{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T18:32:12Z","timestamp":1776709932788,"version":"3.51.2"},"reference-count":34,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>This study aimed to assess the ability of community pharmacists to recognize cases of loperamide abuse at the point of sale, their perspective of and experience toward potential abuse cases. Methods: A cross-sectional study was conducted in Jordan, using a self-administered online questionnaire. The questionnaire consisted of three main parts: demographics, the experience of pharmacists with abusers\u2019 behavior, as well as their perspectives toward loperamide abuse. Results: A total of 250 community pharmacists completed the survey, 54% (135) of which were female. Almost one-third (33.2%; 83) of the participants reported exposure to suspected cases of loperamide abuse during the last six months. Pharmacists declared that most of the suspected loperamide abusers were male (60.2%), of middle\u2013low socioeconomic status (69.9%), and between 20 and 30 years of age (57.8%). The largest quantity (packs) of loperamide requested by a single patient was around 33.2 \u00b1 14.9 at once. As reported by pharmacists, the suspected reasons behind loperamide abuse included 50% seeking euphoria, 17% relieving anxiety, and 33% controlling addiction (weaning off other opioids). The multivariate logistic regression analysis demonstrated a significant correlation between the male sex (OR = 1.2, 95% CI 0.12\u20131.59), pharmacy location in the center of Jordan (OR = 21.2, 95% CI 2.45\u2013183.59), late-night working shift (Shift C, OR = 1.29, 95% CI 0.12\u20132.08), and abuse to loperamide during the last six months. Conclusions: This study sheds light on loperamide abuse potentials, which could be influenced by different sociodemographic characteristics. Accordingly, close monitoring and thorough tackling of the abuse practices are mandated through an increase in educational and awareness campaigns about proper medication use.<\/jats:p>","DOI":"10.3390\/ijerph20146400","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T21:22:58Z","timestamp":1689801778000},"page":"6400","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Perspectives of and Experience toward the Abuse of Antidiarrheal Drug (Loperamide) among Community Pharmacists: A Cross-Sectional Study"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7966-1172","authenticated-orcid":false,"given":"Muna","family":"Barakat","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Therapeutics, School of Pharmacy, Applied Science Private University, Amman 541350, Jordan"},{"name":"MEU Research Unit, Middle East University, Amman 11831, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Akour","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, The University of Jordan, Amman 11942, Jordan"},{"name":"Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Malaeb","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates"},{"name":"School of Pharmacy, Lebanese International University, Beirut 14404, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Cherri","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Lebanese International University, Beirut 14404, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wala\u2019a","family":"Al.Safadi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ala\u2019a","family":"Al.Safadi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Therapeutics, School of Pharmacy, Applied Science Private University, Amman 541350, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-6027","authenticated-orcid":false,"given":"Mayyada","family":"Wazaify","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, The University of Jordan, Amman 11942, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1477-7517-1-3","article-title":"Substance abuse and pharmacy practice: What the community pharmacist needs to know about drug abuse and dependence","volume":"1","author":"Tommasello","year":"2004","journal-title":"Harm Reduct. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s40545-021-00350-7","article-title":"A mixed-methods systematic review of the prevalence, reasons, associated harms and risk-reduction interventions of over-the-counter (OTC) medicines misuse, abuse and dependence in adults","volume":"14","author":"Algarni","year":"2021","journal-title":"J. Pharm. Policy Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1111\/1556-4029.14115","article-title":"Loperamide as a Potential Drug of Abuse and Misuse: Fatal Overdoses at the Medical University of South Carolina","volume":"64","author":"Powell","year":"2019","journal-title":"J. Forensic Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jemermed.2017.03.018","article-title":"Intentional Misuse and Abuse of Loperamide: A New Look at a Drug with \u201cLow Abuse Potential\u201d","volume":"53","author":"Borron","year":"2017","journal-title":"J. Emerg. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/phar.1885","article-title":"Loperamide Trends in Abuse and Misuse Over 13 Years: 2002\u20132015","volume":"37","author":"Lasoff","year":"2017","journal-title":"Pharmacotherapy"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.annemergmed.2016.08.444","article-title":"Epidemiologic Trends in Loperamide Abuse and Misuse","volume":"69","author":"Vakkalanka","year":"2017","journal-title":"Ann. Emerg. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/15563650.2018.1510128","article-title":"Loperamide misuse to avoid opioid withdrawal and to achieve a euphoric effect: High doses and high risk","volume":"57","author":"Lee","year":"2019","journal-title":"Clin. Toxicol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Schifano, F., and Chiappini, S. (2018). Is there such a thing as a \u2018lope\u2019 dope? Analysis of loperamide-related European Medicines Agency (EMA) pharmacovigilance database reports. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0204443"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"E803","DOI":"10.1503\/cmaj.161421","article-title":"Loperamide abuse","volume":"189","author":"Antoniou","year":"2017","journal-title":"Can. Med. Assoc. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"150","DOI":"10.7861\/clinmed.2020-1046","article-title":"Loperamide: An emerging drug of abuse and cause of prolonged QTc","volume":"21","author":"Whittaker","year":"2021","journal-title":"Clin. