{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:47:11Z","timestamp":1768265231301,"version":"3.49.0"},"reference-count":47,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Novo Nordic Foundations Pre Graduate Scholarships","award":["NNF18OC0053080"],"award-info":[{"award-number":["NNF18OC0053080"]}]},{"name":"Novo Nordic Foundations Pre Graduate Scholarships","award":["948"],"award-info":[{"award-number":["948"]}]},{"name":"\u201cFolkesundhed I Midten\u201d Foundation","award":["NNF18OC0053080"],"award-info":[{"award-number":["NNF18OC0053080"]}]},{"name":"\u201cFolkesundhed I Midten\u201d Foundation","award":["948"],"award-info":[{"award-number":["948"]}]},{"name":"Kerrn-Jespersen Foundation","award":["NNF18OC0053080"],"award-info":[{"award-number":["NNF18OC0053080"]}]},{"name":"Kerrn-Jespersen Foundation","award":["948"],"award-info":[{"award-number":["948"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Refugees have different disease patterns than the population in receiving countries. Furthermore, refugees face barriers to accessing health care services and treatment. The purpose of this study was to describe the prevalence of eosinophilia and elevated IgE levels in refugees and assess the clinical follow-up. Using a cross-sectional study design, we offered health assessments, including eosinophil count and IgE level measurements, to all newly arrived refugees in a Danish municipality from January 2016 to November 2018. In a subgroup, we assessed the clinical follow-up. The study population consisted of 793 refugees, all of whom had eosinophil counts measured, with 411 also having IgE levels measured. Notably, 48.6% were female and most participants originated from Syria, Eritrea, Iran or Afghanistan, with smaller representation from several other countries. Notably, 6.8% had eosinophilia and 32.1% had elevated IgE levels. Syrian origin was associated with a lower prevalence of both biomarkers, and Eritrean origin with a higher prevalence. In a subgroup of 116 participants with abnormal results, general practitioners brought attention to the elevated levels in 50.9% of the cases, and 31.0% of these received a diagnosis related to the findings. In total, 98.3% (114) of patients in the subgroup had contact with their GP following the health assessment. In refugees, eosinophilia and elevated IgE levels are common conditions, and underlying causes are often not diagnosed, potentially leading to inadequate treatment and worse health outcomes.<\/jats:p>","DOI":"10.3390\/ijerph22020180","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T06:47:29Z","timestamp":1738046849000},"page":"180","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["IgE and Eosinophilia in Newly Arrived Refugees in Denmark: A Cross-Sectional Study of Prevalence and Clinical Management in Primary Care"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4073-7595","authenticated-orcid":false,"given":"Kamilla","family":"Lanng","sequence":"first","affiliation":[{"name":"Center for Global Health (GloHAU), Department of Public Health, Aarhus University, 8000 Aarhus C, Denmark"},{"name":"Department of Internal Medicine, Viborg Regional Hospital, 8800 Viborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2388-469X","authenticated-orcid":false,"given":"Rebecca Vigh","family":"Margolinsky","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Aarhus University Hospital, 8200 Aarhus N, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, 8200 Aarhus N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2534-2942","authenticated-orcid":false,"given":"Christian","family":"Wejse","sequence":"additional","affiliation":[{"name":"Center for Global Health (GloHAU), Department of Public Health, Aarhus University, 8000 Aarhus C, Denmark"},{"name":"Department of Infectious Diseases, Aarhus University Hospital, 8200 Aarhus N, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, 8200 Aarhus N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-4510","authenticated-orcid":false,"given":"Per","family":"Kallestrup","sequence":"additional","affiliation":[{"name":"Center for Global Health (GloHAU), Department of Public Health, Aarhus University, 8000 Aarhus C, Denmark"},{"name":"Research Unit for General Practice, Aarhus University, 8000 Aarhus C, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Mette Fl\u00f8e","family":"Hvass","sequence":"additional","affiliation":[{"name":"Center for Global Health (GloHAU), Department of Public Health, Aarhus University, 8000 Aarhus C, Denmark"},{"name":"Department of Public Health Programs, Randers Regional Hospital, Central Denmark Region, 8930 Randers N\u00d8, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"ref_1","unstructured":"(2025, January 23). Medecins Sans Fronti\u00e8res: Obstacle Course to Europe (MSF Report 2016). Available online: https:\/\/www.msf.org\/sites\/default\/files\/msf_obstacle_course_to_europe_0.pdf."