{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:53:28Z","timestamp":1785513208828,"version":"3.56.0"},"reference-count":34,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dong-A University research fund","award":["DAUHIRB-19-190"],"award-info":[{"award-number":["DAUHIRB-19-190"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Patients with mild cognitive impairment (MCI) have a relatively high risk of developing Alzheimer\u2019s dementia (AD), so early identification of the risk for AD conversion can lessen the socioeconomic burden. In this study, 18F-Florapronol, newly developed in Korea, was used for qualitative and quantitative analyses to assess amyloid positivity. We also investigated the clinical predictors of the progression from MCI to dementia over 2 years. From December 2019 to December 2022, 50 patients with MCI were recruited at a single center, and 34 patients were included finally. Based on visual analysis, 13 (38.2%) of 34 participants were amyloid-positive, and 12 (35.3%) were positive by quantitative analysis. Moreover, 6 of 34 participants (17.6%) converted to dementia after a 2-year follow-up (p = 0.173). Among the 15 participants who were positive for amyloid in the posterior cingulate region, 5 (33.3%) patients developed dementia (p = 0.066). The Clinical Dementia Rating-Sum of Boxes (CDR-SOB) at baseline was significantly associated with AD conversion in multivariate Cox regression analyses (p = 0.043). In conclusion, these results suggest that amyloid positivity in the posterior cingulate region and higher CDR-SOB scores at baseline can be useful predictors of AD conversion in patients with MCI.<\/jats:p>","DOI":"10.3390\/ijerph21050547","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T08:18:27Z","timestamp":1714119507000},"page":"547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and Neuroimaging Predictors of Alzheimer\u2019s Dementia Conversion in Patients with Mild Cognitive Impairment Using Amyloid Positron Emission Tomography by Quantitative Analysis over 2 Years"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9251-2932","authenticated-orcid":false,"given":"Seonjeong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology, Cognitive Disorders and Dementia Center, Dong-A University College of Medicine, Busan 49201, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daye","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cognitive Disorders and Dementia Center, Dong-A University College of Medicine, Busan 49201, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8082-3566","authenticated-orcid":false,"given":"Junho","family":"Seong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cognitive Disorders and Dementia Center, Dong-A University College of Medicine, Busan 49201, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-8185","authenticated-orcid":false,"given":"Young Jin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Dong-A University College of Medicine, Busan 49201, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-0818","authenticated-orcid":false,"given":"Do-Young","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Dong-A University College of Medicine, Busan 49201, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6788-5267","authenticated-orcid":false,"given":"Kyung Won","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cognitive Disorders and Dementia Center, Dong-A University College of Medicine, Busan 49201, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1212\/01.wnl.0000228244.10416.20","article-title":"Mild cognitive impairment: Risk of Alzheimer disease and rate of cognitive decline","volume":"67","author":"Boyle","year":"2006","journal-title":"Neurology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1006\/exnr.1999.7086","article-title":"Entorhinal cortex beta-amyloid load in individuals with mild cognitive impairment","volume":"158","author":"Mufson","year":"1999","journal-title":"Exp. 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