{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:23:23Z","timestamp":1783052603207,"version":"3.54.6"},"reference-count":56,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007393","name":"AFM-Telethon","doi-asserted-by":"publisher","award":["24420"],"award-info":[{"award-number":["24420"]}],"id":[{"id":"10.13039\/100007393","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Facioscapulohumeral dystrophy (FSHD) leads to progressive changes in body composition such as loss of muscle mass and increase in adiposity. In healthy subjects, anthropometric parameters are associated with the maximum volume of oxygen consumed per minute (VO2max), which is a health and function indicator in several populations of subjects, both healthy and pathological. Since VO2max can be difficult to test in patients with FSHD due to exercise intolerance, the identification of associated anthropometric parameters could provide new easily obtainable elements for the patients\u2019 clinical stratification. The aim of this study was to evaluate whether anthropometric and body composition parameters are associated with VO2max in patients with FSHD. A total of 22 subjects with a molecular genetics-based diagnosis of FSHD (6 females, 16 males, mean age of 35.18 years) were recruited for the study. VO2max was measured by cardiopulmonary exercise tests (CPETs) on a cycle ergometer, utilizing a step incremental technique (15 Watts (W) every 30 s). Weight (Kg) and height (m) were obtained and utilized to calculate body mass index (BMI). Body composition parameters (fat mass (FM), fat free mass (FFM), and body cell mass (BCM)) were obtained by bioelectrical impedance analysis (BIA). Significant negative associations were found between VO2max and FM (Spearman correlation coefficient (SCC) \u22120.712), BMI (SCC \u22120.673), age (SCC \u22120.480), and weight (SCC \u22120.634), unlike FFM and BCM. Our results indicate that FM, BMI, age, and body weight are negatively associated with VO2max in patients with FSHD. This evidence may help practitioners to better stratify patients with FSHD.<\/jats:p>","DOI":"10.3390\/ijerph21080979","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T09:22:42Z","timestamp":1721985762000},"page":"979","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Maximal Oxygen Consumption Is Negatively Associated with Fat Mass in Facioscapulohumeral Dystrophy"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8586-6465","authenticated-orcid":false,"given":"Oscar","family":"Crisafulli","sequence":"first","affiliation":[{"name":"CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058 Voghera, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Grattarola","sequence":"additional","affiliation":[{"name":"CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058 Voghera, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Bottoni","sequence":"additional","affiliation":[{"name":"CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058 Voghera, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Lacetera","sequence":"additional","affiliation":[{"name":"CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058 Voghera, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Lavaselli","sequence":"additional","affiliation":[{"name":"CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058 Voghera, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Beretta-Piccoli","sequence":"additional","affiliation":[{"name":"CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058 Voghera, Italy"},{"name":"Rehabilitation Research Laboratory 2rLab, Department of Business Economics, Health and Social Care, University of Applied Sciences and Arts of Southern Switzerland, 6928 Manno, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Tupler","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9577-5567","authenticated-orcid":false,"given":"Emiliano","family":"Soldini","sequence":"additional","affiliation":[{"name":"Competence Centre for Healthcare Practices and Policies, Department of Business Economics, Health and Social Care, University of Applied Sciences and Arts of Southern Switzerland, 6928 Manno, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-5565","authenticated-orcid":false,"given":"Giuseppe","family":"D\u2019Antona","sequence":"additional","affiliation":[{"name":"CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058 Voghera, Italy"},{"name":"Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27058 Voghera, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5152\/TurkJOrthod.2021.21021","article-title":"Orofacial Manifestations Associated with Muscular Dystrophies: A Review","volume":"35","author":"Papaefthymiou","year":"2022","journal-title":"Turk. 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