{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:22:13Z","timestamp":1791728533982,"version":"4.3.4"},"reference-count":45,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The global coronavirus pandemic has significantly impacted public health and has been a research subject since its emergence in 2019. The acute phase of the disease leads to pulmonary and non-pulmonary manifestations, which in some individuals may progress to long-lasting symptoms. In this article, we conducted a narrative review of the current literature to summarize current knowledge regarding long COVID syndrome in children, focusing on cognitive symptoms. The review included a search of three databases (PubMed, Embase, and Web of Science) using the key phrases \u201cpost COVID-19 cognitive pediatric\u201d, \u201clong COVID pediatric\u201d, \u201cmental health long COVID children\u201d, and \u201cCOVID-19 cognitive symptoms\u201d. A total of 102 studies were included. The review revealed that the main long-term cognitive symptoms following COVID-19 were memory and concentration deficits, sleep disturbances, and psychiatric states such as anxiety and stress. In addition to the direct physiological effects of a viral infection, there are psychological, behavioral, and social factors contributing to cognitive impairment, which should be addressed regarding the pediatric population. The high prevalence of neurocognitive symptoms in children following COVID-19 emphasizes the importance of understanding the mechanisms of nervous system involvement.<\/jats:p>","DOI":"10.3390\/ijerph20065061","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:04:46Z","timestamp":1678763086000},"page":"5061","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Cognition and Mental Health in Pediatric Patients Following COVID-19"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3283-1258","authenticated-orcid":false,"given":"Hadar","family":"Avittan","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Riga Stradi\u0146\u0161 University, Dzirciema Street 16, LV 1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8788-0204","authenticated-orcid":false,"given":"Dmitrijs","family":"Kustovs","sequence":"additional","affiliation":[{"name":"Department of pharmacology, Riga Stradins University, Dzirciema Street 16, LV 1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"ref_1","unstructured":"WHO (2022, December 11). COVID-19 Detailed Surveillance Data Dashboard. Available online: https:\/\/covid19.who.int\/."},{"key":"ref_2","unstructured":"(2022, December 11). Children and COVID-19: State-Level Data Report. Available online: http:\/\/services.aap.org\/en\/pages\/2019-novel-coronavirus-covid-19-infections\/children-and-covid-19-state-level-data-report\/."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1016\/S1473-3099(21)00703-9","article-title":"A Clinical Case Definition of Post-COVID-19 Condition by a Delphi Consensus","volume":"22","author":"Soriano","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"ref_4","unstructured":"(2022, December 20). Long COVID Definition Developed by the Department of Health and Human Services (HHS) in Collaboration with CDC and Other Partners, Available online: https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/long-term-effects\/index.html."},{"key":"ref_5","unstructured":"WHO (2023, February 28). Adolescent Health. Available online: https:\/\/www.who.int\/health-topics\/adolescent-health#tab=tab_1."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Awan, H.A., Najmuddin Diwan, M., Aamir, A., Ali, M., Di Giannantonio, M., Ullah, I., Shoib, S., and De Berardis, D. (2021). SARS-Cov-2 and the Brain: What Do We Know about the Causality of \u2018cognitive COVID?. J. Clin. Med., 10.","DOI":"10.3390\/jcm10153441"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1097\/PHM.0000000000001896","article-title":"Postacute\/Long COVID in Pediatrics: Development of a Multidisciplinary Rehabilitation Clinic and Preliminary Case Series","volume":"100","author":"Morrow","year":"2021","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Munblit, D., Nicholson, T.R., Needham, D.M., Seylanova, N., Parr, C., Chen, J., Kokorina, A., Sigfrid, L., Buonsenso, D., and Bhatnagar, S. (2022). Studying the Post-COVID-19 Condition: Research Challenges, Strategies, and Importance of Core Outcome Set Development. BMC Med., 20.","DOI":"10.1186\/s12916-021-02222-y"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.neurop.2021.10.005","article-title":"Cognitive Symptoms after COVID-19","volume":"1","author":"Altuna","year":"2021","journal-title":"Neurol. Perspect."