{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:32:46Z","timestamp":1780979566301,"version":"3.54.1"},"reference-count":80,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Felicia and Jean-Jacques Lopez-Loreta Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>(1) Background: Poor sleep and fragmented sleep are associated with several chronic conditions. Tinnitus is an auditory symptom that often negatively combines with poor sleep and has been associated with sleep impairment and sleep apnea. The relationship between tinnitus psychoacoustic characteristics and sleep is still poorly explored, notably for a particular subgroup of patients, for whom the perceived loudness of their tinnitus is highly modulated by sleep. (2) Methods: For this observational prospective study, 30 subjects with tinnitus were recruited, including 15 \u201csleep intermittent tinnitus\u201d subjects, who had reported significant modulations of tinnitus loudness related to night sleep and naps, and a control group of 15 subjects displaying constant non-sleep-modulated tinnitus. The control group had matching age, gender, self-reported hearing loss grade and tinnitus impact on quality of life with the study group. All patients underwent a polysomnography (PSG) assessment for one complete night and then were asked to fill in a case report form, as well as a report of tinnitus loudness before and after the PSG. (3) Results: \u201cSleep Intermittent tinnitus\u201d subjects had less Stage 3 sleep (p &lt; 0.01), less Rapid-Eye Movement (REM) Sleep (p &lt; 0.05) and more Stage 2 sleep (p &lt; 0.05) in proportion and duration than subjects from the control group. In addition, in the \u201csleep Intermittent tinnitus\u201d sample, a correlation was found between REM sleep duration and tinnitus overnight modulation (p &lt; 0.05), as well as tinnitus impact on quality of life (p &lt; 0.05). These correlations were not present in the control group. (4) Conclusions: This study suggests that among the tinnitus population, patients displaying sleep-modulated tinnitus have deteriorated sleep quality. Furthermore, REM sleep characteristics may play a role in overnight tinnitus modulation. Potential pathophysiological explanations accounting for this observation are hypothesized and discussed.<\/jats:p>","DOI":"10.3390\/ijerph20085509","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T02:03:38Z","timestamp":1681437818000},"page":"5509","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["REM Sleep Impairment May Underlie Sleep-Driven Modulations of Tinnitus in Sleep Intermittent Tinnitus Subjects: A Controlled Study"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7557-5066","authenticated-orcid":false,"given":"Robin","family":"Guillard","sequence":"first","affiliation":[{"name":"GIPSA-Lab, Grenoble INP, CNRS, Universit\u00e9 Grenoble Alpes, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Korczowski","sequence":"additional","affiliation":[{"name":"Robin Guillard EIRL, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1168-480X","authenticated-orcid":false,"given":"Damien","family":"L\u00e9ger","sequence":"additional","affiliation":[{"name":"VIFASOM ERC 7330, Vigilance Fatigue Sommeil et Sant\u00e9 Publique, Universit\u00e9 Paris Cit\u00e9, 75004 Paris, France"},{"name":"Centre du Sommeil et de la Vigilance, H\u00f4tel-Dieu, APHP, 75004 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Congedo","sequence":"additional","affiliation":[{"name":"GIPSA-Lab, Grenoble INP, CNRS, Universit\u00e9 Grenoble Alpes, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3876-0657","authenticated-orcid":false,"given":"Alain","family":"Londero","sequence":"additional","affiliation":[{"name":"Service ORL et Chirurgie Cervico-Faciale, H\u00f4pital Europ\u00e9en Georges-Pompidou, APHP, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.pcad.2008.08.001","article-title":"Epidemiology, Risk Factors, and Consequences of Obstructive Sleep Apnea and Short Sleep Duration","volume":"51","author":"Patel","year":"2009","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.sleep.2016.08.006","article-title":"Short Sleep Duration and Health Outcomes: A Systematic Review, Meta-Analysis, and Meta-Regression","volume":"32","author":"Itani","year":"2017","journal-title":"Sleep Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"von Ruesten, A., Weikert, C., Fietze, I., and Boeing, H. (2012). Association of Sleep Duration with Chronic Diseases in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030972"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Sabia, S., Dugravot, A., L\u00e9ger, D., Ben Hassen, C., Kivimaki, M., and Singh-Manoux, A. (2022). Association of Sleep Duration at Age 50, 60, and 70 Years with