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.21147\/j.issn.1000-9604.2020.01.03","article-title":"Updates on larynx cancer epidemiology","volume":"32","author":"Nocini","year":"2020","journal-title":"Chin. J. Cancer Res."},{"key":"ref_9","unstructured":"(2022, December 13). Macrotrends. Available online: https:\/\/www.macrotrends.net\/countries\/ROU\/romania\/smoking-rate-statistics."},{"key":"ref_10","unstructured":"(2022, December 13). Eurostat. Available online: https:\/\/ec.europa.eu\/eurostat\/web\/products-eurostat-news\/-\/edn-20211112-1."},{"key":"ref_11","first-page":"353","article-title":"Demography of laryngeal cancer at the Instituto Nacional de Cancerologia in Mexico City","volume":"77","author":"Ortiz","year":"2009","journal-title":"Cir. Cir."},{"key":"ref_12","first-page":"355","article-title":"Epidemiology, risk factors, and overall survival rate of laryngeal cancer in Songklanagarind Hospital","volume":"94","author":"Dechaphunkul","year":"2011","journal-title":"J. Med. Assoc. Thail."},{"key":"ref_13","first-page":"313","article-title":"Laryngeal cancer: Epidemiological data from Northern Greece and review of the literature","volume":"17","author":"Markou","year":"2013","journal-title":"Hippokratia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"153","DOI":"10.47162\/RJME.63.1.16","article-title":"Laryngeal malignancies\u2014Epidemiological data and particularities of the cases diagnosed in Western Romania","volume":"63","author":"Sitaru","year":"2022","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Dyckhoff, G., Plinkert, P.K., and Ramroth, H. (2017). A change in the study evaluation paradigm reveals that larynx preservation compromises survival in T4 laryngeal cancer patients. BMC Cancer, 17.","DOI":"10.1186\/s12885-017-3608-7"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1200\/JCO.2017.75.7385","article-title":"Use of Larynx-Preservation Strategies in the Treatment of Laryngeal Cancer: American Society of Clinical Oncology Clinical Practice Guideline","volume":"36","author":"Forastiere","year":"2018","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/hed.23337","article-title":"Pharyngocutaneous fistula after salvage laryngectomy: Impact of interval between radiotherapy and surgery, and performance of bilateral neck dissection","volume":"36","author":"Basheeth","year":"2014","journal-title":"Head Neck"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/cncr.29241","article-title":"Long-term outcomes after surgical or nonsurgical initial therapy for patients with T4 squamous cell carcinoma of the larynx: A 3-decade survey","volume":"121","author":"Rosenthal","year":"2015","journal-title":"Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4137\/CMENT.S8610","article-title":"Cigarette smoking and alcohol ingestion as risk factors for laryngeal squamous cell carcinoma at kenyatta national hospital, Kenya","volume":"5","author":"Menach","year":"2012","journal-title":"Clin. Med. Insights Ear Nose Throat"},{"key":"ref_20","first-page":"18198","article-title":"Role of Pectoralis Major Myocutaneous Flap in Laryngectomy Surgery: Single Surgeon Experience","volume":"13","author":"Bathula","year":"2021","journal-title":"Cureus"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/lio2.430","article-title":"Reconstruction technique following total laryngectomy affects swallowing outcomes","volume":"5","author":"Harris","year":"2020","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-4274(81)90039-4","article-title":"Factors affecting the distribution of tobacco smoke-induced lesions in the rodent larynx","volume":"9","author":"Lewis","year":"1981","journal-title":"Toxicol. Lett."},{"key":"ref_23","unstructured":"Martonen, T.B. (1985). Surrogate Experimental Models for Studying Particle Deposition in the Human Respiratory Tract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1093\/jnci\/81.23.1828","article-title":"Difference in incidence rates of cancers of the respiratory tract by anatomic subsite and histologic type: An etiologic implication","volume":"81","author":"Yang","year":"1989","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Martinez-Sanchez, J.M., Fernandez, E., and Fu, M. (2010). Smoking behaviour, involuntary smoking, attitudes towards smoke-free legislations, and tobacco control activities in the European Union. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013881"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"103851","DOI":"10.1016\/j.amsu.2022.103851","article-title":"Primary carcinoma of the larynx in females: A case series","volume":"78","author":"Oukessou","year":"2022","journal-title":"Ann. Med. Surg."},{"key":"ref_27","first-page":"514","article-title":"Laryngeal cancer in women: Tobacco, alcohol, nutritional, and hormonal factors","volume":"12","author":"Gallus","year":"2003","journal-title":"Cancer Epidemiol. Biomark. Prev. Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s12672-013-0161-y","article-title":"17 Beta-Estradiol promotes aggressive laryngeal cancer through membrane-associated estrogen receptor-alpha 36","volume":"5","author":"Schwartz","year":"2014","journal-title":"Horm. Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"779153","DOI":"10.3389\/fonc.2021.779153","article-title":"Identification of Novel Prognostic Markers Associated With Laryngeal Squamous Cell Carcinoma Using Comprehensive Analysis","volume":"11","author":"Huang","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.oraloncology.2017.08.009","article-title":"Poor oral health affects survival in head and neck cancer","volume":"73","author":"Farquhar","year":"2017","journal-title":"Oral Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1093\/annonc\/mdw224","article-title":"The role of oral hygiene in head and neck cancer: Results from International Head and Neck Cancer Epidemiology (INHANCE) consortium","volume":"27","author":"Hashim","year":"2016","journal-title":"Ann. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"E631","DOI":"10.1002\/hed.24061","article-title":"Quality compared to quantity of life in laryngeal cancer: A time trade-off study","volume":"38","author":"Hamilton","year":"2015","journal-title":"Head Neck"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1093\/annonc\/mds065","article-title":"Laryngeal preservation with induction chemotherapy for hypopharyngeal squamous cell carcinoma: 10-year results of EORTC trial 24891","volume":"23","author":"Lefebvre","year":"2012","journal-title":"Ann. Oncol. Off. J. Eur. Soc. Med. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1590\/S1808-86942010000200013","article-title":"Assessment of disease-free survival in patients with laryngeal squamous cell carcinoma treated with radiotherapy associated or not with chemotherapy","volume":"76","author":"Chedid","year":"2010","journal-title":"Braz. J. Otorhinolaryngol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/6\/4737\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:50:29Z","timestamp":1760122229000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/6\/4737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,8]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["ijerph20064737"],"URL":"https:\/\/doi.org\/10.3390\/ijerph20064737","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,8]]}}}