{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:18:28Z","timestamp":1762273108109,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japanese Science and Technology Agency (JST)","doi-asserted-by":"publisher","award":["JPMJCE1301","JPMJSP2124"],"award-info":[{"award-number":["JPMJCE1301","JPMJSP2124"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"JST SPRING","doi-asserted-by":"publisher","award":["JPMJCE1301","JPMJSP2124"],"award-info":[{"award-number":["JPMJCE1301","JPMJSP2124"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Diabetic overweight patients are more likely to show the progression of kidney damage than the general population. The majority of people in the early stages of kidney damage do not recognize the importance of risk modification, mainly due to the asymptomatic nature of the disease. This study aimed to examine specific risk combinations of lifestyle and BMI regarding the deterioration of kidney function and to explore whether there are gender-based differences among the prediabetic population. Prediabetic participants with normal kidney function were identified via annual health examination from April 2016 to March 2019. The information on health status and lifestyle was collected at enrollment. The study subjects were followed until March 2021 to observe the progression of kidney damage. There were 2241 participants enrolled in this study. Smoking (HR = 3.5, p &lt; 0.001), eating snacks (HR = 3.2, p &lt; 0.001), not engaging in regular exercise (HR = 2.9, p &lt; 0.001), and not having adequate sleep (HR = 3.0, p &lt; 0.001) showed accelerated risks for kidney damage progression among the prediabetic population in males. These lifestyle effects were not observed in females. In conclusion, risk-based modification of lifestyle behavior is important to prevent kidney function damage among the overweight prediabetic population in males.<\/jats:p>","DOI":"10.3390\/ijerph20075338","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T02:08:01Z","timestamp":1680228481000},"page":"5338","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Combination of Risks of BMI and Health-Related Lifestyles on Kidney Function in the Prediabetic Japanese Population: A Prospective Cohort Study"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1638-8663","authenticated-orcid":false,"given":"Jou-Yin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Clinical Trials and Clinical Epidemiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqi","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Clinical Trials and Clinical Epidemiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Wagatsuma","sequence":"additional","affiliation":[{"name":"Department of Clinical Trials and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1093\/ndt\/gfq062","article-title":"Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population: The Hisayama Study","volume":"25","author":"Nagata","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.7326\/0003-4819-139-2-200307150-00013","article-title":"National Kidney Foundation practice guidelines for chronic kidney disease: Evaluation, classification, and stratification","volume":"139","author":"Levey","year":"2003","journal-title":"Ann. Intern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e000902","DOI":"10.1136\/bmjdrc-2019-000902","article-title":"Conditions, pathogenesis, and progression of diabetic kidney disease and early decliner in Japan","volume":"8","author":"Yoshida","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1001\/jama.2011.861","article-title":"Temporal trends in the prevalence of diabetic kidney disease in the United States","volume":"305","author":"Rue","year":"2011","journal-title":"JAMA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1098-3597(03)90014-7","article-title":"Diabetic nephropathy","volume":"5","author":"Rabkin","year":"2003","journal-title":"Clin. Cornerstone"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1681\/ASN.2012070718","article-title":"Kidney disease and increased mortality risk in type 2 diabetes","volume":"24","author":"Afkarian","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/qjmed\/95.6.371","article-title":"Natural history and prognostic factors of diabetic nephropathy in type 2 diabetes","volume":"95","author":"Jude","year":"2002","journal-title":"QJM"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"224","DOI":"10.4093\/dmj.2017.0065","article-title":"Higher Prevalence and Progression Rate of Chronic Kidney Disease in Elderly Patients with Type 2 Diabetes Mellitus","volume":"42","author":"Kim","year":"2018","journal-title":"Diabetes Metab. J."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Thornton Snider, J., Sullivan, J., van Eijndhoven, E., Hansen, M.K., Bellosillo, N., Neslusan, C., O\u2019Brien, E., Riley, R., Seabury, S., and Kasiske, B.L. (2019). Lifetime benefits of early detection and treatment of diabetic kidney disease. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0217487"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"752","DOI":"10.34067\/KID.0003122021","article-title":"Modifiable Lifestyle Behaviors and CKD Progression: A Narrative Review","volume":"3","author":"Schrauben","year":"2022","journal-title":"Kidney360"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e34029","DOI":"10.2196\/34029","article-title":"A Lifestyle Intervention to Delay Early Chronic Kidney Disease in African Americans with Diabetic Kidney Disease: Pre-Post Pilot Study","volume":"6","author":"Ozieh","year":"2022","journal-title":"JMIR Form. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11892-015-0625-2","article-title":"Weight loss interventions and progression of diabetic kidney disease","volume":"15","author":"Docherty","year":"2015","journal-title":"Curr. Diabetes Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"10408","DOI":"10.1038\/s41598-019-46857-7","article-title":"Prevalence and risk factors of chronic kidney disease and diabetic kidney disease in Chinese rural residents: A cross-sectional survey","volume":"9","author":"Duan","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1507\/endocrj.EJ17-0415","article-title":"Twelve-year trends of increasing overweight and obesity in patients with diabetes: The Shiga Diabetes Clinical Survey","volume":"65","author":"Miyazawa","year":"2018","journal-title":"Endocr. J."