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Pavli, A., and Maltezou, H. (2017). Health problems of newly arrived migrants and refugees in Europe. J. Travel Med., 24.","DOI":"10.1093\/jtm\/tax016"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1093\/cid\/cis1015","article-title":"Spectrum of illness in international migrants seen at GeoSentinel clinics in 1997\u20132009, part 1: US-bound migrants evaluated by comprehensive protocol-based health assessment","volume":"56","author":"Barnett","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Pavlopoulou, I.D., Tanaka, M., Dikalioti, S., Samoli, E., Nisianakis, P., Boleti, O.D., and Tsoumakas, K. (2017). Clinical and laboratory evaluation of new immigrant and refugee children arriving in Greece. BMC Pediatr., 17.","DOI":"10.1186\/s12887-017-0888-7"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Belhassen-Garc\u00eda, M., Pardo-Lled\u00edas, J., P\u00e9rez Del Villar, L., Muro, A., Velasco-Tirado, V., Bl\u00e1zquez de Castro, A., Vicente, B., Garc\u00eda Garc\u00eda, M.I., Luis Mu\u00f1oz Bellido, J., and Cordero-S\u00e1nchez, M. (2014). Relevance of eosinophilia and hyper-IgE in immigrant children. Medicine, 93.","DOI":"10.1097\/MD.0000000000000043"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.3201\/eid1210.060102","article-title":"Helminth-related Eosinophilia in African immigrants, Gran Canaria","volume":"12","author":"Pardo","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.tmaid.2017.09.001","article-title":"Helminthic infections in returning travelers and migrants with eosinophilia: Diagnostic value of medical history, eosinophil count and IgE","volume":"20","author":"Salzer","year":"2017","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1053\/jinf.2002.1108","article-title":"Investigation of tropical eosinophilia; assessing a strategy based on geographical area","volume":"46","author":"Whetham","year":"2003","journal-title":"J. Infect."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"Colley","year":"2014","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Requena-M\u00e9ndez, A., Chiodini, P., Bisoffi, Z., Buonfrate, D., Gotuzzo, E., and Mu\u00f1oz, J. (2013). The laboratory diagnosis and follow up of strongyloidiasis: A systematic review. PLoS Negl. Trop. Dis., 7.","DOI":"10.1371\/journal.pntd.0002002"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Greaves, D., Coggle, S., Pollard, C., Aliyu, S.H., and Moore, E.M. (2013). Strongyloides stercoralis infection. BMJ, 347.","DOI":"10.1136\/bmj.f4610"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Hotez, P.J., Alvarado, M., Bas\u00e1\u00f1ez, M.G., Bolliger, I., Bourne, R., Boussinesq, M., Brooker, S.J., Brown, A.S., Buckle, G., and Budke, C.M. (2014). The global burden of disease study 2010: Interpretation and implications for the neglected tropical diseases. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0002865"},{"key":"ref_13","first-page":"201","article-title":"Failure to offer parasitology screening to vulnerable migrants in France: Epidemiology and consequences","volume":"20","author":"Deniaud","year":"2010","journal-title":"Sante"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Buonfrate, D., Requena-Mendez, A., Angheben, A., Mu\u00f1oz, J., Gobbi, F., Van Den Ende, J., and Bisoffi, Z. (2013). Severe strongyloidiasis: A systematic review of case reports. BMC Infect. Dis., 13.","DOI":"10.1186\/1471-2334-13-78"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/eurpub\/cku123","article-title":"How do immigrants use primary health care services? A register-based study in Norway","volume":"25","author":"Diaz","year":"2015","journal-title":"Eur. J. Public Health"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1136\/pgmj.2004.026237","article-title":"Access to health care for ethnic minority populations","volume":"81","author":"Szczepura","year":"2005","journal-title":"Postgrad. Med. J."