{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:09:26Z","timestamp":1760144966421,"version":"build-2065373602"},"reference-count":45,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["001","01284\/17"],"award-info":[{"award-number":["001","01284\/17"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FAPEMA","award":["001","01284\/17"],"award-info":[{"award-number":["001","01284\/17"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The hypothesis that physiological changes in women can affect periodontal tissues is the subject of this study, and inflammatory markers such as matrix metalloproteinase-8 can measure susceptibility to inflammation. The study aimed to analyze MMP-8 levels in periodontal sites of postpartum women and women without a history of pregnancy, comparing health parameters and periodontal disease. This is a case\u2013control study with 40 participants, 20 cases (women in the postpartum period) and 20 controls (women without any pregnancy), who underwent clinical periodontal examination and the collection of crevicular gingival fluid. The ELISA test was used to detect MMP-8 levels. Postpartum women had worse periodontal parameters, such as bleeding index on probing, number of sites with CAL \u2265 3, and fewer teeth present. In the group of women without a history of pregnancy, a significantly lower MMP-8 level was observed in healthy sites and a higher one was observed in periodontal pockets (p &lt; 0.01). In contrast, in postpartum women, MMP-8 levels were elevated in both healthy sites and periodontal pockets (p &gt; 0.01). The MMP-8 levels in gingival fluid appear to be related to periodontal clinical parameters and may be a possible marker of enzymatic changes involved in periodontal tissue destruction in postpartum women.<\/jats:p>","DOI":"10.3390\/ijerph21060739","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T06:40:26Z","timestamp":1717656026000},"page":"739","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MMP-8 in Periodontal Sites of Postpartum and without-Any-Pregnancy Women"],"prefix":"10.3390","volume":"21","author":[{"given":"Karyne Martins","family":"Lima","sequence":"first","affiliation":[{"name":"Postgraduate Program in Dentistry, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds CEP 65080-805, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko Aramaki Abreu","family":"Calado","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Adult Health, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds CEP 65080-805, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana de F\u00e1tima Vasconcelos","family":"Pereira","sequence":"additional","affiliation":[{"name":"Teacher of the Department of Dentistry II, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds CEP 65080-805, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1868-6931","authenticated-orcid":false,"given":"Mayara Cristina Pinto da","family":"Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Adult Health, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds CEP 65080-805, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5818-412X","authenticated-orcid":false,"given":"Fernanda Ferreira","family":"Lopes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds CEP 65080-805, Brazil"},{"name":"Postgraduate Program in Adult Health, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds CEP 65080-805, Brazil"},{"name":"Teacher of the Department of Dentistry II, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds CEP 65080-805, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3389\/fimmu.2017.00139","article-title":"Role of Maternal Periodontitis in Preterm Birth","volume":"8","author":"Ren","year":"2017","journal-title":"Front. 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