{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:35:07Z","timestamp":1778636107046,"version":"3.51.4"},"reference-count":57,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Connors Center Award","award":["31081"],"award-info":[{"award-number":["31081"]}]},{"name":"Connors Center Award","award":["K23MH129829"],"award-info":[{"award-number":["K23MH129829"]}]},{"name":"Connors Center Award","award":["R01MH113929"],"award-info":[{"award-number":["R01MH113929"]}]},{"name":"Brain and Behavior Research Foundation Young Investigator Grant","award":["31081"],"award-info":[{"award-number":["31081"]}]},{"name":"Brain and Behavior Research Foundation Young Investigator Grant","award":["K23MH129829"],"award-info":[{"award-number":["K23MH129829"]}]},{"name":"Brain and Behavior Research Foundation Young Investigator Grant","award":["R01MH113929"],"award-info":[{"award-number":["R01MH113929"]}]},{"name":"Mass General Brigham Accelerator Grant","award":["31081"],"award-info":[{"award-number":["31081"]}]},{"name":"Mass General Brigham Accelerator Grant","award":["K23MH129829"],"award-info":[{"award-number":["K23MH129829"]}]},{"name":"Mass General Brigham Accelerator Grant","award":["R01MH113929"],"award-info":[{"award-number":["R01MH113929"]}]},{"name":"Mass General Brigham Women\u2019s Brain Initiative Grant","award":["31081"],"award-info":[{"award-number":["31081"]}]},{"name":"Mass General Brigham Women\u2019s Brain Initiative Grant","award":["K23MH129829"],"award-info":[{"award-number":["K23MH129829"]}]},{"name":"Mass General Brigham Women\u2019s Brain Initiative Grant","award":["R01MH113929"],"award-info":[{"award-number":["R01MH113929"]}]},{"name":"NIH","award":["31081"],"award-info":[{"award-number":["31081"]}]},{"name":"NIH","award":["K23MH129829"],"award-info":[{"award-number":["K23MH129829"]}]},{"name":"NIH","award":["R01MH113929"],"award-info":[{"award-number":["R01MH113929"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Perinatal depression affects approximately 1 in 5 women and is the leading cause of maternal mortality in the United States. In addition to evidence-based treatment with antidepressant medications, there has been a push to identify rapid-acting options for pregnant and postpartum individuals. This paper reviews the evidence behind new pharmacological agents (neurosteroids and ketamine) and non-pharmacological approaches (transcranial magnetic stimulation). The paper also highlights the risks and benefits of electroconvulsive therapy and selective serotonin reuptake inhibitors. Based on recent studies and research, the paper provides considerations when prescribing these modalities including: timing of symptom onset, severity of presentation, breastfeeding priorities, prior treatment response and treatment availability and cost.<\/jats:p>","DOI":"10.3390\/ijerph22040546","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T07:47:44Z","timestamp":1743580064000},"page":"546","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rapid-Acting Treatments for Perinatal Depression: Clinical Landscapes and Future Horizons"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6703-9132","authenticated-orcid":false,"given":"Emily M.","family":"Beydler","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA"},{"name":"Penn Center for Women\u2019s Behavioral Wellness, University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8320-1910","authenticated-orcid":false,"given":"Amanda","family":"Koire","sequence":"additional","affiliation":[{"name":"AMC Department of Psychiatry, Mass General Brigham, Boston, MA 02115, USA"},{"name":"Mary Horrigan Connors Center for Women\u2019s Health and Gender Biology, Brigham and Women\u2019s Hospital, Boston, MA 02115, USA"},{"name":"Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Steuber","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA 02115, USA"},{"name":"Department of Psychiatry, Boston Children\u2019s Hospital, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9185-0427","authenticated-orcid":false,"given":"Joseph J.","family":"Taylor","sequence":"additional","affiliation":[{"name":"AMC Department of Psychiatry, Mass General Brigham, Boston, MA 02115, USA"},{"name":"Harvard Medical School, Boston, MA 02115, USA"},{"name":"Center for Brain Circuit Therapeutics, Mass General Brigham, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-649X","authenticated-orcid":false,"given":"Reid J.","family":"Mergler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA"},{"name":"Penn Center for Women\u2019s Behavioral Wellness, University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"ref_1","first-page":"273","article-title":"Perinatal depression: A review","volume":"87","author":"Payne","year":"2020","journal-title":"Clevel. 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