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e482","DOI":"10.1097\/INF.0000000000003328","article-title":"How Common is Long COVID in Children and Adolescents?","volume":"40","author":"Zimmermann","year":"2021","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"752385","DOI":"10.3389\/fped.2021.752385","article-title":"Comparison of Persistent Symptoms after COVID-19 and Other Non-SARS-CoV-2 Infections in Children","volume":"9","author":"Roge","year":"2021","journal-title":"Front. Pediatr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jinf.2021.11.011","article-title":"Persistent Symptoms Following SARS-CoV-2 Infection amongst Children and Young People: A Meta-Analysis of Controlled and Uncontrolled Studies","volume":"84","author":"Behnood","year":"2022","journal-title":"J. Infect."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"894204","DOI":"10.3389\/fped.2022.894204","article-title":"Post COVID-19 Condition in Children and Adolescents: An Emerging Problem","volume":"10","author":"Dalmau","year":"2022","journal-title":"Front. Pediatr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e509","DOI":"10.1097\/INF.0000000000003285","article-title":"Long COVID in Children: Observations from a Designated Pediatric Clinic","volume":"40","author":"Shmueli","year":"2021","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/arclin\/acac056","article-title":"refegnitive and Psychosocial Characteristics of Pediatric Patients with Post-Acute\/Long-COVID: A Retrospective Clinical Case Series","volume":"37","author":"Ng","year":"2022","journal-title":"Arch. Clin. Neuropsychol. Off. J. Natl. Acad. Neuropsychol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/apa.15673","article-title":"Case report and systematic review suggest that children may experience similar long-term effects to adults after clinical COVID-19","volume":"110","author":"Ludvigsson","year":"1992","journal-title":"Acta Paediatr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s00259-021-05528-4","article-title":"Similar patterns of [18F]-FDG brain PET hypometabolism in paediatric and adult patients with long COVID: A paediatric case series","volume":"49","author":"Morand","year":"2021","journal-title":"Eur. J. Nucl. Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Mohamed, M.S., Johansson, A., Jonsson, J., and Schi\u00f6th, H.B. (2022). Dissecting the Molecular Mechanisms Surrounding Post-COVID-19 Syndrome and Neurological Features. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084275"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/cmi.2015.95","article-title":"\u201cMolecular mechanisms regulating NLRP3 inflammasome activation","volume":"13","author":"Jo","year":"2015","journal-title":"Cell. Mol. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/alz.12644","article-title":"Changes in Cognitive Functioning after COVID-19: A Systematic Review and Meta-Analysis","volume":"18","author":"Crivelli","year":"2022","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1002\/ppul.25521","article-title":"Pediatric long-COVID: An overlooked phenomenon?","volume":"56","author":"Brackel","year":"2021","journal-title":"Pediatr. Pulmonol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1111\/apa.15870","article-title":"Preliminary evidence on long COVID in children","volume":"110","author":"Buonsenso","year":"2021","journal-title":"Acta Paediatr."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Gonzalez-Aumatell, A., Bovo, M.V., Carreras-Abad, C., Cuso-Perez, S., Marsal, D., Coll-Fern\u00e1ndez, R., Calvo, A.G., Giralt-L\u00f3pez, M., Cantallops, A.E., and Moron-Lopez, S. (2022). Social, Academic, and Health Status Impact of Long COVID on Children and Young People: An Observational, Descriptive, and Longitudinal Cohort Study. Children, 9.","DOI":"10.3390\/children9111677"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e056366","DOI":"10.1136\/bmjopen-2021-056366","article-title":"I Can\u2019t Cope with Multiple Inputs\u2019: A Qualitative Study of the Lived Experience of Brain Fog\u2019 after COVID-19","volume":"12","author":"Callan","year":"2022","journal-title":"BMJ Open"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2217\/fmb-2021-0285","article-title":"Clinical characteristics, activity levels and mental health problems in children with long coronavirus disease: A survey of 510 children","volume":"17","author":"Buonsenso","year":"2022","journal-title":"Futur. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S2352-4642(22)00022-0","article-title":"Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): A national matched cohort study","volume":"6","author":"Stephenson","year":"2022","journal-title":"Lancet Child Adolesc. Health"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1097\/INF.0000000000003477","article-title":"Pediatric Long COVID and Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome","volume":"41","author":"Siberry","year":"2022","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_28","first-page":"483","article-title":"Delirium Pedi\u00e1trico Em Tempos Da COVID-19","volume":"33","year":"2022","journal-title":"Rev. Bras. Ter. Intensiv."