Risk of Multimorbidity in the UK: 25-Year Follow-up of the Whitehall II Cohort Study. PLoS Med., 19.","DOI":"10.1371\/journal.pmed.1004109"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.diabres.2010.07.011","article-title":"Diabetes and Sleep: A Complex Cause-and-Effect Relationship","volume":"91","author":"Barone","year":"2011","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.19184\/nlj.v3i2.8580","article-title":"The Correlation Between Fatigue and Sleep Quality among Patients with Heart Failure","volume":"3","author":"Lainsamputty","year":"2018","journal-title":"NurseLine J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0006-3223(93)90260-K","article-title":"Sleep Disturbance Associated with Chronic Tinnitus","volume":"34","author":"Alster","year":"1993","journal-title":"Biol. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4103\/1463-1741.110287","article-title":"Association between Sleep Disorders, Hyperacusis and Tinnitus: Evaluation with Tinnitus Questionnaires","volume":"15","author":"Fioretti","year":"2013","journal-title":"Noise Health"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/AUD.0b013e31812f71cc","article-title":"Sleep Complaints in Elderly Tinnitus Patients: A Controlled Study","volume":"28","author":"Carrier","year":"2007","journal-title":"Ear Hear."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.smrv.2012.04.003","article-title":"Tinnitus and Insomnia: Is Hyperarousal the Common Denominator?","volume":"17","author":"Schredl","year":"2013","journal-title":"Sleep Med. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pbr.2020.12.002","article-title":"Chapter 1-Tinnitus and Tinnitus Disorder: Theoretical and Operational Definitions (an International Multidisciplinary Proposal)","volume":"Volume 260","author":"Schlee","year":"2021","journal-title":"Progress in Brain Research"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1001\/jamaneurol.2022.2189","article-title":"Global Prevalence and Incidence of Tinnitus: A Systematic Review and Meta-Analysis","volume":"79","author":"Jarach","year":"2022","journal-title":"JAMA Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1053\/ajot.2000.9871","article-title":"Tinnitus and Insomnia","volume":"21","author":"Folmer","year":"2000","journal-title":"Am. J. Otolaryngol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1177\/0003489414532779","article-title":"The Effect of Insomnia on Tinnitus","volume":"123","author":"Miguel","year":"2014","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.jfma.2021.07.022","article-title":"Sleep Disturbance and Psychological Distress in Adult Patients with Tinnitus","volume":"121","author":"Li","year":"2022","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_16","first-page":"65","article-title":"Insomnia in Tinnitus Patients: A Prospective Study Finding a Significant Relationship","volume":"24","author":"Asnis","year":"2020","journal-title":"Int. Tinnitus J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1179557318781078","article-title":"An Examination of the Relationship Between Insomnia and Tinnitus: A Review and Recommendations","volume":"9","author":"Asnis","year":"2018","journal-title":"Clin. Med. Insights Psychiatry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3109\/03005368909077819","article-title":"Tinnitus\u2014A Study of Its Prevalence and Characteristics","volume":"23","author":"Axelsson","year":"1989","journal-title":"Br. J. Audiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3109\/01050399609074965","article-title":"Correlates of Sleep Disturbance in Chronic Distressing Tinnitus","volume":"25","author":"Hallam","year":"1996","journal-title":"Scand. Audiol."},{"key":"ref_20","first-page":"139","article-title":"Sleepiness and Sleep in Elderly Persons with Tinnitus","volume":"37","author":"Asplund","year":"2003","journal-title":"Arch. Gerontol."},{"key":"ref_21","first-page":"641","article-title":"Clinical features analysis of 1240 tinnitus cases","volume":"44","author":"Shao","year":"2009","journal-title":"Zhonghua Er. Bi. Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1177\/000348941112000402","article-title":"Prevalence of Insomnia and Impact on Quality of Life among Community Elderly Subjects with Tinnitus","volume":"120","author":"Lasisi","year":"2011","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1177\/000348941312201107","article-title":"Association between Tinnitus and Sleep Disorders in the General Japanese Population","volume":"122","author":"Izuhara","year":"2013","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1365-2869.2010.00860.x","article-title":"Polysomnographic and Quantitative Electroencephalographic Correlates of Subjective Sleep Complaints in Chronic Tinnitus: Sleep Complaints in Tinnitus","volume":"20","author":"Fullum","year":"2011","journal-title":"J. Sleep Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1177\/0003489418805766","article-title":"Polysomnographic Findings in Patients With Chronic Tinnitus","volume":"127","author":"Teixeira","year":"2018","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1055\/s-0037-1603809","article-title":"Polysomnography Applied to Patients with Tinnitus: A Review","volume":"22","author":"Teixeira","year":"2018","journal-title":"Int. Arch. Otorhinolaryngol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/AUD.0b013e31827bc436","article-title":"Sleep Architecture Variation in Chronic Tinnitus Patients","volume":"34","author":"Attanasio","year":"2013","journal-title":"Ear Hear."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Lu, C.-T., Lee, L.-A., Lee, G.-S., and Li, H.-Y. (2022). Obstructive Sleep Apnea and Auditory Dysfunction\u2014Does Snoring Sound Play a Role?. Diagnostics, 12.","DOI":"10.3390\/diagnostics12102374"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1439-054X.2005.00056.x","article-title":"Chronic Tinnitus and Associated Sleep Disturbances","volume":"9","author":"Burgos","year":"2005","journal-title":"Somnologie"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"A354","DOI":"10.1093\/sleep\/zsz067.878","article-title":"Tinnitus Severity in Posttraumatic Stress Disorder (PTSD) is Inversely Correlated with Rapid Eye Movement (REM) Sleep Percentage and Duration and Directly Correlated with Indices of Hyperarousal","volume":"42","author":"Gupta","year":"2019","journal-title":"Sleep"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"fcac089","DOI":"10.1093\/braincomms\/fcac089","article-title":"Tinnitus: At a Crossroad between Phantom Perception and Sleep","volume":"4","author":"Milinski","year":"2022","journal-title":"Brain Commun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1365-2842.2005.01519.x","article-title":"Clinical Evaluation of Tinnitus in Patients with Sleep Bruxism: Prevalence and Characteristics","volume":"32","author":"Camparis","year":"2005","journal-title":"J. Oral Rehabil."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/1807-3107BOR-2014.vol28.0003","article-title":"Association between Painful Temporomandibular Disorders, Sleep Bruxism and Tinnitus","volume":"28","author":"Fernandes","year":"2014","journal-title":"Braz. Oral Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1002\/lary.26323","article-title":"Risk of Tinnitus in Patients with Sleep Apnea: A Nationwide, Population-Based, Case-Control Study","volume":"127","author":"Koo","year":"2017","journal-title":"Laryngoscope"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e30089","DOI":"10.1097\/MD.0000000000030089","article-title":"Sleep Apnea Plays a More Important Role on Sleep N3 Stage than Chronic Tinnitus in Adults","volume":"101","author":"Tseng","year":"2022","journal-title":"Medicine"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.1038\/s41598-020-62987-9","article-title":"Association of Periodic Limb Movements during Sleep and Tinnitus in Humans","volume":"10","author":"Hwang","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jfma.2020.03.014","article-title":"Association of Sleep Terror, Walking or Talking and Tinnitus","volume":"120","author":"Hwang","year":"2021","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fnagi.2019.00053","article-title":"Editorial: Towards an Understanding of Tinnitus Heterogeneity","volume":"11","author":"Cederroth","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Landgrebe, M., Zeman, F., Koller, M., Eberl, Y., Mohr, M., Reiter, J., Staudinger, S., Hajak, G., and Langguth, B. (2010). The Tinnitus Research Initiative (TRI) Database: A New Approach for Delineation of Tinnitus Subtypes and Generation of Predictors for Treatment Outcome. BMC Med. Inf. Decis. Mak., 10.","DOI":"10.1186\/1472-6947-10-42"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/MOO.0000000000000185","article-title":"Treatment of Tinnitus","volume":"23","author":"Langguth","year":"2015","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3389\/fnins.2019.00802","article-title":"Why Is There No Cure for Tinnitus?","volume":"13","author":"McFerran","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_42","first-page":"1","article-title":"One Size Does Not Fit All: Developing Common Standards for Outcomes in Early-Phase Clinical Trials of Sound-, Psychology-, and Pharmacology-Based Interventions for Chronic Subjective Tinnitus in Adults","volume":"23","author":"Hall","year":"2019","journal-title":"Trends Hear."},{"key":"ref_43","first-page":"28","article-title":"Why the One-Size-Fits-All Approach to Tinnitus Is Not Successful","volume":"29","author":"Kim","year":"2022","journal-title":"Hear. