{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:04:56Z","timestamp":1760058296519,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Debrecen Program for Scientific Publication"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>We aimed to determine the effects of night-shift work on corneal parameters in thirty-five healthy individuals (24\u201359 years) in a retrospective cohort study. Among them, 12 hospital nurses regularly worked two shifts, spending a third of their nights awake, whereas 23 age-matched controls never worked shifts and slept regularly. Measurements were performed at least five times within 12 h. We analyzed the keratometric parameters of the corneal front (F) and back (B) surfaces, including the refractive power in the flattest and steepest axes (K1, K2), astigmatism (Astig); and corneal pachymetry (Pachy) at the thinnest corneal point and pupil center, volume relative to the 10 mm corneal diagonal (Vol D10); and surface variance index (ISV). A multilevel mixed-effects linear regression adjusted for age was applied to 905 measurements. All parameters exhibited significant periodic fluctuations (p \u2264 0.005). The two groups also showed significantly different periodic fluctuations (p \u2264 0.008), except in K1B and AstigB. K1\/K2 (F and B), AstigF, Pachy, and ISV differed significantly (p &lt; 0.0001). Surprisingly, prolonged night shift work did not increase the ISV, and no evidence of age-related corneal thinning was observed. Long-term night-shift exposures change various corneal parameters, reflecting both concomitant and adaptive effects. This study highlights the impact of consistent sleep deprivation on corneal properties, warranting further research into understanding the long-term effects of night-shift work.<\/jats:p>","DOI":"10.3390\/ijerph22040474","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T13:48:20Z","timestamp":1742824100000},"page":"474","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Decades of Night-Shift Work Induce Diurnal Disruption and Corneal Adaptations: Evidence from Pentacam Analysis"],"prefix":"10.3390","volume":"22","author":[{"given":"Bence Lajos","family":"Kolozsv\u00e1ri","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Gyula Petr\u00e1nyi Doctoral School of Allergy and Clinical Immunology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7951-6004","authenticated-orcid":false,"given":"\u00c9va","family":"Sur\u00e1nyi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Gyula Petr\u00e1nyi Doctoral School of Allergy and Clinical Immunology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8444-6725","authenticated-orcid":false,"given":"Zsuzsa Zakarn\u00e9","family":"Aszal\u00f3s","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Gyula Petr\u00e1nyi Doctoral School of Allergy and Clinical Immunology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivien","family":"L\u00e9n\u00e1rt","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Gyula Petr\u00e1nyi Doctoral School of Allergy and Clinical Immunology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0800-1082","authenticated-orcid":false,"given":"Reda","family":"Chaker","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Gyula Petr\u00e1nyi Doctoral School of Allergy and Clinical Immunology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9139-3572","authenticated-orcid":false,"given":"G\u00e9za","family":"Vit\u00e1lyos","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry and Orthodontics, Faculty of Dentistry, University of Debrecen, 4012 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariann","family":"Fodor","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Gyula Petr\u00e1nyi Doctoral School of Allergy and Clinical Immunology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4856","DOI":"10.1167\/iovs.18-24957","article-title":"Ocular clocks: Adapting mechanisms for eye functions and health","volume":"59","author":"Buhr","year":"2018","journal-title":"Investing. 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