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/CCM.0000000000005260","article-title":"A Systematic Review and Pooled Prevalence of Delirium in Critically Ill Children*","volume":"50","author":"Semple","year":"2021","journal-title":"Crit. Care Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-020-02882-x","article-title":"COVID-19: ICU delirium management during SARS-CoV-2 pandemic","volume":"24","author":"Kotfis","year":"2020","journal-title":"Crit. Care"},{"key":"ref_31","first-page":"131","article-title":"Pediatric COVID-19 Delirium: Case Report of 2 Adolescents","volume":"120","author":"Bauer","year":"2021","journal-title":"Wis. Med. J."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Maltezou, H.C., Pavli, A., and Tsakris, A. (2021). Post-COVID Syndrome: An Insight on Its Pathogenesis. Vaccines, 9.","DOI":"10.3390\/vaccines9050497"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1152\/physrev.00046.2019","article-title":"Brain mechanisms of insomnia: New perspectives on causes and consequences","volume":"101","year":"2021","journal-title":"Physiol. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s12519-021-00457-6","article-title":"Long COVID in Children and Adolescents","volume":"17","author":"Nemati","year":"2021","journal-title":"World J. Pediatr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"101591","DOI":"10.1016\/j.smrv.2022.101591","article-title":"Sleep disturbances during the COVID-19 pandemic: A systematic review, meta-analysis, and meta-regression","volume":"62","author":"Jahrami","year":"2022","journal-title":"Sleep Med. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s10880-021-09816-x","article-title":"Intolerance of Uncertainty and Health-Related Anxiety in Youth amid the COVID-19 Pandemic: Understanding and Weathering the Continuing Storm","volume":"29","author":"Korte","year":"2021","journal-title":"J. Clin. Psychol. Med. Settings"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-022-06166-y","article-title":"Comparison of mental health outcomes in seropositive and seronegative adolescents during the COVID19 pandemic","volume":"12","author":"Blankenburg","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1001\/archpedi.153.3.254","article-title":"Use of the Pediatric Symptom Checklist to Screen for Psychosocial Problems in Pediatric Primary Care","volume":"153","author":"Jellinek","year":"1999","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Roessler, M., Tesch, F., Batram, M., Jacob, J., Loser, F., Weidinger, O., Wende, D., Vivirito, A., Toepfner, N., and Ehm, F. (2022). Post-COVID-19-associated morbidity in children, adolescents, and adults: A matched cohort study including more than 157,000 individuals with COVID-19 in Germany. PLOS Med., 19.","DOI":"10.1371\/journal.pmed.1004122"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1002\/ppul.25413","article-title":"Psychological Interventions during COVID Pandemic: Telehealth for Individuals with Cystic Fibrosis and Caregivers","volume":"56","author":"Graziano","year":"2021","journal-title":"Pediatr. Pulmonol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Buonsenso, D., Pazukhina, E., Gentili, C., Vetrugno, L., Morello, R., Zona, M., De Matteis, A., D\u2019Ilario, F., Lanni, R., and Rongai, T. (2022). The Prevalence, Characteristics and Risk Factors of Persistent Symptoms in Non-Hospitalized and Hospitalized Children with SARS-CoV-2 Infection Followed-Up for up to 12 Months: A Prospective, Cohort Study in Rome, Italy. J. Clin. Med., 11.","DOI":"10.3390\/jcm11226772"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/da.22588","article-title":"Improving late life depression and cognitive control through the use of therapeutic video game technology: A proof-of-concept randomized trial","volume":"34","author":"Anguera","year":"2017","journal-title":"Depress. Anxiety"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/YCO.0000000000000713","article-title":"A systematic review of neuropsychological and psychiatric sequalae of COVID-19: Implications for treatment","volume":"34","author":"Vanderlind","year":"2021","journal-title":"Curr. Opin. Psychiatry"},{"key":"ref_44","first-page":"1","article-title":"Interventions to improve the mental health of children and young people with long-term physical conditions: Linked evidence syntheses","volume":"23","author":"Nunns","year":"2019","journal-title":"Health Technol. Assess."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1036556","DOI":"10.3389\/fmed.2022.1036556","article-title":"Lifestyle, course of COVID-19, and risk of Long-COVID in non-hospitalized patients","volume":"9","author":"Chudzik","year":"2022","journal-title":"Front. Med."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/6\/5061\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:53:59Z","timestamp":1760122439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/6\/5061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,13]]},"references-count":45,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["ijerph20065061"],"URL":"https:\/\/doi.org\/10.3390\/ijerph20065061","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,13]]}}}