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/bs.pbr.2020.05.022","article-title":"Chapter 4-Exploring Tinnitus Heterogeneity","volume":"Volume 260","author":"Schlee","year":"2021","journal-title":"Progress in Brain Research"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/B978-0-444-62630-1.00023-8","article-title":"Tinnitus","volume":"Volume 129","author":"Levine","year":"2015","journal-title":"Handbook of Clinical Neurology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1055\/s-0033-1354603","article-title":"Tinnitus: Diagnostic Approach Leading to Treatment","volume":"33","author":"Levine","year":"2013","journal-title":"Semin. Neurol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.heares.2019.02.017","article-title":"Standardised Profiling for Tinnitus Research: The European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ)","volume":"377","author":"Genitsaridi","year":"2019","journal-title":"Hear. Res."},{"key":"ref_48","first-page":"115","article-title":"Cluster Analysis to Identify Possible Subgroups in Tinnitus Patients","volume":"8","author":"Free","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"111","DOI":"10.17140\/OTLOJ-2-125","article-title":"Somatic Modulation of Tinnitus: A Review and Some Open Questions","volume":"2","author":"Ralli","year":"2016","journal-title":"Otolaryngol. Open J."},{"key":"ref_50","first-page":"37","article-title":"Characteristics of Tinnitus and Etiology of Associated Hearing Loss: A Study of 123 Patients","volume":"8","author":"Faulconhridge","year":"2002","journal-title":"Int. Tinnitus J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.neuron.2010.04.032","article-title":"Tuning Out the Noise: Limbic-Auditory Interactions in Tinnitus","volume":"66","author":"Rauschecker","year":"2010","journal-title":"Neuron"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Guillard, R., Decobecq, F., Fraysse, M.-J., Favre, A., Congedo, M., Loche, V., Boyer, M., and Londero, A. (2023). Validated French Translation of the ESIT-SQ Standardized Tinnitus Screening Questionnaire. Eur. Ann. Otorhinolaryngol. Head Neck Dis.","DOI":"10.1016\/j.anorl.2022.12.007"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1001\/archotol.1996.01890140029007","article-title":"Development of the Tinnitus Handicap Inventory","volume":"122","author":"Newman","year":"1996","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.neuroimage.2006.09.024","article-title":"10\/20, 10\/10, and 10\/5 Systems Revisited: Their Validity as Relative Head-Surface-Based Positioning Systems","volume":"34","author":"Jurcak","year":"2007","journal-title":"NeuroImage"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1177\/00220345960750010601","article-title":"Sleep Bruxism: Validity of Clinical Research Diagnostic Criteria in a Controlled Polysomnographic Study","volume":"75","author":"Lavigne","year":"1996","journal-title":"J. Dent. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11325-014-0986-9","article-title":"Diagnostic Accuracy of Sleep Bruxism Scoring in Absence of Audio-Video Recording: A Pilot Study","volume":"19","author":"Carra","year":"2015","journal-title":"Sleep Breath"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41592-019-0686-2","article-title":"SciPy 1.0: Fundamental Algorithms for Scientific Computing in Python","volume":"17","author":"Virtanen","year":"2020","journal-title":"Nat. Methods"},{"key":"ref_58","unstructured":"Genitsaridi, E. (2021). Novel Approaches for Tinnitus Subphenotyping: Evidence Synthesis, Standardised Assessment, and Supervised and Unsupervised Machine Learning Applications. [Ph.D. Thesis, University of Nottingham]."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fneur.2017.00046","article-title":"Different Patterns of Hearing Loss among Tinnitus Patients: A Latent Class Analysis of a Large Sample","volume":"8","author":"Langguth","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1177\/154405910708600906","article-title":"Identification of a Sleep Bruxism Subgroup with a Higher Risk of Pain","volume":"86","author":"Guitard","year":"2007","journal-title":"J. Dent. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/sleep\/27.7.1255","article-title":"Meta-Analysis of Quantitative Sleep Parameters From Childhood to Old Age in Healthy Individuals: Developing Normative Sleep Values Across the Human Lifespan","volume":"27","author":"Ohayon","year":"2004","journal-title":"Sleep"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1044\/1059-0889(2007\/015)","article-title":"The Association Between Tinnitus and Posttraumatic Stress Disorder","volume":"16","author":"Fagelson","year":"2007","journal-title":"Am. J. Audiol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Fagelson, M. (2022). Tinnitus and Traumatic Memory. Brain Sci., 12.","DOI":"10.3390\/brainsci12111585"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s12529-017-9702-z","article-title":"Tinnitus, Traumatic Brain Injury, and Posttraumatic Stress Disorder in the Military","volume":"25","author":"Moring","year":"2018","journal-title":"Int. J. Behav. