{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:44:46Z","timestamp":1759970686275,"version":"build-2065373602"},"reference-count":73,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss Federal Office of Public Health"},{"name":"General Directorate of Health of the Department of Safety, Employment and Health of the canton of Geneva"},{"name":"Private Foundation of the Geneva University Hospitals"},{"name":"Swiss School of Public Health"},{"name":"Fondation des Grangettes"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: The post-acute impact of SARS-CoV-2 infections on chronic conditions remains poorly understood, particularly in general populations. Objectives: Our primary aim was to assess the association between SARS-CoV-2 infections and new diagnoses of chronic conditions. Our two secondary aims were to explore geographic variations in this association and to assess the association between SARS-CoV-2 infections and the exacerbation of pre-existing conditions. Methods: This longitudinal study used data from 8086 participants of the Specchio-COVID-19 cohort in the canton of Geneva, Switzerland (2021\u20132023). Mixed-effects logistic regressions and geographically weighted regressions adjusted for sociodemographic, socioeconomic, and healthcare access covariates were used to analyze self-reported SARS-CoV-2 infections, new diagnoses of chronic conditions, and the exacerbation of pre-existing ones. Results: Participants reporting a SARS-CoV-2 infection were more likely to be diagnosed with a new chronic condition compared to those who did not report an infection (adjusted odds ratio [aOR] = 2.15, 95% CI 1.43\u20133.23, adjusted p-value = 0.002). Notable geographic variations were identified in the association between SARS-CoV-2 infections and new diagnoses. While a positive association was initially observed between SARS-CoV-2 infections and exacerbation of pre-existing chronic conditions, this association did not remain significant after adjusting p-values for multiple comparisons. Conclusions: These findings contribute to understanding COVID-19\u2019s post-acute impact on chronic conditions, highlighting the need for targeted health management approaches and calling for tailored public health strategies to address the pandemic\u2019s long-term effects.<\/jats:p>","DOI":"10.3390\/ijerph22020166","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T04:59:10Z","timestamp":1737953950000},"page":"166","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SARS-CoV-2 Infection and the Risk of New Chronic Conditions: Insights from a Longitudinal Population-Based Study"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6462-2501","authenticated-orcid":false,"given":"David","family":"De Ridder","sequence":"first","affiliation":[{"name":"Geographic Information Research and Analysis in Population Health (GIRAPH) Lab, Department of Community Health and Medicine, Faculty of Medicine, 1205 Geneva, Switzerland"},{"name":"Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anshu","family":"Uppal","sequence":"additional","affiliation":[{"name":"Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serguei","family":"Rouzinov","sequence":"additional","affiliation":[{"name":"Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3129-1974","authenticated-orcid":false,"given":"Julien","family":"Lamour","sequence":"additional","affiliation":[{"name":"Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda-Eugenia","family":"Zaballa","sequence":"additional","affiliation":[{"name":"Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Baysson","sequence":"additional","affiliation":[{"name":"Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1184-7501","authenticated-orcid":false,"given":"St\u00e9phane","family":"Joost","sequence":"additional","affiliation":[{"name":"Geographic Information Research and Analysis in Population Health (GIRAPH) Lab, Department of Community Health and Medicine, Faculty of Medicine, 1205 Geneva, Switzerland"},{"name":"Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Geospatial Molecular Epidemiology (GEOME), Laboratory for Biological Geochemistry (LGB), School of Architecture, Civil and Environmental Engineering (ENAC), \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1015 Lausanne, Switzerland"},{"name":"La Source School of Nursing, University of Applied Sciences and Arts Western Switzerland (HES-SO), 1004 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Stringhini","sequence":"additional","affiliation":[{"name":"Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"School of Population and Public Health, and Edwin S.H, Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"},{"name":"Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idris","family":"Guessous","sequence":"additional","affiliation":[{"name":"Geographic Information Research and Analysis in Population Health (GIRAPH) Lab, Department of Community Health and Medicine, Faculty of Medicine, 1205 Geneva, Switzerland"},{"name":"Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayssam","family":"Nehme","sequence":"additional","affiliation":[{"name":"Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, 1205 Geneva, 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