{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:24:40Z","timestamp":1791635080876,"version":"4.3.4"},"reference-count":17,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020648","name":"Santa Cruz State University (UESC)","doi-asserted-by":"publisher","award":["073.11006.2021.0022720-16"],"award-info":[{"award-number":["073.11006.2021.0022720-16"]}],"id":[{"id":"10.13039\/501100020648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Sickle cell disease (SCD) presents complex clinical manifestations influenced by genetic, social, environmental, and healthcare access factors as well as socioeconomic status. In this context, sickle cell leg ulcers (SLUs) are a debilitating complication of SCD. We aimed to describe sociodemographic data and evaluate the quality of life (QoL) of SCD patients with and without SLUs. We conducted a cross-sectional study including 13 SCD patients with SLUs and 42 without LUs. Clinical data were obtained by reviewing the medical records, and QoL was assessed with the WHOQOL-BREF questionnaire. Our cohort of patients had a mean age of 34.9 years, with 52.8% male, 52.8% identifying as black, and 41.7% identifying as brown. Most had low income, incomplete education, and high unemployment rates. The social habits and relationships of SCD patients showed varying levels of friendship and family closeness, and the majority of SLU+ patients did not practice sports. We failed to find statistical differences in the WHOQOL-BREF domains between SLU+ and SLU\u2212 patients. However, higher income and employment status were associated with improved WHOQOL-BREF domain scores in SCD patients, while vaso-occlusive episodes and female gender were linked to lower scores. Our data reinforce the sociodemographic characteristics of SCD. The physical domain was associated with income, occupation, and vaso-occlusion. The psychological domain was associated with income and occupation. The social relationship domain was associated with occupation and female gender. The environmental domain was associated with vaso-occlusion. The WHOQOL-BREF is a reliable tool to measure QoL in SCD.<\/jats:p>","DOI":"10.3390\/ijerph22010108","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T04:42:08Z","timestamp":1736916128000},"page":"108","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["WHOQOL-BREF in Measuring Quality of Life Among Sickle Cell Disease Patients with Leg Ulcers"],"prefix":"10.3390","volume":"22","author":[{"given":"Caroline Concei\u00e7\u00e3o","family":"da Guarda","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Patologia Aplicada e Gen\u00e9tica, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Santa Cruz, Ilh\u00e9us 45662-900, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4915-3165","authenticated-orcid":false,"given":"J\u00e9ssica Eut\u00edmio","family":"de Carvalho Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Patologia Aplicada e Gen\u00e9tica, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Santa Cruz, Ilh\u00e9us 45662-900, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Imbassahy Valentim","family":"Melo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Patologia Aplicada e Gen\u00e9tica, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Santa Cruz, Ilh\u00e9us 45662-900, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Vin\u00edcius Bispo","family":"Santana","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Patologia Aplicada e Gen\u00e9tica, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Santa Cruz, Ilh\u00e9us 45662-900, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elis\u00e2ngela Vit\u00f3ria","family":"Adorno","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Anemias, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade Federal da Bahia, Salvador 40170-115, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Spier","sequence":"additional","affiliation":[{"name":"Centro de Refer\u00eancia em Doen\u00e7a Falciforme, Secretaria Municipal de Sa\u00fade de Itabuna, Itabuna 45600-075, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa Cristina Cardoso","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias da Sa\u00fade, Universidade Estadual de Santa Cruz, Ilh\u00e9us 45662-900, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilda 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