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Therefore, they are usually treated with an assistive device, a so-called ankle\u2013foot orthosis. The support of the orthosis should be in accordance with the motor requirements of the patient and should only be provided when needed, which is referred to as assistance-as-needed. Thus, in this publication, an approach is presented to determine the assistance-as-needed support using musculoskeletal human models. Based on motion capture recordings of multiple subjects performing gaits at different speeds, a parameter study varying the optimal force of a reserve actuator representing the ankle\u2013foot orthosis added in the musculoskeletal simulation is conducted. The results show the dependency of the simulation results on the selected optimal force of the reserve actuator but with a possible identification of the assistance-as-needed support required from the ankle\u2013foot orthosis. The required increase in support due to the increasing severity of foot drop is especially demonstrated with the approach. With this approach, information for the required support of individual subjects can be gathered, which can further be used to derive the design of an ankle\u2013foot orthosis that optimally assists the subjects.<\/jats:p>","DOI":"10.3390\/ijerph20176687","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T11:45:51Z","timestamp":1693482351000},"page":"6687","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Determination of Assistance-as-Needed Support by an Ankle\u2013Foot Orthosis for Patients with Foot Drop"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9618-2942","authenticated-orcid":false,"given":"David","family":"Scherb","sequence":"first","affiliation":[{"name":"Engineering Design, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5213-8800","authenticated-orcid":false,"given":"Patrick","family":"Steck","sequence":"additional","affiliation":[{"name":"Engineering Design, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5855-3765","authenticated-orcid":false,"given":"Iris","family":"Wechsler","sequence":"additional","affiliation":[{"name":"Engineering Design, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0244-5033","authenticated-orcid":false,"given":"Sandro","family":"Wartzack","sequence":"additional","affiliation":[{"name":"Engineering Design, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8610-1966","authenticated-orcid":false,"given":"J\u00f6rg","family":"Miehling","sequence":"additional","affiliation":[{"name":"Engineering Design, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"key":"ref_1","first-page":"CD003908","article-title":"Rehabilitation interventions for foot drop in neuromuscular disease","volume":"3","author":"Sackley","year":"2009","journal-title":"Cochrane Database Syst. 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