{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:03:20Z","timestamp":1793243000669,"version":"4.5.0"},"reference-count":175,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"RAK College of Dental Sciences","award":["5"],"award-info":[{"award-number":["5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Periodontal disease is a prevalent chronic inflammatory condition that impacts over a billion people worldwide, leading to substantial tooth loss, reduced quality of life, and heightened systemic health risks. This narrative review synthesizes current evidence regarding the global burden of periodontal disease, its established associations with systemic conditions including cardiovascular disease, diabetes, adverse pregnancy outcomes, respiratory infections, and neurodegenerative disorders, and its significant socioeconomic implications. The review focused on the following research question: What is the global burden of periodontal disease, and how do its systemic and socioeconomic implications necessitate integrated public health strategies? A structured search of the PubMed, Scopus, and WHO databases from 2000 to 2024 was conducted to identify relevant literature using key terms, including \u201cperiodontal disease\u201d, \u201cglobal burden\u201d, \u201csystemic inflammation\u201d, and \u201cpublic health strategies\u201d. Out of 312 initially identified articles, 175 satisfied the inclusion criteria for the final synthesis. The findings underscore the significance of periodontal disease as a modifiable risk factor for various noncommunicable diseases, the influence of healthcare disparities on disease progression, and the critical necessity for integrated public health strategies to mitigate the global burden of periodontal disease and its consequences. The review concludes that coordinated policy reform, health system integration, and enhanced research efforts are crucial for mitigating the global burden of periodontal disease and advancing health equity.<\/jats:p>","DOI":"10.3390\/ijerph22040624","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T08:09:17Z","timestamp":1744790957000},"page":"624","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":125,"title":["The Global Burden of Periodontal Disease: A Narrative Review on Unveiling Socioeconomic and Health Challenges"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5485-2768","authenticated-orcid":false,"given":"Nada Tawfig","family":"Hashim","sequence":"first","affiliation":[{"name":"Department of Periodontics, RAK College of Dental Sciences, RAK Medical & Health Sciences University, Ras-AlKhaimah 12973, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9456-2033","authenticated-orcid":false,"given":"Rasha","family":"Babiker","sequence":"additional","affiliation":[{"name":"Department of Physiology, RAK College of Medical Sciences, RAK Medical & Health Sciences University, Ras-AlKhaimah 11127, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, RAK College of Dental Sciences, RAK Medical & Health Sciences University, Ras-AlKhaimah 12973, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-8638","authenticated-orcid":false,"given":"Azza Tagelsir","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, University of Illinois Chicago, Chicago, IL 60607, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nallan C. S. K.","family":"Chaitanya","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, RAK College of Dental Sciences, RAK Medical & Health Sciences University, Ras-AlKhaimah 12973, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3017-6245","authenticated-orcid":false,"given":"Riham","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department Oral Surgery, RAK College of Dental Sciences, RAK Medical & Health Sciences University, Ras-AlKhaimah 12973, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3162-5834","authenticated-orcid":false,"given":"Sivan Padma","family":"Priya","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, RAK College of Dental Sciences, RAK Medical & Health Sciences University, Ras-AlKhaimah 12973, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Nile University, Khartoum 11115, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7302-7261","authenticated-orcid":false,"given":"Shadi","family":"El Bahra","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, RAK College of Dental Sciences, RAK Medical & Health Sciences University, Ras-AlKhaimah 12973, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0604-9553","authenticated-orcid":false,"given":"Md Sofiqul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry, RAK College of Dental Sciences, RAK Medical & Health Sciences University, Ras-AlKhaimah 12973, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bakri Gobara","family":"Gismalla","sequence":"additional","affiliation":[{"name":"Department of Oral Rehabilitation, Faculty of Dentistry, University of Khartoum, Khartoum 11115, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Mustahsen","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Periodontics, RAK College of Dental Sciences, RAK Medical & Health Sciences University, Ras-AlKhaimah 12973, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal Diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat. 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