{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:08:10Z","timestamp":1778054890817,"version":"3.51.4"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination for the Advancement of Higher Education Staff (CAPES)","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordination for the Advancement of Higher Education Staff (CAPES)","doi-asserted-by":"publisher","award":["25052 Fapemig\/FO\/OPO\/Osteogenese"],"award-info":[{"award-number":["25052 Fapemig\/FO\/OPO\/Osteogenese"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State of Minas Gerais Research Support Foundation (FAPEMIG)","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"State of Minas Gerais Research Support Foundation (FAPEMIG)","award":["25052 Fapemig\/FO\/OPO\/Osteogenese"],"award-info":[{"award-number":["25052 Fapemig\/FO\/OPO\/Osteogenese"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The present study aimed to compare the prevalence of oral problems between individuals with rare genetic diseases that affect skeletal development and individuals without rare diseases. A cross-sectional study was conducted with 210 individuals between two and fifty-four years of age: 105 with rare genetic diseases (27 with mucopolysaccharidosis [MPS] and 78 with osteogenesis imperfecta [OI]) and 105 without rare diseases. The rare genetic disease group was recruited from hospital units that provide care for patients with MPS and OI in five states of Brazil, and the other group was recruited from the same location. The participants were examined with regards to malocclusion, dental anomalies, dental caries, and gingivitis. A questionnaire was administered addressing individual, sociodemographic, and behavioral characteristics as well as dental history. A descriptive analysis was performed, followed by unadjusted and adjusted binary logistic regression analyses. The mean age was 14.1 \u00b1 12.2 years. Individuals with a rare disease were 12.9-fold more likely to have some type of oral problem (95% CI: 3.7\u201344.7) compared to the group without rare diseases. The prevalence of oral problems was higher among Brazilians with MPS and OI compared to normotypical individuals.<\/jats:p>","DOI":"10.3390\/ijerph21091227","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T09:43:13Z","timestamp":1726652593000},"page":"1227","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oral Problems in Brazilian Individuals with Rare Genetic Diseases That Affect Skeletal Development"],"prefix":"10.3390","volume":"21","author":[{"given":"Flavia","family":"Rabello","sequence":"first","affiliation":[{"name":"Undergraduate Course in Dentistry, Pontifical Catholic University of Minas Gerais, Belo Horizonte 30535-500, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana La\u00eds Silva","family":"Celestino","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-800, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia Cristina Ruy","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-800, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6040-8935","authenticated-orcid":false,"given":"Jennifer","family":"Reis-Oliveira","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-800, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9061-5644","authenticated-orcid":false,"given":"Helo\u00edsa Vieira","family":"Prado","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-800, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8794-5725","authenticated-orcid":false,"given":"Mauro Henrique Nogueira Guimar\u00e3es de","family":"Abreu","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-800, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina","family":"Borges-Oliveira","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-800, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization\u2014WHO (2024, May 17). 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