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kim, B.Y., Choi, D.H., Jung, C.H., Mok, J.O., and Kim, C.H. (2021). Associations between obesity, weight change and decreased renal function in Korean type 2 diabetic patients: A longitudinal follow-up study. BMC Endocr. Disord., 21.","DOI":"10.1186\/s12902-021-00853-z"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"440","DOI":"10.2188\/jea.JE20150208","article-title":"Sex Differences in Associations among Obesity, Metabolic Abnormalities, and Chronic Kidney Disease in Japanese Men and Women","volume":"26","author":"Sakurai","year":"2016","journal-title":"J. Epidemiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s13340-020-00439-5","article-title":"Japanese Clinical Practice Guideline for Diabetes 2019","volume":"11","author":"Araki","year":"2020","journal-title":"Diabetol. Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1539\/joh.45.335","article-title":"The new BMI criteria for asians by the regional office for the western pacific region of WHO are suitable for screening of overweight to prevent metabolic syndrome in elder Japanese workers","volume":"45","author":"Anuurad","year":"2003","journal-title":"J. Occup. Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.je.2016.09.013","article-title":"Pre-pregnancy BMI-specific optimal gestational weight gain for women in Japan","volume":"10","author":"Morisaki","year":"2017","journal-title":"J. Epidemiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1053\/j.ajkd.2008.12.034","article-title":"Revised equations for estimated GFR from serum creatinine in Japan","volume":"53","author":"Matsuo","year":"2009","journal-title":"Am. J. Kidney Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"846","DOI":"10.5551\/jat.GL2017","article-title":"Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017","volume":"25","author":"Kinoshita","year":"2018","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1093\/ndt\/gfx230","article-title":"Obesity and synergistic risk factors for chronic kidney disease in African American adults: The Jackson Heart Study","volume":"33","author":"Olivo","year":"2018","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"826383","DOI":"10.3389\/fcdhc.2022.826383","article-title":"Effects of Smoking on Diabetic Nephropathy","volume":"3","year":"2022","journal-title":"Front. Clin. Diabetes Healthc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1161\/01.CIR.98.23.2621","article-title":"Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats","volume":"98","author":"Yu","year":"1998","journal-title":"Circulation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2215\/CJN.03260410","article-title":"Associations of sugar and artificially sweetened soda with albuminuria and kidney function decline in women","volume":"6","author":"Lin","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_26","first-page":"e96","article-title":"Meal Timing and Frequency: Implications for Cardiovascular Disease Prevention: A Scientific Statement from the American Heart Association","volume":"135","author":"Ard","year":"2017","journal-title":"Circulation"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"655871","DOI":"10.3389\/fmed.2021.655871","article-title":"A Nephrologist Perspective on Obesity: From Kidney Injury to Clinical Management","volume":"8","author":"Vergara","year":"2021","journal-title":"Front. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7059","DOI":"10.12659\/MSM.916121","article-title":"Alcohol Consumption Can be a \u201cDouble-Edged Sword\u201d for Chronic Kidney Disease Patients","volume":"25","author":"Fan","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.mayocp.2019.06.014","article-title":"Alcohol Consumption and Progression of Chronic Kidney Disease: Results from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease","volume":"95","author":"Joo","year":"2020","journal-title":"Mayo Clin. Proc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1053\/j.jrn.2022.01.015","article-title":"Daily Walking Dose and Health-related Quality of Life in Patients with Chronic Kidney Disease","volume":"32","author":"Xiong","year":"2022","journal-title":"J. Ren. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mcna.2012.10.010","article-title":"Obesity and diabetic kidney disease","volume":"97","year":"2013","journal-title":"Med. Clin. N. Am."},{"key":"ref_32","first-page":"65","article-title":"Obesity and kidney disease","volume":"39","author":"Bentes","year":"2017","journal-title":"J. Bras. Nefrol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3389\/fendo.2020.00289","article-title":"Metabolic Surgery to Treat Obesity in Diabetic Kidney Disease, Chronic Kidney Disease, and End-Stage Kidney Disease; What Are the Unanswered Questions?","volume":"11","author":"Martin","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"314","DOI":"10.2188\/jea.JE20200538","article-title":"Body Fat Distribution, Glucose Metabolism, and Diabetes Status Among Older Adults: The Multiethnic Cohort Adiposity Phenotype Study","volume":"32","author":"Maskarinec","year":"2022","journal-title":"J. Epidemiol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Pop, L.M., Iorga, M., \u0218ipo\u0219, L.R., and Iurcov, R. (2021). Gender Differences in Healthy Lifestyle, Body Consciousness, and the Use of Social Networks among Medical Students. Medicina, 57.","DOI":"10.3390\/medicina57070648"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12937-020-00659-0","article-title":"Gender differences in perceived food healthiness and food avoidance in a Swedish population-based survey: A cross sectional study","volume":"19","author":"Palmqvist","year":"2020","journal-title":"Nutr. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"897","DOI":"10.21037\/atm.2020.03.62","article-title":"Understanding sex differences in progression and prognosis of chronic kidney disease","volume":"8","author":"Kattah","year":"2020","journal-title":"Ann. Transl. Med."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/7\/5338\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:07:22Z","timestamp":1760123242000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/7\/5338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":37,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["ijerph20075338"],"URL":"https:\/\/doi.org\/10.3390\/ijerph20075338","relation":{},"ISSN":["1660-4601"],"issn-type":[{"type":"electronic","value":"1660-4601"}],"subject":[],"published":{"date-parts":[[2023,3,30]]}}}