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/amajethics.2021.471","article-title":"Pharmacist and Prescriber Responsibilities for Avoiding Prescription Drug Misuse","volume":"23","author":"Sun","year":"2021","journal-title":"AMA J. Ethics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.japh.2020.05.021","article-title":"National assessment of pharmacist awareness of loperamide abuse and ability to restrict sale if abuse is suspected","volume":"60","author":"Feldman","year":"2020","journal-title":"J. Am. Pharm. Assoc."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Mobrad, A.M., Alghadeer, S., Syed, W., Al-Arifi, M.N., Azher, A., Almetawazi, M.S., and Babelghaith, S.D. (2020). Knowledge, Attitudes, and Beliefs Regarding Drug Abuse and Misuse among Community Pharmacists in Saudi Arabia. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17041334"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Barakat, M., Al-Qudah, R., Akour, A., Al-Qudah, N., and Dallal Bashi, Y.H. (2020). Unforeseen uses of oral contraceptive pills: Exploratory study in Jordanian community pharmacies. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0244373"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Barakat, M.M., Al-Qudah, R.A.A., Akour, A., Abu-Asal, M., Thiab, S., and Dallal Bashi, Y.H. (2021). The Use\/Abuse of Oral Contraceptive Pills Among Males: A Mixed-Method Explanatory Sequential Study Over Jordanian Community Pharmacists. medRxiv.","DOI":"10.1101\/2021.03.11.21253403"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.3109\/10826080802490683","article-title":"Abuse and Misuse of Prescription and Nonprescription Drugs Sold in Community Pharmacies in Jordan","volume":"45","author":"Wazaify","year":"2010","journal-title":"Subst. Use Misuse"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jsps.2018.01.012","article-title":"Pregabalin dispensing patterns in Amman-Jordan: An observational study from community pharmacies","volume":"26","author":"Wazaify","year":"2018","journal-title":"Saudi Pharm. J."},{"key":"ref_18","unstructured":"Tabachnick, B.G., Fidell, L.S., and Ullman, J.B. (2007). Using Multivariate Statistics, Pearson Boston."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e000262","DOI":"10.1136\/fmch-2019-000262","article-title":"Variable selection strategies and its importance in clinical prediction modelling","volume":"8","author":"Chowdhury","year":"2020","journal-title":"Fam. Med. Community Health"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1080\/14659891.2016.1235734","article-title":"Jordanian community pharmacists\u2019 experience regarding prescription and nonprescription drug abuse and misuse in Jordan\u2013An update","volume":"22","author":"Wazaify","year":"2017","journal-title":"J. Subst. Use"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/qjmed\/hcz215","article-title":"Nonmedical use of loperamide in the UK and the USA","volume":"113","author":"Webb","year":"2020","journal-title":"QJM Int. J. Med."},{"key":"ref_22","unstructured":"United Nation Office of Drugs and Crime (UNDC) (2022). World Drug Report, Executive Summary Policy Implications, UNDC."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Chung, C.-H., Lin, I.-J., Huang, Y.-C., Sun, C.-A., Chien, W.-C., and Tzeng, N.-S. (2023). The association between abused adults and substance abuse in Taiwan, 2000\u20132015. BMC Psychiatry, 23.","DOI":"10.1186\/s12888-023-04608-z"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.drugalcdep.2012.11.003","article-title":"\u201cI just wanted to tell you that loperamide WILL WORK\u201d: A web-based study of extra-medical use of loperamide","volume":"130","author":"Daniulaityte","year":"2013","journal-title":"Drug Alcohol Depend."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/fampra\/cmp105","article-title":"Consumer habits and interests regarding non-prescription medications in Hungary","volume":"27","author":"Major","year":"2010","journal-title":"Fam. Pract."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/IPRP.S103494","article-title":"Abuse of over-the-counter medicines: A pharmacist\u2019s perspective","volume":"6","author":"Sansgiry","year":"2016","journal-title":"Integr. Pharm. Res. Pract."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1517\/14740338.2.1.1","article-title":"Monitoring self-medication","volume":"2","author":"Hughes","year":"2003","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_28","first-page":"313","article-title":"Misuse of over-the-counter medicines: A survey in one English county","volume":"256","author":"Paxton","year":"1996","journal-title":"Pharm. J."},{"key":"ref_29","first-page":"S20","article-title":"E-pharmacy: Improving patient care and managing risk","volume":"42","author":"Bates","year":"2002","journal-title":"J. Am. Pharm. Assoc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/NHH.0000000000000871","article-title":"Dangerous Abuse of a 40-Year-Old Over-the-Counter Medication, Loperamide","volume":"38","author":"Shastay","year":"2020","journal-title":"Home Healthc. Now"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00228-004-0815-3","article-title":"Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes","volume":"60","author":"Kim","year":"2004","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e12508","DOI":"10.1111\/anec.12508","article-title":"Efficacy and safety of intravenous vernakalant for the rapid conversion of recent-onset atrial fibrillation: A meta-analysis","volume":"23","author":"Akel","year":"2018","journal-title":"Ann. Noninvasive Electrocardiol."},{"key":"ref_33","first-page":"e6314","article-title":"A Rising Concern of Loperamide Abuse: A Case Report on Resulting Cardiac Complications","volume":"11","author":"Sapra","year":"2019","journal-title":"Cureus"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/ajhp\/zxy089","article-title":"The opioid crisis: Origins, trends, policies, and the roles of pharmacists","volume":"76","author":"Spivey","year":"2019","journal-title":"Am. J. Health-Syst. Pharm."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/14\/6400\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:14:53Z","timestamp":1760127293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/20\/14\/6400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,19]]},"references-count":34,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["ijerph20146400"],"URL":"https:\/\/doi.org\/10.3390\/ijerph20146400","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,19]]}}}