{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:21:48Z","timestamp":1760145708160,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T00:00:00Z","timestamp":1724544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health National Heart Lung and Blood","award":["R00 HL164888"],"award-info":[{"award-number":["R00 HL164888"]}]},{"name":"the American Society of Hematology Scholar Award","award":["R00 HL164888"],"award-info":[{"award-number":["R00 HL164888"]}]},{"name":"the Eleanor and Miles Shore Faculty Development Award","award":["R00 HL164888"],"award-info":[{"award-number":["R00 HL164888"]}]},{"name":"Foundation for Women\u2019s Wellness","award":["R00 HL164888"],"award-info":[{"award-number":["R00 HL164888"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Chronic exposure to severe hypoxia causes an increase in hematocrit (Hct) and hemoglobin concentration ([Hb]), which can lead to excessive erythrocytosis (EE) and impact physical performance. This work aims to determine the differences in the six-minute walking test (6MWT) between EE and healthy subjects residing at more than 5000 m. Methods: A prospective, cross-sectional study was performed on 71 men (36 healthy and 25 suffering from EE) living in La Rinconada, Peru (5100 m). Basal levels of [Hb] and Hct were obtained. All the subjects performed the 6MWT, and distance reached, vital signs, dyspnea, and fatigue (Borg scale) at the end of the test were recorded. Results: The average [Hb] and Hct levels in the control group were 18.7 \u00b1 1.2 g\/dL and 60.4 \u00b1 7.1%, respectively, contrasting with EE subjects, who showed 23.4 \u00b1 1.6 g\/dL and 73.6 \u00b1 5.9% (p &lt; 0.001). However, no statistically significant differences were observed in BMI or other anthropometric parameters. At the end of the 6MWT, the distance traveled and vital constants were similar between both groups, except for arterial oxygen saturation, which was consistently lower in subjects with EE throughout the test. Conclusion: EE does not significantly affect 6MWT performance at high altitudes, nor the hemodynamic control during moderate aerobic exercise of subjects who live permanently in a severely hypoxic environment.<\/jats:p>","DOI":"10.3390\/ijerph21091119","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T01:48:49Z","timestamp":1724636929000},"page":"1119","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Performance in the Six-Minute Walking Test Does Not Discriminate Excessive Erythrocytosis Patients in a Severe Hypoxic Environment"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2475-2998","authenticated-orcid":false,"given":"Rossela Alejandra","family":"Rojas-Chambilla","sequence":"first","affiliation":[{"name":"Facultad de Medicina Humana, Universidad Nacional del Altiplano, Puno 21000, Peru"},{"name":"Asociaci\u00f3n Cient\u00edfica de Estudiantes de Medicina (ACEM), Puno 21000, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kely Melina","family":"Vilca-Coaquira","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Humana, Universidad Nacional del Altiplano, Puno 21000, Peru"},{"name":"Asociaci\u00f3n Cient\u00edfica de Estudiantes de Medicina (ACEM), Puno 21000, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9037-131X","authenticated-orcid":false,"given":"Jeancarlo","family":"Tejada-Flores","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Humana, Universidad Nacional del Altiplano, Puno 21000, Peru"},{"name":"Asociaci\u00f3n Cient\u00edfica de Estudiantes de Medicina (ACEM), Puno 21000, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5516-3235","authenticated-orcid":false,"given":"Henry Oscar","family":"Tintaya-Ramos","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Humana, Universidad Nacional del Altiplano, Puno 21000, Peru"},{"name":"Asociaci\u00f3n Cient\u00edfica de Estudiantes de Medicina (ACEM), Puno 21000, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariela Mercedes","family":"Quispe-Trujillo","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Humana, Universidad Nacional del Altiplano, Puno 21000, Peru"},{"name":"Asociaci\u00f3n Cient\u00edfica de Estudiantes de Medicina (ACEM), Puno 21000, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel Gabriel","family":"Calisaya-Huacasi","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Humana, Universidad Nacional del Altiplano, Puno 21000, Peru"},{"name":"Asociaci\u00f3n Cient\u00edfica de Estudiantes de Medicina (ACEM), Puno 21000, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solanyela Anny","family":"Quispe-Humpiri","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Humana, Universidad Nacional del Altiplano, Puno 21000, Peru"},{"name":"Asociaci\u00f3n Cient\u00edfica de Estudiantes de Medicina (ACEM), Puno 21000, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yony Martin","family":"Pino-Vanegas","sequence":"additional","affiliation":[{"name":"Escuela Profesional de Educaci\u00f3n F\u00edsica, Facultad de Ciencias de la Educaci\u00f3n, Universidad Nacional del Altiplano, Puno 21000, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Alcibiades","family":"Salazar-Granara","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Medicina de Altura (CIMA), Facultad de Medicina Humana, Universidad de San Mart\u00edn de Porres, Lima 15024, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Luc\u00eda","family":"T\u00e1cuna-Calder\u00f3n","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Medicina de Altura (CIMA), Facultad de Medicina Humana, Universidad de San Mart\u00edn de Porres, Lima 15024, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy M\u00f3nica","family":"Garc\u00eda-Bedoya","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Medicina de Altura (CIMA), Facultad de Medicina Humana, Universidad de San Mart\u00edn de Porres, Lima 15024, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6340-457X","authenticated-orcid":false,"given":"Moua","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA"},{"name":"Bloodworks Northwest Research Institute, Seattle, WA 98102, USA"},{"name":"Division of Hematology and Oncology, Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98102, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4942-2346","authenticated-orcid":false,"given":"Gin\u00e9s","family":"Viscor","sequence":"additional","affiliation":[{"name":"Secci\u00f3 de Fisiologia, Departament de Biologia Cel\u00b7lular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona, E-08028 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"Hancco-Zirena","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Medicina de Altura (CIMA), Facultad de Medicina Humana, Universidad de San Mart\u00edn de Porres, Lima 15024, Peru"},{"name":"Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sydykov, A., Mamazhakypov, A., Maripov, A., Kosanovic, D., Weissmann, N., Ghofrani, H.A., Sarybaev, A.S., and Schermuly, R.T. 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