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1002\/lary.27841","article-title":"Eye Movement Desensitization and Reprocessing as a Treatment for Tinnitus","volume":"129","author":"Phillips","year":"2019","journal-title":"Laryngoscope"},{"key":"ref_66","first-page":"135","article-title":"EMDR in the Treatment of Chronic Subjective Tinnitus: A Systematic Review","volume":"14","author":"Luyten","year":"2020","journal-title":"J. EMDR Pract. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fnbeh.2016.00052","article-title":"An Integrative Model for the Neural Mechanism of Eye Movement Desensitization and Reprocessing (EMDR)","volume":"10","author":"Coubard","year":"2016","journal-title":"Front. Behav. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3389\/fpsyg.2018.01395","article-title":"How Does Eye Movement Desensitization and Reprocessing Therapy Work? A Systematic Review on Suggested Mechanisms of Action","volume":"9","author":"Pagani","year":"2018","journal-title":"Front. Psychol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1007\/s00221-014-3890-4","article-title":"Trauma Exposure and Sleep: Using a Rodent Model to Understand Sleep Function in PTSD","volume":"232","author":"Vanderheyden","year":"2014","journal-title":"Exp. Brain Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1523\/JNEUROSCI.0820-16.2017","article-title":"Sleep Is for Forgetting","volume":"37","author":"Poe","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1469-8986.1972.tb00757.x","article-title":"The Effects of Continuous, High Intensity, White Noise on the Human Sleep Cycle","volume":"9","author":"Scott","year":"1972","journal-title":"Psychophysiology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"718","DOI":"10.3389\/fneur.2017.00718","article-title":"Broadband Sound Administration Improves Sleep Onset Latency in Healthy Subjects in a Model of Transient Insomnia","volume":"8","author":"Messineo","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_73","first-page":"57","article-title":"Sleep Disturbances Related to Environmental Noise","volume":"4","author":"Griefahn","year":"2002","journal-title":"Noise Health"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/sleep\/4.3.319","article-title":"Persistence of the Circadian Rhythm of REM Sleep: A Variety of Experimental Manipulations of the Sleep-Wake Cycle","volume":"4","author":"Endo","year":"1981","journal-title":"Sleep"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"433","DOI":"10.5665\/sleep.4504","article-title":"Morning REM Sleep Naps Facilitate Broad Access to Emotional Semantic Networks","volume":"38","author":"Carr","year":"2015","journal-title":"Sleep"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1192\/bjp.115.518.107","article-title":"Sleep Patterns During Afternoon Naps in the Young and Elderly","volume":"115","author":"Lewis","year":"1969","journal-title":"Br. J. Psychiatry"},{"key":"ref_77","first-page":"773","article-title":"Spontaneous Middle Ear Muscle Activity in Man: A Rapid Eye Movement Sleep Phenomenon","volume":"178","author":"Pessah","year":"1972","journal-title":"Sci. New Ser."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/sleep\/2.2.199","article-title":"Phasic Events of REM Sleep: Phenomenology of Middle Ear Muscle Activity and Periorbital Integrated Potentials in the Same Normal Population","volume":"2","author":"Benson","year":"1979","journal-title":"Sleep"},{"key":"ref_79","first-page":"454","article-title":"Middle-Ear Muscle Activity (MEMA) and Its Association with Motor Activity in the Extremities and Head in Sleep","volume":"14","author":"Slegel","year":"1991","journal-title":"Sleep"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/sleep\/15.6.567","article-title":"An Inexpensive Alternative for Recording Middle Ear Muscle Activity (MEMA) During Sleep","volume":"15","author":"Slegel","year":"1992","journal-title":"Sleep"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/8\/5509\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:15:37Z","timestamp":1760123737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/8\/5509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,14]]},"references-count":80,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["ijerph20085509"],"URL":"https:\/\/doi.org\/10.3390\/ijerph20085509","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,14]]}}}