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Hvass, A.M.F., Nyboe, L., Lanng, K., Nielsen, C.V., and Wejse, C. (2022). A Mental Health Profile of 900 Newly Arrived Refugees in Denmark Using ICD-10 Diagnoses. Sustainability, 14.","DOI":"10.3390\/su14010418"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Brandenberger, J., Tyllesk\u00e4r, T., Sontag, K., Peterhans, B., and Ritz, N. (2019). A systematic literature review of reported challenges in health care delivery to migrants and refugees in high-income countries\u2014The 3C model. BMC Public Health, 19.","DOI":"10.1186\/s12889-019-7049-x"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1177\/14034948231158847","article-title":"Is being a refugee associated with increased 30-day mortality after visiting the emergency department? A register-based cohort study using Danish data","volume":"52","author":"Storgaard","year":"2023","journal-title":"Scand. J. Public Health"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hvass, A.M.F., Norredam, M., Sodemann, M., and Wejse, C. (2021). Is there a need of health assessments for resettling refugees? A cross-sectional study of 1431 refugees who arrived in Denmark between 2014 and 2018. J. Migr. Health, 3.","DOI":"10.1016\/j.jmh.2021.100044"},{"key":"ref_21","unstructured":"Bjerrum, O.W., Fassi, D.E., Madsen, G., Stentoft, J., Vestergaard, H., R\u00f8nnov-Jessen, D., Pedersen, P.T., Pulczynski, S., Overgaard, U.M., and Andersen, C.L. (2018). Eosinophilia. Ugeskr. Laeger, 180."},{"key":"ref_22","unstructured":"United Nations Statistics Division (2025, January 23). Standard Country or Area Codes for Statistical Use (M49). Available online: https:\/\/unstats.un.org\/unsd\/methodology\/m49\/."},{"key":"ref_23","unstructured":"(2025, January 23). Eurostat: Asylum Statistics 2019. Available online: https:\/\/ec.europa.eu\/eurostat\/cache\/infographs\/asylum\/asylum_2019\/."},{"key":"ref_24","unstructured":"Danish Ministry of Immigration and Integration: International Migration\u2014Denmark (2025, January 23). Report to OECD (2019). Available online: https:\/\/uim.dk\/publikationer\/2019\/international-migration-denmark-2019\/."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jinf.2017.08.007","article-title":"The changing aetiology of eosinophilia in migrants and returning travellers in the Hospital for Tropical Diseases, London 2002\u20132015: An observational study","volume":"75","author":"Barrett","year":"2017","journal-title":"J. Infect."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1053\/j.seminhematol.2012.01.006","article-title":"Evaluation and differential diagnosis of marked, persistent eosinophilia","volume":"49","author":"Mejia","year":"2012","journal-title":"Semin. Hematol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1179\/000349802125002374","article-title":"Lymphatic filariasis elimination: Progress in global programme development","volume":"96","author":"Molyneux","year":"2002","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s40249-016-0147-4","article-title":"The health and economic benefits of the global programme to eliminate lymphatic filariasis (2000\u20132014)","volume":"5","author":"Turner","year":"2016","journal-title":"Infect. Dis. Poverty"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/01.qco.0000247591.13671.6a","article-title":"Schistosomiasis: Challenges for control, treatment and drug resistance","volume":"19","author":"Fenwick","year":"2006","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.pcl.2017.03.005","article-title":"The Global State of Helminth Control and Elimination in Children","volume":"64","author":"Weatherhead","year":"2017","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Pion, S.D.S., Chesnais, C.B., Awaca-Uvon, N.P., Vlaminck, J., Abdou, A., Kunyu-Shako, B., Kuyangisa Simuna, G., Tambwe, J.P., Weil, G.J., and Boussinesq, M. (2020). The impact of four years of semiannual treatments with albendazole alone on lymphatic filariasis and soil-transmitted helminth infections: A community-based study in the Democratic Republic of the Congo. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008322"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Mduluza, T., Jones, C., Osakunor, D.N.M., Lim, R., Kuebel, J.K., Phiri, I., Manangazira, P., Tagwireyi, P., and Mutapi, F. (2020). Six rounds of annual praziquantel treatment during a national helminth control program significantly reduced schistosome infection and morbidity levels in a cohort of schoolchildren in Zimbabwe. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008388"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Janda, A., Eder, K., Fressle, R., Geweniger, A., Diffloth, N., Heeg, M., Binder, N., Sitaru, A.G., Rohr, J., and Henneke, P. (2020). Comprehensive infectious disease screening in a cohort of unaccompanied refugee minors in Germany from 2016 to 2017: A cross-sectional study. PLoS Med., 17.","DOI":"10.1371\/journal.pmed.1003076"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/clinids\/17.3.353","article-title":"Screening for schistosomiasis, filariasis, and strongyloidiasis among expatriates returning from the tropics","volume":"17","author":"Libman","year":"1993","journal-title":"Clin. Infect. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/03014460.2017.1330897","article-title":"Systematic health screening of refugees after resettlement in recipient countries: A scoping review","volume":"44","author":"Hvass","year":"2017","journal-title":"Ann. Hum. Biol."},{"key":"ref_36","unstructured":"(2025, January 23). L\u00e6geh\u00e5ndbogen (Danish Physician\u2019s Handbook), Imported Parasitic Diseases. Available online: https:\/\/www.sundhed.dk\/sundhedsfaglig\/laegehaandbogen\/infektioner\/symptomer-og-tegn\/importerede-parasitaere-sygdomme\/."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1086\/499238","article-title":"Diagnostic evaluation of newly arrived asymptomatic refugees with eosinophilia","volume":"42","author":"Seybolt","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/j.1365-4632.2007.03407.x","article-title":"Are age-specific high serum IgE levels associated with worse symptomatology in children with atopic dermatitis?","volume":"46","author":"Hon","year":"2007","journal-title":"Int. J. Dermatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1016\/S1473-3099(16)30535-7","article-title":"A call to strengthen the global strategy against schistosomiasis and soil-transmitted helminthiasis: The time is now","volume":"17","author":"Lo","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.puhe.2017.07.011","article-title":"Screening for infectious diseases among asylum seekers newly arrived in Germany in 2015: A systematic single-centre analysis","volume":"153","author":"Kortas","year":"2017","journal-title":"Public Health"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1111\/j.1365-3156.2010.02629.x","article-title":"Population movement: A key factor in the epidemiology of neglected tropical diseases","volume":"15","author":"Nombela","year":"2010","journal-title":"Trop. Med. Int. Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s15010-018-1167-8","article-title":"Refugees and family-reunified immigrants have a high incidence of HIV diagnosis and late presentation compared with Danish born: A nationwide register-based cohort study","volume":"46","author":"Deen","year":"2018","journal-title":"Infection"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1111\/apa.15879","article-title":"Health screening among children newly granted asylum in Denmark","volume":"110","author":"Frederiksen","year":"2021","journal-title":"Acta Paediatr."},{"key":"ref_44","unstructured":"Andersen, M.H., Kruse, A., Frederiksen, H.W., Ahmadi, A., and Norredam, M. (2020). Health status of refugees newly resettled in Denmark. Dan. Med. J., 67."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/INF.0000000000003390","article-title":"Eosinophilia in Migrant Children: How Should We Proceed?","volume":"41","author":"Bustamante","year":"2022","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Bustamante, J., Sainz, T., Ara-Montojo, M.F., Almir\u00f3n, M.D., Subirats, M., Vega, D.M., Mellado, M.J., and L\u00f3pez-Hortelano, M.G. (2022). Screening for parasites in migrant children. Travel. Med. Infect. Dis., 47.","DOI":"10.1016\/j.tmaid.2022.102287"},{"key":"ref_47","unstructured":"(2025, January 23). European Centre for Disease Prevention and Control (ECDC): Public Health Guidance on Screening and Vaccination for Infectious Diseases in Newly Arrived Migrants Within the EU\/EEA. Available online: www.ecdc.europa.eu\/sites\/default\/files\/documents\/Public%20health%20guidance%20on%20screening%20and%20vaccination%20of%20migrants%20in%20the%20EU%20EEA.pdf."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/22\/2\/180\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:37:48Z","timestamp":1759919868000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/22\/2\/180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,28]]},"references-count":47,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["ijerph22020180"],"URL":"https:\/\/doi.org\/10.3390\/ijerph22020180","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,28]]}}}