{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:16:40Z","timestamp":1792617400067,"version":"4.5.0"},"reference-count":38,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Raynaud\u2019s phenomenon of the nipple is a possible cause of pain and breastfeeding cessation in lactating women. However, there are still few studies on the characterization of this manifestation. Thus, we aim to develop a systematic review of the literature carried out between January 1992 and January 2024 in PubMed, Scopus, Web of Science, Virtual Health Library (VHL), and Portal de Peri\u00f3dicos da CAPES. Of the 438 articles, 19 met the eligibility criteria. The findings were divided by heuristic questions into two groups: \u201cEpidemiological, pathophysiological, and clinical characterization of Raynaud\u2019s Phenomenon of the nipple\u201d and \u201cTreatment of Raynaud\u2019s Phenomenon of the nipple\u201d. Raynaud\u2019s phenomenon of the nipple is commonly primary, being more prevalent in the postpartum period, in women with a mean age of 32 years. The main triggers appear to be stress and temperature change. Generally, it is associated with a change in color and pain during breastfeeding. A calcium channel blocker was the most used medication with or without non-pharmacological measures.<\/jats:p>","DOI":"10.3390\/ijerph21070849","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T06:04:18Z","timestamp":1719986658000},"page":"849","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Raynaud\u2019s Phenomenon of the Nipple: Epidemiological, Clinical, Pathophysiological, and Therapeutic Characterization"],"prefix":"10.3390","volume":"21","author":[{"given":"Tha\u00eds Gomes","family":"Moreira","sequence":"first","affiliation":[{"name":"School of Medicine, Universidade Federal do Cariri (UFCA), Barbalha 63048-080, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana Mamede","family":"Castro","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidade Federal do Cariri (UFCA), Barbalha 63048-080, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5077-7959","authenticated-orcid":false,"given":"Jucier","family":"Gon\u00e7alves J\u00fanior","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidade Federal do Cariri (UFCA), Barbalha 63048-080, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"658","DOI":"10.12968\/hmed.2019.80.11.658","article-title":"Raynaud\u2019s Phenomenon","volume":"80","author":"Devgire","year":"2019","journal-title":"Br. 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