{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T07:38:28Z","timestamp":1775979508189,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","award":["ANRS-0154"],"award-info":[{"award-number":["ANRS-0154"]}]},{"name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","award":["ANRS-0174"],"award-info":[{"award-number":["ANRS-0174"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>(1) Background: A substantial proportion of COVID-19 patients continue to experience long-lasting effects that hamper their quality of life. The objectives of this study were (1) to report the prevalence of persistent clinical symptoms 6\u201312 months after the onset of COVID-19 and (2) to identify potential factors at admission associated with the occurrence of long COVID. (2) Methods: A prospective study was conducted among COVID-19 adult patients, hospitalized in four French university hospitals. Patients were invited to two ambulatory follow-up medical visits, 6\u20138 months (visit #1) and one year (visit #2) after the onset of their COVID-19. A multivariate logistic regression was performed to assess factors associated with long COVID. (3) Results: In total, 189 patients participated in this study (mean age of 63.4 years). BMI &gt; 30 kg\/m2 (aOR 3.52), AST levels between 31 and 42 U\/L (aOR 8.68), and AST levels &gt; 42 U\/L (aOR 3.69) were associated with persistent clinical symptoms at visit #1. Anosmia (aOR 13.34), AST levels between 31 and 42 U\/L (aOR 10.27), stay in ICU (aOR 5.43), pain (aOR 4.31), and longer time before hospitalization (aOR 1.14) were significantly associated with persistent clinical symptoms at visit #2. Patients with ageusia (aOR 0.17) had a lower risk of long COVID. (4) Conclusions: This study showed that some patients experienced persistent clinical symptoms one year after COVID-19 onset that were associated with some determinants at the acute phase\/stage.<\/jats:p>","DOI":"10.3390\/ijerph20176678","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T10:30:52Z","timestamp":1693391452000},"page":"6678","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Factors Associated with Long COVID-19 in a French Multicentric Prospective Cohort Study"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6455-238X","authenticated-orcid":false,"given":"Nagham","family":"Khanafer","sequence":"first","affiliation":[{"name":"Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS UMR5308, ENS de Lyon, Lyon 1 University, CEDEX 07, 69364 Lyon, France"},{"name":"Department of Hygiene, Epidemiology, and Prevention, Edouard Herriot Hospital, Hospices Civils de Lyon, 69003 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laetitia","family":"Henaff","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS UMR5308, ENS de Lyon, Lyon 1 University, CEDEX 07, 69364 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Bennia","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology, and Prevention, Edouard Herriot Hospital, Hospices Civils de Lyon, 69003 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Termoz","sequence":"additional","affiliation":[{"name":"Service Recherche et Epid\u00e9miologie Cliniques, Hospices Civils de Lyon, P\u00f4le Sant\u00e9 Publique, 69003 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Chapurlat","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Edouard Herriot University Hospital, Hospices Civils de Lyon, 69003 Lyon, France"},{"name":"INSERM UMR 1033, University of Lyon, 69003 Lyon, France"},{"name":"Pr\u00e9vention des Maladies Osseuses, Edouard Herriot Hospital, Hospices Civils de Lyon, 69003 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5298-1002","authenticated-orcid":false,"given":"Vanessa","family":"Escuret","sequence":"additional","affiliation":[{"name":"Institut des Agents Infectieux, Hospices Civils de Lyon, 69317 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Proriol","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Edouard Herriot University Hospital, Hospices Civils de Lyon, 69003 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Duvert","sequence":"additional","affiliation":[{"name":"INSERM UMR 1033, University of Lyon, 69003 Lyon, France"},{"name":"Pr\u00e9vention des Maladies Osseuses, Edouard Herriot Hospital, Hospices Civils de Lyon, 69003 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Mena","sequence":"additional","affiliation":[{"name":"INSERM UMR 1033, University of Lyon, 69003 Lyon, France"},{"name":"Pr\u00e9vention des Maladies Osseuses, Edouard Herriot Hospital, Hospices Civils de Lyon, 69003 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Planckaert","sequence":"additional","affiliation":[{"name":"INSERM UMR 1033, University of Lyon, 69003 Lyon, France"},{"name":"Pr\u00e9vention des Maladies Osseuses, Edouard Herriot Hospital, Hospices Civils de Lyon, 69003 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nad\u00e8ge","family":"Trehet-Mandez","sequence":"additional","affiliation":[{"name":"INSERM UMR 1033, University of Lyon, 69003 Lyon, France"},{"name":"Pr\u00e9vention des Maladies Osseuses, Edouard Herriot Hospital, Hospices Civils de Lyon, 69003 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitra","family":"Saadatian-Elahi","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS UMR5308, ENS de Lyon, Lyon 1 University, CEDEX 07, 69364 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Vanhems","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS UMR5308, ENS de Lyon, Lyon 1 University, CEDEX 07, 69364 Lyon, France"},{"name":"Department of Hygiene, Epidemiology, and Prevention, Edouard Herriot Hospital, Hospices Civils de Lyon, 69003 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41591-021-01292-y","article-title":"Attributes and predictors of long COVID","volume":"27","author":"Sudre","year":"2021","journal-title":"Nat. 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