{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:03:01Z","timestamp":1760058181394,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"Intramural Research Program of the National Center for Advancing Translational Sciences, National Institutes of Health","doi-asserted-by":"publisher","award":["1ZIATR000056-07","75F40121S35006"],"award-info":[{"award-number":["1ZIATR000056-07","75F40121S35006"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Office of the Secretary Patient-Centered Outcomes Research Trust Fund under Interagency Agreement","award":["1ZIATR000056-07","75F40121S35006"],"award-info":[{"award-number":["1ZIATR000056-07","75F40121S35006"]}]},{"name":"C-Path related to Office of Secretary Patient-Centered Outcomes Research Trust Funding","award":["1ZIATR000056-07","75F40121S35006"],"award-info":[{"award-number":["1ZIATR000056-07","75F40121S35006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Data-driven approaches to clinical research are necessary for understanding and effectively treating infectious diseases. However, challenges such as issues with data validity, lack of collaboration, and difficult-to-treat infectious diseases (e.g., those that are rare or newly emerging) hinder research. Prioritizing innovative methods to facilitate the continued use of data generated during routine clinical care for research, but in an organized, accelerated, and shared manner, is crucial. This study investigates the potential of CURE ID, an open-source platform to accelerate drug-repurposing research for difficult-to-treat diseases, with COVID-19 as a use case. Data from eight US health systems were analyzed using least absolute shrinkage and selection operator (LASSO) regression to identify key predictors of 28-day all-cause mortality in COVID-19 patients, including demographics, comorbidities, treatments, and laboratory measurements captured during the first two days of hospitalization. Key findings indicate that age, laboratory measures, severity of illness indicators, oxygen support administration, and comorbidities significantly influenced all-cause 28-day mortality, aligning with previous studies. This work underscores the value of collaborative repositories like CURE ID in providing robust datasets for prognostic research and the importance of factor selection in identifying key variables, helping to streamline future research and drug-repurposing efforts.<\/jats:p>","DOI":"10.3390\/ijerph22040464","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T07:25:00Z","timestamp":1742541900000},"page":"464","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wrangling Real-World Data: Optimizing Clinical Research Through Factor Selection with LASSO Regression"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0107-5202","authenticated-orcid":false,"given":"Kerry A.","family":"Howard","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences, Clemson University, Clemson, SC 29634, USA"},{"name":"Center for Public Health Modeling and Response, Clemson University, Clemson, SC 29634, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wes","family":"Anderson","sequence":"additional","affiliation":[{"name":"Critical Path Institute, Tucson, AZ 85718, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3922-3549","authenticated-orcid":false,"given":"Jagdeep T.","family":"Podichetty","sequence":"additional","affiliation":[{"name":"Critical Path Institute, Tucson, AZ 85718, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Gould","sequence":"additional","affiliation":[{"name":"Centers of Disease Control and Prevention, Atlanta, GA 30329, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Boyce","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine, Tufts University, Medford, MA 02155, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pam","family":"Dasher","sequence":"additional","affiliation":[{"name":"Critical Path Institute, Tucson, AZ 85718, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Evans","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA 98195, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Kao","sequence":"additional","affiliation":[{"name":"IR Research & Academic Systems, University of Texas Southwestern, Dallas, TX 75390, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishakha K.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Society of Critical Care Medicine, Mount Prospect, IL 60056, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chase","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Society of Critical Care Medicine, Mount Prospect, IL 60056, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4491-8107","authenticated-orcid":false,"given":"Ewy","family":"Math\u00e9","sequence":"additional","affiliation":[{"name":"National Institutes of Health National Center for Advancing Translational Sciences (NCATS), Rockville, MD 20850, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe J.","family":"Guerin","sequence":"additional","affiliation":[{"name":"Infectious Diseases Data Observatory (IDDO), Nuffield Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 LF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Dodd","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Advocate Christ Medical Center, Oak Lawn, IL 60453, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneesh K.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Emory University, Atlanta, GA 30322, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0934-1157","authenticated-orcid":false,"given":"Chris","family":"Ortman","sequence":"additional","affiliation":[{"name":"Institute for Translational and Clinical Science, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namrata","family":"Patil","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5776-2386","authenticated-orcid":false,"given":"Jeselyn","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Emory University, Atlanta, GA 30322, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Johns Hopkins University, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4601-5975","authenticated-orcid":false,"given":"Heather","family":"Stone","sequence":"additional","affiliation":[{"name":"US Food and Drug Administration, Silver Spring, MD 20993, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0912-0407","authenticated-orcid":false,"given":"Smith F.","family":"Heavner","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Clemson University, Clemson, SC 29634, USA"},{"name":"Critical Path Institute, Tucson, AZ 85718, USA"},{"name":"Department of Biomedical Sciences, University of South Carolina School of Medicine Greenville, Greenville, SC 29605, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1001\/jama.2017.15033","article-title":"The Critical Role of Biomedical Research in Pandemic Preparedness","volume":"318","author":"Marston","year":"2017","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1056\/NEJMp1806283","article-title":"Innovation for Pandemics","volume":"378","author":"Gates","year":"2018","journal-title":"N. 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